Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF/VEGFR2(KDR) pathway and prognosis (Q58211884)

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Efthimios Sivridis

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Kevin C. Gatter

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Helen Turley

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Michael I. Koukourakis

On the Origin of Cancer Cells

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language of work or name

English

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publication date

December 2006

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published in

Gynecologic Oncology

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volume

103

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issue

3

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page(s)

912-918

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cites work

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Akt stimulates aerobic glycolysis in cancer cells

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Regulation of hypoxia-inducible factor-1alpha protein level during hypoxic conditions by the phosphatidylinositol 3-kinase/Akt/glycogen synthase kinase 3beta pathway in HepG2 cells

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Hypoxia Response Elements in the Aldolase A, Enolase 1, and Lactate Dehydrogenase A Gene Promoters Contain Essential Binding Sites for Hypoxia-inducible Factor 1

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Lactate dehydrogenase isoenzymes 1 and 5: differential expression by neoplastic and stromal cells in non-small cell lung cancer and other epithelial malignant tumors

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Lactate dehydrogenase-5 (LDH-5) overexpression in non-small-cell lung cancer tissues is linked to tumour hypoxia, angiogenic factor production and poor prognosis

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Lactate dehydrogenase 5 (LDH5) relates to up-regulated hypoxia inducible factor pathway and metastasis in colorectal cancer

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Causes and consequences of tumour acidity and implications for treatment

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Protection from oxidative stress-induced apoptosis in cortical neuronal cultures by iron chelators is associated with enhanced DNA binding of hypoxia-inducible factor-1 and ATF-1/CREB and increased expression of glycolytic enzymes, [...]

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Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma

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The angiogenic ?vascular endothelial growth factor/flk-1(KDR) receptor? pathway in patients with endometrial carcinoma

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Phosphorylated KDR expression in endometrial cancer cells relates to HIF1α/VEGF pathway and unfavourable prognosis

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Prognostic factors in pancreatic carcinoma: serum LDH levels predict survival in metastatic disease

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Survival and prognostic stratification of 670 patients with advanced renal cell carcinoma.

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Multivariate analysis of prognostic factors in patients with glioblastoma

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Elevated tumor lactate concentrations predict for an increased risk of metastases in head-and-neck cancer

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Prognostic features and treatment outcome in locoregionally advanced nasopharyngeal carcinoma following concurrent chemotherapy and radiotherapy.

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Activation of vascular endothelial growth factor gene transcription by hypoxia-inducible factor 1

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Monocarboxylate transporter MCT1 is a target for immunosuppression

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The angiogenic receptor KDR is widely distributed in human tissues and tumours and relocates intracellularly on phosphorylation. An immunohistochemical study

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Phosphorylated KDR is expressed in the neoplastic and stromal elements of human renal tumours and shuttles from cell membrane to nucleus.

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Hypoxia-inducible factor 1 activation by aerobic glycolysis implicates the Warburg effect in carcinogenesis

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Lymphvascular space involvement: an independent prognostic factor in endometrial cancer

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