CD40 activation in vivo overcomes peptide-induced peripheral cytotoxic T-lymphocyte tolerance and augments anti-tumor vaccine efficacy (Q58235013)

1

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Annemieke Th. den Boer

2

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Ellen I.H. van der Voort

4

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Ton N.M. Schumacher

5

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Cornelis J.M. Melief

6

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Rienk Offringa

7

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Rene E. M. Toes

https://scigraph.springernature.com/pub.10.1038/10495

8

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language of work or name

English

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publication date

July 1999

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published in

Nature Medicine

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volume

5

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page(s)

774-779

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issue

7

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exact match

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cites work

T cell priming versus T cell tolerance induced by synthetic peptides

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Vaccination with cytotoxic T lymphocyte epitope-containing peptide protects against a tumor induced by human papillomavirus type 16-transformed cells

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Peptide-induced T-cell tolerance to prevent autoimmune diabetes in a transgenic mouse model

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Peptide antigen treatment of naive and virus-immune mice: antigen-specific tolerance versus immunopathology

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Peptide vaccination can lead to enhanced tumor growth through specific T-cell tolerance induction.

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A fail-safe mechanism for maintaining self-tolerance

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CD4+ T cell help impairs CD8+ T cell deletion induced by cross-presentation of self-antigens and favors autoimmunity

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T-cell help for cytotoxic T lymphocytes is mediated by CD40-CD40L interactions.

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Help for cytotoxic-T-cell responses is mediated by CD40 signalling.

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Ligation of CD40 on dendritic cells triggers production of high levels of interleukin-12 and enhances T cell stimulatory capacity: T-T help via APC activation

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A conditioned dendritic cell can be a temporal bridge between a CD4+ T-helper and a T-killer cell.

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B cells directly tolerize CD8(+) T cells

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Cytotoxic T lymphocytes raised against a subdominant epitope offered as a synthetic peptide eradicate human papillomavirus type 16-induced tumors

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Survival of mouse pancreatic islet allografts in recipients treated with allogeneic small lymphocytes and antibody to CD40 ligand.

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In vivo induction of antigen-specific transplantation tolerance to Qa1a by exposure to alloantigen in the absence of T-cell help

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Viral and bacterial infections interfere with peripheral tolerance induction and activate CD8+ T cells to cause immunopathology

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The immune responses in CD40-deficient mice: impaired immunoglobulin class switching and germinal center formation

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The SCID but not the RAG-2 gene product is required for S mu-S epsilon heavy chain class switching.

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A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene

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Phenotypic analysis of antigen-specific T lymphocytes

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Bone marrow-derived dendritic cells pulsed with synthetic tumour peptides elicit protective and therapeutic antitumour immunity

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Inflammation activates self hsp60-specific T cells

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7 January 2021

Murine experimental autoimmune hepatitis: nonspecific inflammation due to adjuvant oil

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Induction of cytotoxic T-cell response by optimal-length peptides does not require CD4+ T-cell help

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7 January 2021

Enhancement of T cell-independent immune responses in vivo by CD40 antibodies

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7 January 2021

Systemic T cell expansion during localized viral infection

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7 January 2021