Genome-wide Association Study for Radiographic Vertebral Fractures: A Potential Role for the 16q24 BMD Locus versus Lessons Learned from Challenging Phenotype Definition (Q57315738)

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English	Genome-wide Association Study for Radiographic Vertebral Fractures: A Potential Role for the 16q24 BMD Locus versus Lessons Learned from Challenging Phenotype Definition	No description defined

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scholarly article

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Genome-wide Association Study for Radiographic Vertebral Fractures: A Potential Role for the 16q24 BMD Locus versus Lessons Learned from Challenging Phenotype Definition (English)

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genome-wide association study

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lessons learned

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based on heuristic

inferred from title

Magnus K Karlsson

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Magnus K Karlsson

35

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Unnur Styrkarsdottir

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Unnur Styrkarsdottir

46

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Carolina Medina-Gomez

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Carolina Medina-Gómez

24

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Liesbeth Vandenput

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Liesbeth Vandenput

25

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Emma L Duncan

3

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Evangelos Evangelou

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Evangelos Evangelou

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David Karasik

44

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Jose Luis Hernandez

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Jose L Hernandez

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Matthew A. Brown

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Matthew A Brown

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David M Evans

15

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Douglas P. Kiel

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Douglas P Kiel

53

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Fernando Rivadeneira

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Fernando Rivadeneira

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Jonathan Reeve

50

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41

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John P A Ioannidis

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Claes Ohlsson

51

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33

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Dan Mellström

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36

object named as

Albert Hofman

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Eugene V McCloskey

11

object named as

Eugene McCloskey

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Natasja M van Schoor

10

object named as

Natasja M van Schoor

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André Uitterlinden

45

object named as

André G Uitterlinden

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Joyce B J van Meurs

40

object named as

Joyce B J van Meurs

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43

object named as

Paul Lips

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L. Adrienne Cupples

23

object named as

L Adrienne Cupples

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M. Carola Zillikens

42

object named as

M Carola Zillikens

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1

object named as

Ling Oei

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Stuart H Ralston

52

object named as

Stuart H Ralston

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José A Riancho

8

object named as

José A Riancho

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2

object named as

Karol Estrada

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Claus B Christiansen

4

object named as

Claus Christiansen

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Bente L Langdahl

6

object named as

Bente L Langdahl

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Stephen K Kaptoge

21

object named as

Stephen K Kaptoge

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Evangelia Ntzani

14

object named as

Evangelia Ntzani

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26

object named as

Ghi Su Kim

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48

object named as

Jung-Min Koh

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Barbara Obermayer-Pietsch

7

object named as

Barbara Obermayer-Pietsch

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38

object named as

Huibert A P Pols

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39

object named as

Lisette Stolk

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Lise Bjerre Husted

17

object named as

Lise B Husted

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Martha Cecilia Castano-Betancourt

28

object named as

Martha C Castaño-Betancourt

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29

object named as

Edwin H G Oei

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Anna Daroszewska

31

object named as

Anna Daroszewska

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Marjolein van der Klift

32

object named as

Marjolein van der Klift

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author name string

Ching-Ti Liu

5

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Richard L Prince

9

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Yi-Hsiang Hsu

12

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Nerea Alonso

16

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Carmen Valero

18

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Joshua R Lewis

20

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Kun Zhu

22

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Seung Hun Lee

27

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Josefina Martinez

30

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Lizbeth Herrera

34

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Osten Ljunggren

37

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J Brent Richards

49

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language of work or name

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publication date

25 October 2013

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describes a project that uses

genome-wide association study

1 reference

based on heuristic

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Genetic analyses in a sample of individuals with high or low BMD shows association with multiple Wnt pathway genes

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Bone turnover markers in Spanish adult men The Camargo Cohort Study.

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Incidence and economic burden of osteoporosis-related fractures in the United States, 2005-2025.

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The incidence of vertebral fractures in men and women: the Rotterdam Study

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A statistical method to minimize magnification errors in serial vertebral radiographs.

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Clinical consequences of vertebral fractures

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The Third Generation Cohort of the National Heart, Lung, and Blood Institute's Framingham Heart Study: Design, Recruitment, and Initial Examination

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Principal components analysis corrects for stratification in genome-wide association studies

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The clinical impact of vertebral fractures: quality of life in women with osteoporosis

1 reference

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Free testosterone is an independent predictor of BMD and prevalent fractures in elderly men: MrOS Sweden

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Adiposity, estradiol, and genetic variants of steroid-metabolizing enzymes as determinants of bone mineral density

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Attrition in the Longitudinal Aging Study Amsterdam. The effect of differential inclusion in side studies.

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Defining Incident Vertebral Deformities in Population Studies: A Comparison of Morphometric Criteria

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Genome-wide association study identifies novel breast cancer susceptibility loci

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A family history of fracture and fracture risk: a meta-analysis.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

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Vertebral compression fractures in primary care: recommendations from a consensus panel.

