Lack of gp130 expression in hepatocytes promotes liver injury1 1K.L.S. and T.W. contributed equally to this work (Q57339931)

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6 November 2019

title

Lack of gp130 expression in hepatocytes promotes liver injury (English)

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6 November 2019

9

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6 November 2019

author name string

Torsten Wüstefeld

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6 November 2019

Christian Klein

3

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6 November 2019

Karl-Josef Kallen

4

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6 November 2019

Francois Tronche

5

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6 November 2019

Günther Schütz

7

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6 November 2019

Michael P Manns

8

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6 November 2019

Christian Trautwein

10

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Konrad L Streetz

1

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Ullrich A K Betz

6

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6 November 2019

language of work or name

English

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publication date

1 August 2003

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6 November 2019

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6 November 2019

volume

125

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issue

2

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page(s)

532-543

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Impaired immune and acute-phase responses in interleukin-6-deficient mice.

6 November 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Gp130 and the interleukin-6 family of cytokines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Targeted disruption of gp130, a common signal transducer for the interleukin 6 family of cytokines, leads to myocardial and hematological disorders

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

The signal transducer gp130 is shared by interleukin-6 family of haematopoietic and neurotrophic cytokines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Postnatally induced inactivation of gp130 in mice results in neurological, cardiac, hematopoietic, immunological, hepatic, and pulmonary defects

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Loss of a gp130 cardiac muscle cell survival pathway is a critical event in the onset of heart failure during biomechanical stress

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Fetal liver development requires a paracrine action of oncostatin M through the gp130 signal transducer

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

p18(INK4c) collaborates with other CDK-inhibitory proteins in the regenerating liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Concanavalin A-induced liver injury triggers hepatocyte proliferation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

The designer cytokine hyper-interleukin-6 is a potent activator of STAT3-dependent gene transcription in vivo and in vitro.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Hepatocyte-specific expression of Cre recombinase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

LPS and TNFalpha induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

The involvement of PI 3-K/Akt-dependent up-regulation of Mcl-1 in the prevention of apoptosis of Hep3B cells by interleukin-6.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Extent of the acute phase response in fulminant hepatic failure

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Enhanced expression of interleukin-6 in chronic hepatitis C

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Interleukin-6: an early marker of bacterial infection in decompensated cirrhosis

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Lipopolysaccharide and D-galactosamine-induced hepatic injury is mediated by TNF-alpha and not by Fas ligand

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Hepatocyte-derived interleukin-6 and tumor-necrosis factor alpha mediate the lipopolysaccharide-induced acute-phase response and nitric oxide release by cultured rat hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

TRADD-TRAF2 and TRADD-FADD interactions define two distinct TNF receptor 1 signal transduction pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

An essential role for NF-kappaB in preventing TNF-alpha-induced cell death

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Liver failure and defective hepatocyte regeneration in interleukin-6-deficient mice.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Retroviral gene transfer of signaling molecules into murine fetal hepatocytes defines distinct roles for the STAT3 and ras pathways during hepatic development

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Essential role of STAT3 in the control of the acute-phase response as revealed by inducible gene inactivation [correction of activation] in the liver

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Suppressor of cytokine signaling-3 is a biomechanical stress-inducible gene that suppresses gp130-mediated cardiac myocyte hypertrophy and survival pathways

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Interleukin-6 protects against Fas-mediated death by establishing a critical level of anti-apoptotic hepatic proteins FLIP, Bcl-2, and Bcl-xL.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Constitutive activation of Stat3 signaling confers resistance to apoptosis in human U266 myeloma cells

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Hepatocyte-specific inhibition of NF-kappaB leads to apoptosis after TNF treatment, but not after partial hepatectomy

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Interleukin-6-induced STAT3 and AP-1 amplify hepatocyte nuclear factor 1-mediated transactivation of hepatic genes, an adaptive response to liver injury

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Akt-dependent phosphorylation specifically regulates Cot induction of NF-kappa B-dependent transcription

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Granulocyte/macrophage-colony-stimulating factor (GM-CSF) regulates lung innate immunity to lipopolysaccharide through Akt/Erk activation of NFkappa B and AP-1 in vivo.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

IKK beta and phosphatidylinositol 3-kinase/Akt participate in non-pathogenic Gram-negative enteric bacteria-induced RelA phosphorylation and NF-kappa B activation in both primary and intestinal epithelial cell lines

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Sepsis and endotoxemia stimulate intestinal interleukin-6 production*

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Hyper-IL-6 gene therapy reverses fulminant hepatic failure.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

Protective effects of soyasapogenol A on liver injury mediated by immune response in a concanavalin A-induced hepatitis model

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0016-5085%2803%2900901-6

10.1016/S0016-5085(03)00901-6

7 January 2021

Identifiers

DOI

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6 November 2019

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