Pivotal Advance: Phospholipids determine net membrane surface charge resulting in differential localization of active Rac1 and Rac2 (Q57986700)

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13 February 2020

title

Pivotal Advance: Phospholipids determine net membrane surface charge resulting in differential localization of active Rac1 and Rac2 (English)

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1

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13 February 2020

Michael Glogauer

series ordinal

2

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13 February 2020

author name string

Marco A. O. Magalhaes

series ordinal

1

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publication date

1 April 2010

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19955208%20AND%20SRC:MED&resulttype=core&format=json

Journal of Leukocyte Biology

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published in

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volume

87

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issue

4

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page(s)

545-555

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Lipid signaling and the modulation of surface charge during phagocytosis

13 February 2020

cites work

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The electrostatic properties of membranes

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Membrane phospholipid asymmetry and signal transduction

21 January 2018

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PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane

21 January 2018

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Membrane phosphatidylserine regulates surface charge and protein localization

21 January 2018

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The myristoyl-electrostatic switch: a modulator of reversible protein-membrane interactions

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Expression and translocation of fluorescent-tagged p21-activated kinase-binding domain and PH domain of protein kinase B during murine neutrophil chemotaxis.

21 January 2018

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Lipid products of phosphoinositide 3-kinase interact with Rac1 GTPase and stimulate GDP dissociation.

21 January 2018

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Two pathways of activation of the superoxide-generating NADPH oxidase of phagocytes in vitro--distinctive effects of inhibitors

21 January 2018

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Isoform-specific membrane targeting mechanism of Rac during Fc gamma R-mediated phagocytosis: positive charge-dependent and independent targeting mechanism of Rac to the phagosome

21 January 2018

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The polybasic region of Ras and Rho family small GTPases: a regulator of protein interactions and membrane association and a site of nuclear localization signal sequences

21 January 2018

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Cell migration and signaling specificity is determined by the phosphatidylserine recognition motif of Rac1.

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The Rac1 C-terminal polybasic region regulates the nuclear localization and protein degradation of Rac1.

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Receptor activation alters inner surface potential during phagocytosis

21 January 2018

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A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane

21 January 2018

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Rac1 is the small GTPase responsible for regulating the neutrophil chemotaxis compass

21 January 2018

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Rac1 and Rac2 differentially regulate actin free barbed end formation downstream of the fMLP receptor

21 January 2018

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Differential localization of Rho GTPases in live cells: regulation by hypervariable regions and RhoGDI binding

21 January 2018

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Endomembrane trafficking of ras: the CAAX motif targets proteins to the ER and Golgi

21 January 2018

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Visualization of phosphoinositides that bind pleckstrin homology domains: calcium- and agonist-induced dynamic changes and relationship to myo-[3H]inositol-labeled phosphoinositide pools

21 January 2018

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The PX domains of p47phox and p40phox bind to lipid products of PI(3)K

21 January 2018

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Cdc42, Rac1, and Rac2 display distinct patterns of activation during phagocytosis.

21 January 2018

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Membrane trafficking of heterotrimeric G proteins via the endoplasmic reticulum and Golgi

21 January 2018

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Rac GTPase isoform-specific regulation of NADPH oxidase and chemotaxis in murine neutrophils in vivo. Role of the C-terminal polybasic domain.

21 January 2018

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Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils

21 January 2018

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Rac1 deletion in mouse neutrophils has selective effects on neutrophil functions.

21 January 2018

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Deficiency of the hematopoietic cell-specific Rho family GTPase Rac2 is characterized by abnormalities in neutrophil function and host defense

21 January 2018

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Distinct roles of class I and class III phosphatidylinositol 3-kinases in phagosome formation and maturation

21 January 2018

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Restricted accumulation of phosphatidylinositol 3-kinase products in a plasmalemmal subdomain during Fc gamma receptor-mediated phagocytosis

21 January 2018

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Localization of Rac2 via the C terminus and aspartic acid 150 specifies superoxide generation, actin polarity and chemotaxis in neutrophils.

21 January 2018

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Activation of the superoxide-generating NADPH oxidase by chimeric proteins consisting of segments of the cytosolic component p67(phox) and the small GTPase Rac1.

21 January 2018

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A prenylated p67phox-Rac1 chimera elicits NADPH-dependent superoxide production by phagocyte membranes in the absence of an activator and of p47phox: conversion of a pagan NADPH oxidase to monotheism

21 January 2018

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Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phosph

21 January 2018

1 reference

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Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras

21 January 2018

1 reference

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Liposomes comprising anionic but not neutral phospholipids cause dissociation of Rac(1 or 2) x RhoGDI complexes and support amphiphile-independent NADPH oxidase activation by such complexes

21 January 2018

1 reference

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Contribution of phosphatidylserine to membrane surface charge and protein targeting during phagosome maturation.

21 January 2018

1 reference

https://api.crossref.org/works/10.1189%2FJLB.0609390

Human monocytes use Rac1, not Rac2, in the NADPH oxidase complex

21 January 2018

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Pathogen destruction versus intracellular survival: the role of lipids as phagosomal fate determinants

21 January 2018

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21 January 2018

Identifiers

DOI

10.1189/JLB.0609390

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:19955208%20AND%20SRC:MED&resulttype=core&format=json

13 February 2020

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