1 reference

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Large-scale evidence for the effect of the COLIA1 Sp1 polymorphism on osteoporosis outcomes: the GENOMOS study

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https://pubmed.ncbi.nlm.nih.gov/24516880

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Severity of vertebral fracture and risk of hip fracture: a nested case-control study

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Prevalent vertebral deformities predict hip fractures and new vertebral deformities but not wrist fractures. Study of Osteoporotic Fractures Research Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

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Correcting "winner's curse" in odds ratios from genomewide association findings for major complex human diseases.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

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based on heuristic

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Large-scale analysis of association between polymorphisms in the transforming growth factor beta 1 gene (TGFB1) and osteoporosis: the GENOMOS study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

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Recommendations for standardization and phenotype definitions in genetic studies of osteoarthritis: the TREAT-OA consortium

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

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Validity of Self-Report of Fractures: Results from a Prospective Study in Men and Women Across Europe

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

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Estimation of the prevalence of low bone density in Canadian women and men using a population-specific DXA reference standard: the Canadian Multicentre Osteoporosis Study (CaMos).

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

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Genotype imputation

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

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Prevalence of Osteoporosis in Australian Women

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https://pubmed.ncbi.nlm.nih.gov/24516880

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based on heuristic

inferred from PubMed ID database lookup

Genetics of osteoporosis from genome-wide association studies: advances and challenges

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

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What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations

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Random-effects model aimed at discovering associations in meta-analysis of genome-wide association studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

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The assessment of vertebral deformity: a method for use in population studies and clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

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Prevalent vertebral deformities predict mortality and hospitalization in older women with low bone mass. Fracture Intervention Trial Research Group.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

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Generalizability and epidemiologic characterization of eleven colorectal cancer GWAS hits in multiple populations

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12 December 2020

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Incidence and Risk Factors for Vertebral Fracture in Women and Men: 25-Year Follow-Up Results From the Population-Based Framingham Study

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Mortality risk associated with low-trauma osteoporotic fracture and subsequent fracture in men and women.

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The Rotterdam Study: 2012 objectives and design update

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Clodronate reduces the incidence of fractures in community-dwelling elderly women unselected for osteoporosis: results of a double-blind, placebo-controlled randomized study

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METAL: fast and efficient meta-analysis of genomewide association scans

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An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population

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Identification of an aromatase haplotype that is associated with gene expression and postmenopausal osteoporosis

1 reference

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12 December 2020

based on heuristic

inferred from PubMed ID database lookup

An investigation of coronary heart disease in families. The Framingham offspring study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

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Changes to osteoporosis prevalence according to method of risk assessment.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

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Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Integrating common and rare genetic variation in diverse human populations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

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Genomewide association studies and assessment of the risk of disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

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GRIMP: a web- and grid-based tool for high-speed analysis of large-scale genome-wide association using imputed data

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of calcium supplementation on clinical fracture and bone structure: results of a 5-year, double-blind, placebo-controlled trial in elderly women.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Association of FLT3 polymorphisms with low BMD and risk of osteoporotic fracture in postmenopausal women

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The winged helix transcription factor MFH1 is required for proliferation and patterning of paraxial mesoderm in the mouse embryo

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Heritability of prevalent vertebral fracture and volumetric bone mineral density and geometry at the lumbar spine in three generations of the Framingham study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vertebral fractures predict subsequent fractures

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genotypes and haplotypes of the estrogen receptor genes, but not the retinoblastoma-interacting zinc finger protein 1 gene, are associated with osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

MaCH: using sequence and genotype data to estimate haplotypes and unobserved genotypes

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The forkhead transcription factor Foxc2 stimulates osteoblast differentiation.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Determinants of the size of incident vertebral deformities in European men and women in the sixth to ninth decades of age: the European Prospective Osteoporosis Study (EPOS).

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Links between cardiovascular disease and osteoporosis in postmenopausal women: serum lipids or atherosclerosis per se?

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Comparison of methods for the visual identification of prevalent vertebral fracture in osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vertebral fracture assessment using a semiquantitative technique.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effect of selective serotonin reuptake inhibitors on the risk of fracture

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Review of radiological scoring methods of osteoporotic vertebral fractures for clinical and research settings

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Replication in Genome-Wide Association Studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The association of radiographically detected vertebral fractures with back pain and function: a prospective study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Type 2 diabetes mellitus in nursing home patients: effects on bone turnover, bone mass, and fracture risk

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Ranking of genome-wide association scan signals by different measures

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genetics of osteoporosis

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Incidence of vertebral fracture in europe: results from the European Prospective Osteoporosis Study (EPOS).

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Health-related quality of life in postmenopausal women with low BMD with or without prevalent vertebral fractures.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impact of incident vertebral fractures on health related quality of life (HRQOL) in postmenopausal women with prevalent vertebral fractures

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The Danish Osteoporosis Prevention Study (DOPS): project design and inclusion of 2000 normal perimenopausal women

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Vertebral deformities and functional impairment in men and women

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone mineral density reference ranges for Australian men: Geelong Osteoporosis Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The International HapMap Project

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Genomic and genic deletions of the FOX gene cluster on 16q24.1 and inactivating mutations of FOXF1 cause alveolar capillary dysplasia and other malformations

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone turnover markers in Spanish postmenopausal women: the Camargo cohort study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Epidemiological approaches to heart disease: the Framingham Study

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The prevalence of vertebral deformity in european men and women: the European Vertebral Osteoporosis Study.

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Osteoporosis: burden, health care provision and opportunities in the EU: a report prepared in collaboration with the International Osteoporosis Foundation (IOF) and the European Federation of Pharmaceutical Industry Associations (EFPIA).

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Why Most Discovered True Associations Are Inflated

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Bone morphogenetic protein regulation of forkhead/winged helix transcription factor Foxc2 (Mfh1) in a murine mesodermal cell line C1 and in skeletal precursor cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/24516880

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1016/J.BONE.2013.10.015

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