Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy (Q58338072)

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10 February 2020

title

Masking of the Fc region in human IgG4 by constrained X-ray scattering modelling: implications for antibody function and therapy (English)

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10 February 2020

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X-ray scattering techniques

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3

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10 February 2020

Paul A Dalby

5

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10 February 2020

author name string

Yuki Abe

1

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10 February 2020

Jayesh Gor

2

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10 February 2020

Stephen J Perkins

4

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10 February 2020

language of work or name

English

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publication date

1 November 2010

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10 February 2020

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10 February 2020

volume

432

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10 February 2020

issue

1

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10 February 2020

page(s)

101-111

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The structural requirements for complement activation by IgG: does it hinge on the hinge?

10 February 2020

cites work

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21 January 2018

IgG4 breaking the rules

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Hybrid IgG4/IgG4 Fc antibodies form upon 'Fab-arm' exchange as demonstrated by SDS-PAGE or size-exclusion chromatography

21 January 2018

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Antibody structure, instability, and formulation

21 January 2018

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Potential aggregation prone regions in biotherapeutics: A survey of commercial monoclonal antibodies.

21 January 2018

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Location of secretory component on the Fc edge of dimeric IgA1 reveals insight into the role of secretory IgA1 in mucosal immunity

21 January 2018

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Crystal structure of a neutralizing human IGG against HIV-1: a template for vaccine design

21 January 2018

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Contrasting IgG Structures Reveal Extreme Asymmetry and Flexibility

21 January 2018

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Refined structure of an intact IgG2a monoclonal antibody

21 January 2018

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Crystallographic structure of an intact IgG1 monoclonal antibody

21 January 2018

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Protein aggregation and bioprocessing

21 January 2018

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Stability of protein pharmaceuticals: an update

21 January 2018

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Factors influencing antibody stability at solid-liquid interfaces in a high shear environment

21 January 2018

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Estimating domain orientation of two human antibody IgG4 chimeras by crystallohydrodynamics.

21 January 2018

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Solution conformation of wild-type and mutant IgG3 and IgG4 immunoglobulins using crystallohydrodynamics: possible implications for complement activation

21 January 2018

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Structure determinations of human and chimaeric antibodies by solution scattering and constrained molecular modelling.

21 January 2018

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Constrained solution scattering modelling of human antibodies and complement proteins reveals novel biological insights

21 January 2018

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The Fab and Fc fragments of IgA1 exhibit a different arrangement from that in IgG: a study by X-ray and neutron solution scattering and homology modelling

21 January 2018

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The extended multidomain solution structures of the complement protein Crry and its chimeric conjugate Crry-Ig by scattering, analytical ultracentrifugation and constrained modelling: implications for function and therapy

21 January 2018

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Solution structure determination of monomeric human IgA2 by X-ray and neutron scattering, analytical ultracentrifugation and constrained modelling: a comparison with monomeric human IgA1.

21 January 2018

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Electrostatic interactions contribute to the folded-back conformation of wild type human factor H

21 January 2018

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Crystallization and preliminary X-ray diffraction study of a chimaeric Fab' fragment of antibody binding tumour cells

21 January 2018

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Protein volumes and hydration effects. The calculations of partial specific volumes, neutron scattering matchpoints and 280-nm absorption coefficients for proteins and glycoproteins from amino acid sequences.

21 January 2018

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Sedimentation analysis of noninteracting and self-associating solutes using numerical solutions to the Lamm equation

21 January 2018

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Size-Distribution Analysis of Macromolecules by Sedimentation Velocity Ultracentrifugation and Lamm Equation Modeling

21 January 2018

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Solution structure of the complex formed between human complement C3d and full-length complement receptor type 2.

21 January 2018

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Shape and volume of anti-poly(D-alanyl) antibodies in the presence and absence of tetra-D-alanine as followed by small-angle x-ray scattering.

21 January 2018

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The SWISS-MODEL workspace: a web-based environment for protein structure homology modelling

21 January 2018

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HYDRO: a computer program for the prediction of hydrodynamic properties of macromolecules

21 January 2018

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Calculation of hydrodynamic properties of globular proteins from their atomic-level structure

21 January 2018

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Purification, properties and extended solution structure of the complex formed between human immunoglobulin A1 and human serum albumin by scattering and ultracentrifugation

21 January 2018

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Intrachain disulfide bond in the core hinge region of human IgG4.

21 January 2018

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Human IgG4 binds to IgG4 and conformationally altered IgG1 via Fc-Fc interactions.

21 January 2018

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The interpretation of protein structures: Estimation of static accessibility

21 January 2018

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The crystal structure of the globular head of complement protein C1q provides a basis for its versatile recognition properties

21 January 2018

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Anti-Inflammatory Activity of Human IgG4 Antibodies by Dynamic Fab Arm Exchange

21 January 2018

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Modulation of antigenicity related to changes in antibody flexibility upon lyophilization

21 January 2018

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Downstream processing of monoclonal antibodies--application of platform approaches

21 January 2018

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21 January 2018

Identifiers

DOI

10.1042/BJ20100641

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:20722630%20AND%20SRC:MED&resulttype=core&format=json

10 February 2020

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