Autoantibodies to the functionally active RING-domain of Ro52/SSA are associated with disease activity in patients with lupus (Q58190143)

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object named as

M Wahren-Herlenius

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author name string

M Kvarnström

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V Dzikaite-Ottosson

2

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L Ottosson

3

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JT Gustafsson

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I Gunnarsson

Assessment of patients with systemic lupus erythematosus and the use of lupus disease activity indices

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publication date

April 2013

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published in

Lupus

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volume

22

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issue

5

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page(s)

477-485

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Themes and variations on ubiquitylation

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Anti-Ro52 autoantibodies from patients with Sjögren's syndrome inhibit the Ro52 E3 ligase activity by blocking the E3/E2 interface.

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Self protection from anti-viral responses--Ro52 promotes degradation of the transcription factor IRF7 downstream of the viral Toll-Like receptors

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Loss of the lupus autoantigen Ro52/Trim21 induces tissue inflammation and systemic autoimmunity by disregulating the IL-23-Th17 pathway

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Elevated triglycerides and low levels of high-density lipoprotein as markers of disease activity in association with up-regulation of the tumor necrosis factor alpha/tumor necrosis factor receptor system in systemic lupus erythematosus

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Structurally derived mutations define congenital heart block-related epitopes within the 200-239 amino acid stretch of the Ro52 protein

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Activation of type I interferon system in systemic lupus erythematosus correlates with disease activity but not with antiretroviral antibodies

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