histone deacetylase 2 (Q5773155)

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mammalian protein found in Homo sapiens
  • YY1 transcription factor-binding protein
  • transcriptional regulator homolog RPD3
  • HDAC2
  • YY1-associated factor 1
  • Histone deacetylase 2
edit
Language Label Description Also known as
English
histone deacetylase 2
mammalian protein found in Homo sapiens
  • YY1 transcription factor-binding protein
  • transcriptional regulator homolog RPD3
  • HDAC2
  • YY1-associated factor 1
  • Histone deacetylase 2

Statements

molecular function
protein binding
determination method
IPI
46 references
retrieved
8 April 2019
stated in
Complementary quantitative proteomics reveals that transcription factor AP-4 mediates E-box-dependent complex formation for transcriptional repression of HDM2
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
The growth suppressor PML represses transcription by functionally and physically interacting with histone deacetylases
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Histone deacetylase 10 regulates DNA mismatch repair and may involve the deacetylation of MutS homolog 2.
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Histone deacetylase interacts directly with DNA topoisomerase II
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
The subcellular distribution and function of MTA1 in cancer differentiation
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Endosomal adaptor proteins APPL1 and APPL2 are novel activators of beta-catenin/TCF-mediated transcription
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
The transcriptional repressor Sp3 is associated with CK2-phosphorylated histone deacetylase 2
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
SUMOylation and SUMO-interacting motif (SIM) of metastasis tumor antigen 1 (MTA1) synergistically regulate its transcriptional repressor function
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Chfr is linked to tumour metastasis through the downregulation of HDAC1
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate.
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Maintenance of silent chromatin through replication requires SWI/SNF-like chromatin remodeler SMARCAD1
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
A BEN-domain-containing protein associates with heterochromatin and represses transcription
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
E3 ubiquitin ligase COP1 regulates the stability and functions of MTA1
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Modification of de novo DNA methyltransferase 3a (Dnmt3a) by SUMO-1 modulates its interaction with histone deacetylases (HDACs) and its capacity to repress transcription
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
FE65 binds Teashirt, inhibiting expression of the primate-specific caspase-4
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Dual role of NRSF/REST in activation and repression of the glucocorticoid response
GOA
curator
UniProt
UniProt protein ID
Q92769
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation of snail modulates the cytokinome of cancer cells to enhance the recruitment of macrophages
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Unraveling the hidden catalytic activity of vertebrate class IIa histone deacetylases
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Daxx and histone deacetylase II associate with chromatin through an interaction with core histones and the chromatin-associated protein Dek
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Nucleophosmin acts as a novel AP2alpha-binding transcriptional corepressor during cell differentiation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Orphan nuclear receptor Nur77 induces zinc finger protein GIOT-1 gene expression, and GIOT-1 acts as a novel corepressor of orphan nuclear receptor SF-1 via recruitment of HDAC2
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Acetylation-dependent oncogenic activity of metastasis-associated protein 1 co-regulator
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Breast cancer metastasis suppressor 1 (BRMS1) is stabilized by the Hsp90 chaperone
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Dysfunction of the Reciprocal Feedback Loop between GATA3- and ZEB2-Nucleated Repression Programs Contributes to Breast Cancer Metastasis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
A comprehensive resource of interacting protein regions for refining human transcription factor networks
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Recruitment of chromatin-modifying enzymes by CTIP2 promotes HIV-1 transcriptional silencing
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
The steroid receptor RNA activator protein is recruited to promoter regions and acts as a transcriptional repressor
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
The ErbB3 binding protein Ebp1 interacts with Sin3A to repress E2F1 and AR-mediated transcription
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Human Sin3 deacetylase and trithorax-related Set1/Ash2 histone H3-K4 methyltransferase are tethered together selectively by the cell-proliferation factor HCF-1
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Isolation and characterization of a novel class II histone deacetylase, HDAC10
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Chemoproteomics profiling of HDAC inhibitors reveals selective targeting of HDAC complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
NuRD-ZNF827 recruitment to telomeres creates a molecular scaffold for homologous recombination.
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
The functional interactome landscape of the human histone deacetylase family
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Methyl-CpG binding domain 1 (MBD1) interacts with the Suv39h1-HP1 heterochromatic complex for DNA methylation-based transcriptional repression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Large-scale identification of c-MYC-associated proteins using a combined TAP/MudPIT approach
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Regulatory factor for X-box family proteins differentially interact with histone deacetylases to repress collagen alpha2(I) gene (COL1A2) expression
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Leucine zipper domain is required for Kaposi sarcoma-associated herpesvirus (KSHV) K-bZIP protein to interact with histone deacetylase and is important for KSHV replication
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
Differential distribution of unmodified and phosphorylated histone deacetylase 2 in chromatin
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
retrieved
8 April 2019
stated in
LSD1-mediated epigenetic modification is required for TAL1 function and hematopoiesis
GOA
curator
British Heart Foundation
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q92769
determination method
IPI
cell component
biological process
physically interacts with
Gene Atlas image
PBB GE HDAC2 201833 at fs.png
732 × 530; 12 KB
0 references

Identifiers

MeSH descriptor ID
D056464
subject named as
Histone Deacetylase 2
0 references
 
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