PDE 4 inhibitors: the use of molecular cloning in the design and development of novel drugs (Q57994824)

1

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Martin Perry

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Graham Warrellow

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Rodger Allen

On the medical history of xanthines and other remedies for asthma: a tribute to HH Salter

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publication date

March 1997

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published in

Drug Discovery Today

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volume

2

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issue

3

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page(s)

89-101

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cites work

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Selective inhibition of one of the cyclic AMP phosphodiesterases from rat brain by the neurotropic compound rolipram.

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Rolipram in major depressive disorder: results of a double-blind comparative study with imipramine

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Is phosphodiesterase inhibition a new mechanism of antidepressant action? A double blind double-dummy study between rolipram and desipramine in hospitalized major and/or endogenous depressives

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EEG mapping and psychopharmacological studies with denbufylline in SDAT and MID

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Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster.

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Characterization of the memory gene dunce of Drosophila melanogaster

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A family of human phosphodiesterases homologous to the dunce learning and memory gene product of Drosophila melanogaster are potential targets for antidepressant drugs

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Differential CNS expression of alternative mRNA isoforms of the mammalian genes encoding cAMP-specific phosphodiesterases

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Identification of cyclic AMP-phosphodiesterase variants from the PDE4D gene expressed in human peripheral mononuclear cells

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Expression and regulation of human and rat phosphodiesterase type IV isogenes

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Suppression of eosinophil function by RP 73401, a potent and selective inhibitor of cyclic AMP-specific phosphodiesterase: comparison with rolipram

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Characterization of two human cAMP-specific phosphodiesterase subtypes expressed in baculovirus-infected insect cells

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Purification of cAMP-specific phosphodiesterase from rat heart by affinity chromatography on immobilized rolipram

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Effects of solubilization and vanadate/glutathione complex on inhibitor potencies against eosinophil cyclic AMP-specific phosphodiesterase

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Stereospecific binding of the antidepressant rolipram to brain protein structures

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Association of the anti-inflammatory activity of phosphodiesterase 4 (PDE4) inhibitors with either inhibition of PDE4 catalytic activity or competition for [3H]rolipram binding

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Differential effects of non-selective and selective phosphodiesterase inhibitors on human eosinophil functions

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Evidence that cyclic AMP phosphodiesterase inhibitors suppress TNF alpha generation from human monocytes by interacting with a 'low-affinity' phosphodiesterase 4 conformer

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Anti-inflammatory and bronchodilator properties of RP 73401, a novel and selective phosphodiesterase type IV inhibitor

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Comparison of the effects of selective inhibitors of phosphodiesterase types III and IV in airway smooth muscle with differing beta-adrenoceptor subtypes

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The inhibition of antigen-induced eosinophilia and bronchoconstriction by CDP840, a novel stereo-selective inhibitor of phosphodiesterase type 4.

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Effect of the glucocorticosteroid budesonide and a novel phosphodiesterase type 4 inhibitor CDP840 on antigen-induced airway responses in neonatally immunised rabbits

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Effects of rolipram on responses to acute and chronic antigen exposure in monkeys.

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Effects of theophylline and rolipram on antigen-induced airway responses in neonatally immunized rabbits

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Inhibition of bronchospasm and ozone-induced airway hyperresponsiveness in the guinea-pig by CDP840, a novel phosphodiesterase type 4 inhibitor

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7 January 2021

Rolipram, but not siguazodan or zaprinast, inhibits the excitatory noncholinergic neurotransmission in guinea-pig bronchi

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Biarylcarboxylic acids and -amides: inhibition of phosphodiesterase type IV versus [3H]rolipram binding activity and their relationship to emetic behavior in the ferret

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7 January 2021

Criteria for judging proposals for national health care reform with respect to therapeutics

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