SOX2 gene amplification and protein overexpression are associated with better outcome in squamous cell lung cancer (Q57693361)

Ralf Mikut

8

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Mark Rubin

Mark A Rubin

15

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Matthew Meyerson

14

Matthew Meyerson

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Holger Moch

10

Holger Moch

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author name string

Theresia Wilbertz

1

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Patrick Wagner

2

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Karen Petersen

3

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Ann-Cathrin Stiedl

4

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Veit J Scheble

5

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Sebastian Maier

6

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Markus Reischl

7

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Nasser K Altorki

9

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Falko Fend

11

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Annette Staebler

12

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Adam J Bass

13

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Alex Soltermann

16

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Sven Perner

Chromosomal abnormalities in cancer

18

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publication date

1 April 2011

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published in

Modern Pathology

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volume

24

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issue

7

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page(s)

944-953

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cites work

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Genomic profiling identifies TITF1 as a lineage-specific oncogene amplified in lung cancer

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TTF1 expression in non-small cell lung carcinoma: association with TTF1 gene amplification and improved survival.

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Clinical significance of TTF-1 protein expression and TTF-1 gene amplification in lung adenocarcinoma

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Role of chromosome 3q amplification in lung cancer

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SOX2 is an amplified lineage-survival oncogene in lung and esophageal squamous cell carcinomas

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SOX2 is an oncogene activated by recurrent 3q26.3 amplifications in human lung squamous cell carcinomas

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Pairing SOX off: with partners in the regulation of embryonic development

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Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors

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Multipotent cell lineages in early mouse development depend on SOX2 function

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The Yin and Yang of Sox proteins: Activation and repression in development and disease

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Sox2 is important for two crucial processes in lung development: branching morphogenesis and epithelial cell differentiation

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Multiple dose-dependent roles for Sox2 in the patterning and differentiation of anterior foregut endoderm

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Sex determining region Y-Box 2 (SOX2) is a potential cell-lineage gene highly expressed in the pathogenesis of squamous cell carcinomas of the lung

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Sox2 expression in pulmonary non-small cell and neuroendocrine carcinomas

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Sox2 protein expression is an independent poor prognostic indicator in stage I lung adenocarcinoma.

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Progressive 3q amplification consistently targets SOX2 in preinvasive squamous lung cancer

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Recurrent copy number gain of transcription factor SOX2 and corresponding high protein expression in oral squamous cell carcinoma.

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SOX2 is highly expressed in squamous cell carcinomas of the gastrointestinal tract

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Evidence that SOX2 overexpression is oncogenic in the lung

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SOX2 in gastric carcinoma, but not Hath1, is related to patients' clinicopathological features and prognosis

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An embryonic stem cell-like gene expression signature in poorly differentiated aggressive human tumors

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Functional evidence that the self-renewal gene NANOG regulates human tumor development

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The increasing complexity of the cancer stem cell paradigm

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SOX2 amplification is a common event in squamous cell carcinomas of different organ sites

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7 January 2021

Expression of the embryonic stem cell marker SOX2 in early-stage breast carcinoma

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7 January 2021

Prognostic significance of epithelial-mesenchymal and mesenchymal-epithelial transition protein expression in non-small cell lung cancer

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7 January 2021

SOX2 in squamous cell carcinoma: amplifying a pleiotropic oncogene along carcinogenesis

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7 January 2021