Exploring an Orbitrap Analyzer for the Characterization of Intact Antibodies by Native Mass Spectrometry (Q57666099)

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18 February 2020

title

Exploring an orbitrap analyzer for the characterization of intact antibodies by native mass spectrometry (English)

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18 February 2020

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Alexander Alexeyevich Makarov

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18 February 2020

Albert J.R. Heck

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author name string

Sara Rosati

1

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18 February 2020

Eugen Damoc

5

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18 February 2020

Eduard Denisov

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18 February 2020

Rebecca J Rose

2

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18 February 2020

Natalie J Thompson

3

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18 February 2020

Esther van Duijn

4

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language of work or name

English

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publication date

22 November 2012

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Angewandte Chemie International Edition

18 February 2020

published in

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volume

51

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issue

52

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page(s)

12992-12996

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Antibody-based therapeutics to watch in 2011.

18 February 2020

cites work

1 reference

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Mass measurement and top-down HPLC/MS analysis of intact monoclonal antibodies on a hybrid linear quadrupole ion trap-Orbitrap mass spectrometer

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Mass spectrometry for structural characterization of therapeutic antibodies

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Mass spectrometric determination of disulfide linkages in recombinant therapeutic proteins using online LC-MS with electron-transfer dissociation

21 January 2018

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Resolving disulfide structural isoforms of IgG2 monoclonal antibodies by ion mobility mass spectrometry

21 January 2018

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An innovative approach for the characterization of the isoforms of a monoclonal antibody product

21 January 2018

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Automatic disulfide bond assignment using a1 ion screening by mass spectrometry for structural characterization of protein pharmaceuticals

21 January 2018

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Native mass spectrometry: a bridge between interactomics and structural biology

21 January 2018

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Extending mass spectrometry contribution to therapeutic monoclonal antibody lead optimization: characterization of immune complexes using noncovalent ESI-MS.

21 January 2018

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Quantitative Analysis of the Interaction Strength and Dynamics of Human IgG4 Half Molecules by Native Mass Spectrometry

21 January 2018

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Qualitative and semiquantitative analysis of composite mixtures of antibodies by native mass spectrometry.

21 January 2018

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A comparison of three techniques for quantitative carbohydrate analysis used in characterization of therapeutic antibodies

21 January 2018

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The way forward, enhanced characterization of therapeutic antibody glycosylation: comparison of three level mass spectrometry-based strategies.

21 January 2018

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Electrospray ionization quadrupole ion-mobility time-of-flight mass spectrometry as a tool to distinguish the lot-to-lot heterogeneity in N-glycosylation profile of the therapeutic monoclonal antibody trastuzumab.

21 January 2018

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Native intact mass determination of antibodies conjugated with monomethyl Auristatin E and F at interchain cysteine residues.

21 January 2018

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High-sensitivity Orbitrap mass analysis of intact macromolecular assemblies

21 January 2018

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Post-translational modifications differentially affect IgG1 conformation and receptor binding.

21 January 2018

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Enhanced antibody half-life improves in vivo activity

21 January 2018

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Unit mass baseline resolution for an intact 148 kDa therapeutic monoclonal antibody by Fourier transform ion cyclotron resonance mass spectrometry

21 January 2018

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Antibody cocktails: next-generation biopharmaceuticals with improved potency

21 January 2018

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Generation of stable cell clones expressing mixtures of human antibodies

21 January 2018

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Effects of antibody affinity and antigen valence on molecular forms of immune complexes

21 January 2018

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Probing molecular interactions in intact antibody: antigen complexes, an electrospray time-of-flight mass spectrometry approach

21 January 2018

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Mass spectrometric analysis of intact human monoclonal antibody aggregates fractionated by size-exclusion chromatography.

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1002/ANIE.201206745

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:23172610%20AND%20SRC:MED&resulttype=core&format=json

18 February 2020

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