EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A (Q57522263)

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29 January 2020

title

EWS/ETS proteins promote expression and regulate function of the homeodomain transcription factor BRN3A (English)

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29 January 2020

4

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author name string

D M Gascoyne

1

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29 January 2020

J Dunne

2

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29 January 2020

S Behjati

3

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29 January 2020

J Anderson

5

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29 January 2020

D S Latchman

6

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29 January 2020

language of work or name

English

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publication date

29 March 2010

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29 January 2020

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29 January 2020

volume

29

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issue

21

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29 January 2020

page(s)

3134-3145

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DNA-binding and transcriptional activation properties of the EWS-FLI-1 fusion protein resulting from the t(11;22) translocation in Ewing sarcoma

29 January 2020

cites work

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Interaction of Ets-1 and the POU-homeodomain protein GHF-1/Pit-1 reconstitutes pituitary-specific gene expression

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Gene expression of the POU factor Brn-3a is regulated by two different promoters

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The metastatic ability of Ewing's sarcoma cells is modulated by stem cell factor and by its receptor c-kit

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The Brn-3a transcription factor induces neuronal process outgrowth and the coordinate expression of genes encoding synaptic proteins

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Biology of EWS/ETS fusions in Ewing's family tumors

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Gene expression profiling of human sarcomas: insights into sarcoma biology

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GLI1 is a direct transcriptional target of EWS-FLI1 oncoprotein.

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A novel POU homeodomain gene specifically expressed in cells of the developing mammalian nervous system

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Analysis of the expression of cell cycle regulators in Ewing cell lines: EWS-FLI-1 modulates p57KIP2and c-Myc expression

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Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

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Alteration of mesodermal cell differentiation by EWS/FLI-1, the oncogene implicated in Ewing's sarcoma

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Defects in sensory axon growth precede neuronal death in Brn3a-deficient mice

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The BRN-3A transcription factor protects sensory but not sympathetic neurons from programmed cell death/apoptosis

31 March 2020

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Brn-3.0 expression identifies early post-mitotic CNS neurons and sensory neural precursors

31 March 2020

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Upregulation of Id2, an oncogenic helix-loop-helix protein, is mediated by the chimeric EWS/ets protein in Ewing sarcoma

31 March 2020

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The effects of Brn-3a on neuronal differentiation and apoptosis are differentially modulated by EWS and its oncogenic derivative EWS/Fli-1

31 March 2020

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Imatinib inhibits proliferation of Ewing tumor cells mediated by the stem cell factor/KIT receptor pathway, and sensitizes cells to vincristine and doxorubicin-induced apoptosis.

31 March 2020

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Repression of the gene encoding the TGF-beta type II receptor is a major target of the EWS-FLI1 oncoprotein

31 March 2020

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A developmental switch in the response of DRG neurons to ETS transcription factor signaling

31 March 2020

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Sequence-specific knockdown of EWS-FLI1 by targeted, nonviral delivery of small interfering RNA inhibits tumor growth in a murine model of metastatic Ewing's sarcoma

31 March 2020

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EWS-FLI1 fusion protein up-regulates critical genes in neural crest development and is responsible for the observed phenotype of Ewing's family of tumors

31 March 2020

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Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity

31 March 2020

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Cooperative DNA binding with AP-1 proteins is required for transformation by EWS-Ets fusion proteins

31 March 2020

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Brn3a target gene recognition in embryonic sensory neurons

31 March 2020

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Preclinical in vivo study of new insulin-like growth factor-I receptor--specific inhibitor in Ewing's sarcoma

31 March 2020

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EWS/FLI1-induced manic fringe renders NIH 3T3 cells tumorigenic

31 March 2020

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Ewing sarcoma 11;22 translocation produces a chimeric transcription factor that requires the DNA-binding domain encoded by FLI1 for transformation.

31 March 2020

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Requirement for Brn-3.0 in differentiation and survival of sensory and motor neurons

31 March 2020

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Identification of p21WAF1/CIP1 as a direct target of EWS-Fli1 oncogenic fusion protein

31 March 2020

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Distinct promoter elements mediate the co-operative effect of Brn-3a and p53 on the p21 promoter and their antagonism on the Bax promoter

31 March 2020

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EWS/FLI-1 silencing and gene profiling of Ewing cells reveal downstream oncogenic pathways and a crucial role for repression of insulin-like growth factor binding protein 3.

31 March 2020

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Development of Ewing's sarcoma from primary bone marrow-derived mesenchymal progenitor cells

31 March 2020

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EWS-FLI-1 expression triggers a Ewing's sarcoma initiation program in primary human mesenchymal stem cells.

31 March 2020

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The Ews/Fli-1 fusion gene switches the differentiation program of neuroblastomas to Ewing sarcoma/peripheral primitive neuroectodermal tumors

31 March 2020

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Expression profiling of EWS/FLI identifies NKX2.2 as a critical target gene in Ewing's sarcoma

31 March 2020

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EWS-Fli1 antisense oligodeoxynucleotide inhibits proliferation of human Ewing's sarcoma and primitive neuroectodermal tumor cells

31 March 2020

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Mouse Brn-3 family of POU transcription factors: a new aminoterminal domain is crucial for the oncogenic activity of Brn-3a

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31 March 2020

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Targeted deletion of the mouse POU domain gene Brn-3a causes selective loss of neurons in the brainstem and trigeminal ganglion, uncoordinated limb movement, and impaired suckling

31 March 2020

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31 March 2020

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Expression of the EWS/FLI-1 oncogene in murine primary bone-derived cells Results in EWS/FLI-1-dependent, ewing sarcoma-like tumors

31 March 2020

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Selective usage of D-Type cyclins by Ewing's tumors and rhabdomyosarcomas

31 March 2020

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31 March 2020

Identifiers

DOI

10.1038/ONC.2010.72

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20348952%20AND%20SRC:MED&resulttype=core&format=json

29 January 2020

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