Synergy in tumor suppression by direct interaction of Neutral Endopeptidase with PTEN (Q57364534)

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17 November 2019

title

Synergy in tumor suppression by direct interaction of neutral endopeptidase with PTEN (English)

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17 November 2019

5

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17 November 2019

author name string

Makoto Sumitomo

1

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17 November 2019

Akira Iwase

2

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17 November 2019

Rong Zheng

3

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17 November 2019

Daniel Navarro

4

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17 November 2019

Ruoqian Shen

6

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17 November 2019

Maria-Magdalena Georgescu

7

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17 November 2019

David M Nanus

8

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17 November 2019

publication date

1 January 2004

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17 November 2019

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17 November 2019

volume

5

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17 November 2019

issue

1

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17 November 2019

page(s)

67-78

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New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway

17 November 2019

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Loss of CD10 (neutral endopeptidase) is a frequent and early event in human prostate cancer

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The tumor-suppressor activity of PTEN is regulated by its carboxyl-terminal region

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Protein kinase B (PKB/Akt) activity is elevated in glioblastoma cells due to mutation of the tumor suppressor PTEN/MMAC.

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Inhibition of protein kinase B/Akt. implications for cancer therapy

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Endopeptidase-24.11: putative substrates and possible roles

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Crystal structure of the PTEN tumor suppressor: implications for its phosphoinositide phosphatase activity and membrane association

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PTEN, a putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer

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The tumor suppressor, PTEN/MMAC1, dephosphorylates the lipid second messenger, phosphatidylinositol 3,4,5-trisphosphate

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PTEN and myotubularin: novel phosphoinositide phosphatases

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7 January 2021

Direct identification of PTEN phosphorylation sites

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7 January 2021

Small bioactive peptides and cell surface peptidases in androgen-independent prostate cancer

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Neutral endopeptidase 24.11 loss in metastatic human prostate cancer contributes to androgen-independent progression

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Caveolae/lipid rafts in fibroblast-like synoviocytes: ectopeptidase-rich membrane microdomains

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CD10/neutral endopeptidase 24.11 hydrolyzes bombesin-like peptides and regulates the growth of small cell carcinomas of the lung

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7 January 2021

Negative regulation of PKB/Akt-dependent cell survival by the tumor suppressor PTEN

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7 January 2021

Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers

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7 January 2021

Neutral endopeptidase inhibits prostate cancer cell migration by blocking focal adhesion kinase signaling

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7 January 2021

The tumor suppressor PTEN is phosphorylated by the protein kinase CK2 at its C terminus. Implications for PTEN stability to proteasome-mediated degradation

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7 January 2021

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7 January 2021

Phosphorylation of the PTEN tail regulates protein stability and function

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7 January 2021

Phosphorylation of the PTEN tail acts as an inhibitory switch by preventing its recruitment into a protein complex

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7 January 2021

Evidence for regulation of the PTEN tumor suppressor by a membrane-localized multi-PDZ domain containing scaffold protein MAGI-2

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7 January 2021

Interaction of the tumor suppressor PTEN/MMAC with a PDZ domain of MAGI3, a novel membrane-associated guanylate kinase

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Identifiers

DOI

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17 November 2019

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