Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias (Q57734345)

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English	Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias	article

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Pediatric acute myeloid leukemia with NPM1 mutations is characterized by a gene expression profile with dysregulated HOX gene expression distinct from MLL-rearranged leukemias (English)

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acute myeloid leukemia

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childhood acute myeloid leukemia

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Charles G. Mullighan

1

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author name string

A Kennedy

2

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X Zhou

3

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I Radtke

4

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L A Phillips

5

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S A Shurtleff

6

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J R Downing

7

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publication date

28 June 2007

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21

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9

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2000-2009

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https://scigraph.springernature.com/pub.10.1038/sj.leu.2404808

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Activating mutations of RTK/ras signal transduction pathway in pediatric acute myeloid leukemia

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Mutations in KIT and RAS are frequent events in pediatric core-binding factor acute myeloid leukemia

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Prognostic significance of FLT3 mutations in pediatric non-promyelocytic acute myeloid leukemia

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Prognostic significance of partial tandem duplications of the MLL gene in adult patients 16 to 60 years old with acute myeloid leukemia and normal cytogenetics: a study of the Acute Myeloid Leukemia Study Group Ulm.

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Prevalence, clinical profile, and prognosis of NPM mutations in AML with normal karyotype

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Mutant nucleophosmin (NPM1) predicts favorable prognosis in younger adults with acute myeloid leukemia and normal cytogenetics: interaction with other gene mutations

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Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype

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Nucleophosmin gene mutations are predictors of favorable prognosis in acute myelogenous leukemia with a normal karyotype

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Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML): association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance

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Major nucleolar proteins shuttle between nucleus and cytoplasm

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ARF impedes NPM/B23 shuttling in an Mdm2-sensitive tumor suppressor pathway

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Nucleophosmin regulates the stability and transcriptional activity of p53

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Fusion of a kinase gene, ALK, to a nucleolar protein gene, NPM, in non-Hodgkin's lymphoma.

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Role of the nucleophosmin (NPM) portion of the non-Hodgkin's lymphoma-associated NPM-anaplastic lymphoma kinase fusion protein in oncogenesis

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Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML.

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Gene expression profiling of pediatric acute myelogenous leukemia

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Classification of pediatric acute lymphoblastic leukemia by gene expression profiling

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MLL translocations specify a distinct gene expression profile that distinguishes a unique leukemia

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Successive clinical trials for childhood acute myeloid leukemia at St Jude Children's Research Hospital, from 1980 to 2000.

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Proposed revised criteria for the classification of acute myeloid leukemia. A report of the French-American-British Cooperative Group

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A direct approach to false discovery rates

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Statistical significance for genomewide studies

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Design and analysis of randomized clinical trials requiring prolonged observation of each patient. II. analysis and examples

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The role of HOX genes in myeloid leukemogenesis

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Hox regulation of normal and leukemic hematopoietic stem cells.

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Hox expression in AML identifies a distinct subset of patients with intermediate cytogenetics

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Gene expression signatures in MLL-rearranged T-lineage and B-precursor acute leukemias: dominance of HOX dysregulation.

1 reference

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Overexpression of HOXB3 in hematopoietic cells causes defective lymphoid development and progressive myeloproliferation

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Overexpression of HOXA10 in murine hematopoietic cells perturbs both myeloid and lymphoid differentiation and leads to acute myeloid leukemia

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Hoxa9 transforms primary bone marrow cells through specific collaboration with Meis1a but not Pbx1b

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Defining roles for HOX and MEIS1 genes in induction of acute myeloid leukemia

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HOXB6 overexpression in murine bone marrow immortalizes a myelomonocytic precursor in vitro and causes hematopoietic stem cell expansion and acute myeloid leukemia in vivo

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Expression pattern of HOXB6 homeobox gene in myelomonocytic differentiation and acute myeloid leukemia.

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Mutated nucleophosmin detects clonal multilineage involvement in acute myeloid leukemia: Impact on WHO classification

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Overexpression of HOXB4 in hematopoietic cells causes the selective expansion of more primitive populations in vitro and in vivo

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HOXB4-induced expansion of adult hematopoietic stem cells ex vivo.

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Nucleophosmin and cancer

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Immunohistochemistry predicts nucleophosmin (NPM) mutations in acute myeloid leukemia

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Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance

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CEBPalpha mutations in childhood acute myeloid leukemia

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Screening for MLL tandem duplication in 387 unselected patients with AML identify a prognostically unfavorable subset of AML

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Clinical characteristics and prognostic implications of NPM1 mutations in acute myeloid leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Nucleophosmin mutations in childhood acute myelogenous leukemia with normal karyotype

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

NPM mutations in acute myelogenous leukemia

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

inferred from DOI database lookup

Classification, subtype discovery, and prediction of outcome in pediatric acute lymphoblastic leukemia by gene expression profiling

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

7 January 2021

based on heuristic

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Nonparametric Estimation from Incomplete Observations

1 reference

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Expression of HOX genes, HOX cofactors, and MLL in phenotypically and functionally defined subpopulations of leukemic and normal human hematopoietic cells

1 reference

https://api.crossref.org/works/10.1038%2FSJ.LEU.2404808

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Identifiers

10.1038/SJ.LEU.2404808

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Europe PubMed Central

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1 January 2020

1 reference

Europe PubMed Central

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1 January 2020

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