Epidermal Growth Factor Receptor Targeting Prevents Uncoupling of the Grb2-SOS Complex (Q58197216)

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15 October 2019

title

Epidermal growth factor receptor targeting prevents uncoupling of the Grb2-SOS complex (English)

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15 October 2019

6

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15 October 2019

author name string

K H Holt

1

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15 October 2019

S B Waters

2

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15 October 2019

S Okada

3

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15 October 2019

K Yamauchi

4

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15 October 2019

S J Decker

5

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15 October 2019

D G Motto

7

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15 October 2019

G A Koretzky

8

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15 October 2019

J E Pessin

9

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15 October 2019

language of work or name

English

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publication date

1 April 1996

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Journal of Biological Chemistry

15 October 2019

number of pages

7

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based on heuristic

inferred from page(s)

published in

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15 October 2019

volume

271

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15 October 2019

issue

14

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15 October 2019

page(s)

8300-8306

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Insulin receptor substrate 1 and 2 (IRS1 and IRS2): what a tangled web we weave

15 October 2019

cites work

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The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

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The SH2 and SH3 domains of mammalian Grb2 couple the EGF receptor to the Ras activator mSos1

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Pleiotropic insulin signals are engaged by multisite phosphorylation of IRS-1

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Human Sos1: a guanine nucleotide exchange factor for Ras that binds to GRB2

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Grb2 mediates the EGF-dependent activation of guanine nucleotide exchange on Ras

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Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

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The function of GRB2 in linking the insulin receptor to Ras signaling pathways

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Membrane targeting of the nucleotide exchange factor Sos is sufficient for activating the Ras signaling pathway.

21 January 2018

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Membrane-targeting potentiates guanine nucleotide exchange factor CDC25 and SOS1 activation of Ras transforming activity

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Binding of the Ras activator son of sevenless to insulin receptor substrate-1 signaling complexes

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Insulin and epidermal growth factor influence guanine nucleotide-releasing factor by distinct mechanisms

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In vivo functional analysis of the Ras exchange factor son of sevenless

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Functional Roles for the Pleckstrin and Dbl Homology Regions in the Ras Exchange Factor Son-of-sevenless

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The Grb2 binding domain of mSos1 is not required for downstream signal transduction

21 January 2018

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Complexes of Ras.GTP with Raf-1 and mitogen-activated protein kinase kinase

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Complex formation between RAS and RAF and other protein kinases

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Mammalian Ras interacts directly with the serine/threonine kinase Raf

21 January 2018

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Direct interaction of Ras and the amino-terminal region of Raf-1 in vitro

21 January 2018

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Normal and oncogenic p21ras proteins bind to the amino-terminal regulatory domain of c-Raf-1

21 January 2018

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Raf-1 forms a stable complex with Mek1 and activates Mek1 by serine phosphorylation

21 January 2018

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The SRF accessory protein Elk-1 contains a growth factor-regulated transcriptional activation domain

21 January 2018

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Insulin-stimulated disassociation of the SOS-Grb2 complex

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Negative Feedback Regulation and Desensitization of Insulin- and Epidermal Growth Factor-stimulated p21ras Activation

21 January 2018

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Desensitization of Ras Activation by a Feedback Disassociation of the SOS-Grb2 Complex

21 January 2018

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Shc isoform-specific tyrosine phosphorylation by the insulin and epidermal growth factor receptors

21 January 2018

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Association of Sos Ras exchange protein with Grb2 is implicated in tyrosine kinase signal transduction and transformation

21 January 2018

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Rescue of signaling by a chimeric protein containing the cytoplasmic domain of CD45.

21 January 2018

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Involvement of Shc in insulin- and epidermal growth factor-induced activation of p21ras

21 January 2018

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A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

21 January 2018

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21 January 2018

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21 January 2018

Identifiers

DOI

10.1074/JBC.271.14.8300

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8626525%20AND%20SRC:MED&resulttype=core&format=json

15 October 2019

1 reference