Peptide/benzodiazepine hybrids as ligands of CCKA and CCKB receptors (Q58415848)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:11592053%20AND%20SRC:MED&resulttype=core&format=json

12 November 2019

title

Peptide/benzodiazepine hybrids as ligands of CCKA and CCKB receptors (English)

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Peptide/benzodiazepine hybrids as ligands of CCK(A) and CCK(B) receptors (English)

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12 November 2019

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7

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12 November 2019

Luis Moroder

9

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12 November 2019

4

Daniel Fourmy

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author name string

Achim Escherich

1

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J�rgen Lutz

2

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Chantal Escrieut

3

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A. Stephanie van Neuren

5

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Gerhard M�ller

6

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Andrea Schafferhans

7

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Gerhard Klebe

8

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Luis Moroder

9

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Escherich A

1

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12 November 2019

Lutz J

2

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12 November 2019

Escrieut C

3

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12 November 2019

Fourmy D

4

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12 November 2019

van Neuren AS

5

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12 November 2019

Müller G

6

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12 November 2019

Klebe G

8

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12 November 2019

publication date

2000

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1 January 2000

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12 November 2019

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12 November 2019

volume

56

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12 November 2019

issue

2

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12 November 2019

page(s)

55-76

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Biological actions of cholecystokinin

12 November 2019

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Biology of gut cholecystokinin and gastrin receptors

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The peripheral cholecystokinin receptors

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Characterization of Receptors for Cholecystokinin and Related Peptides in Mouse Cerebral Cortex

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Direct demonstration of three different states of the pancreatic cholecystokinin receptor

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Locating ligand-binding sites in 7TM receptors by protein engineering.

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The role of the cholecystokinin-B/gastrin receptor transmembrane domains in determining affinity for subtype-selective ligands

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His381 of the rat CCKB receptor is essential for CCKB versus CCKA receptor antagonist selectivity

21 January 2018

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A segment of five amino acids in the second extracellular loop of the cholecystokinin-B receptor is essential for selectivity of the peptide agonist gastrin

21 January 2018

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Identification of two amino acids of the human cholecystokinin-A receptor that interact with the N-terminal moiety of cholecystokinin.

21 January 2018

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Met-195 of the cholecystokinin-A receptor interacts with the sulfated tyrosine of cholecystokinin and is crucial for receptor transition to high affinity state

21 January 2018

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Arginine 336 and asparagine 333 of the human cholecystokinin-A receptor binding site interact with the penultimate aspartic acid and the C-terminal amide of cholecystokinin.

21 January 2018

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Evidence for a direct interaction between the penultimate aspartic acid of cholecystokinin and histidine 207, located in the second extracellular loop of the cholecystokinin B receptor

21 January 2018

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Direct identification of a second distinct site of contact between cholecystokinin and its receptor

21 January 2018

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Direct identification of a distinct site of interaction between the carboxyl-terminal residue of cholecystokinin and the type A cholecystokinin receptor using photoaffinity labeling

21 January 2018

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Direct identification of the agonist binding site in the human brain cholecystokininB receptor

21 January 2018

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Cholecystokinin and gastrin antagonists

21 January 2018

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Second generation "peptoid" CCK-B receptor antagonists: identification and development of N-(adamantyloxycarbonyl)-alpha-methyl-(R)-tryptophan derivative (CI-1015) with an improved pharmacokinetic profile

21 January 2018

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Quinazolinone cholecystokinin-B receptor ligands.

21 January 2018

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Synthesis of phenoxyacetic acid derivatives as highly potent antagonists of gastrin/cholecystokinin-B receptors

21 January 2018

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21 January 2018

The benzodiazepine story

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Synthesis, biological evaluation, and quantitative receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as novel tifluadom-like ligands with high affinity and selectivity for kappa-opioid receptors

21 January 2018

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

21 January 2018

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Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

21 January 2018

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Design and synthesis of potent bradykinin agonists containing a benzothiazepine moiety

21 January 2018

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Design of potent, orally effective, nonpeptidal antagonists of the peptide hormone cholecystokinin

21 January 2018

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Biochemical and pharmacological characterization of an extremely potent and selective nonpeptide cholecystokinin antagonist

21 January 2018

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Benzodiazepine gastrin and brain cholecystokinin receptor ligands: L-365,260.

21 January 2018

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A new potent and selective non-peptide gastrin antagonist and brain cholecystokinin receptor (CCK-B) ligand: L-365,260

21 January 2018

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100 years lock-and-key concept: are peptide keys shaped and guided to their receptors by the target cell membrane?

21 January 2018

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Towards 3D structures of G protein-coupled receptors: a multidisciplinary approach

21 January 2018

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Docking ligands onto binding site representations derived from proteins built by homology modelling.

21 January 2018

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[Synthesis of peptides with gastrinlike activity. Studies on the structure-activity relationship of the natural hormone human little gastrin I]

21 January 2018

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The Action of Formaldehyde upon Cysteine

21 January 2018

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Lipophilic derivatization and its effect on the interaction of cholecystokinin (CCK) nonapeptide with phospholipids

21 January 2018

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Transgenic CCK-B/gastrin receptor mediates murine exocrine pancreatic secretion

21 January 2018

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High molecular mass forms of basic fibroblast growth factor are initiated by alternative CUG codons

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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Minor modifications of a cholecystokinin-B/gastrin receptor non-peptide antagonist confer a broad spectrum of functional properties.

21 January 2018

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Structure-based design of new constrained cyclic agonists of the cholecystokinin CCK-B receptor

21 January 2018

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trans-3-n-propyl-L-proline is a highly favorable, conformationally restricted replacement for methionine in the C-terminal tetrapeptide of cholecystokinin. Stereoselective synthesis of 3-allyl- and 3-n-propyl-L-proline derivatives from 4-hydroxy-L-p

21 January 2018

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Controlled modification of acidity in cholecystokinin B receptor antagonists: N-(1,4-benzodiazepin-3-yl)-N'-[3-(tetrazol-5-ylamino) phenyl]ureas

21 January 2018

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(3R)-N-(1-(tert-butylcarbonylmethyl)-2,3-dihydro-2-oxo-5-(2-pyridyl)-1H-1,4-benzodiazepin-3-yl)-N'-(3-(methylamino)phenyl)urea (YF476): a potent and orally active gastrin/CCK-B antagonist

21 January 2018

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Potent and subtype-selective CCK-B/gastrin receptor antagonists: 2,4-dioxo-1,5-benzodiazepines with a plane of symmetry

21 January 2018

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Novel nonpeptide CCK-B antagonists: design and development of quinazolinone derivatives as potent, selective, and orally active CCK-B antagonists.

21 January 2018

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LUDI: rule-based automatic design of new substituents for enzyme inhibitor leads

21 January 2018

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A single amino acid of the cholecystokinin-B/gastrin receptor determines specificity for non-peptide antagonists

21 January 2018

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Formation of stable vesicles from N- or 3-alkylindoles: possible evidence for tryptophan as a membrane anchor in proteins

21 January 2018

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Brain and gastrointestinal cholecystokinin receptor family: structure and functional expression

21 January 2018

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Synthesis and biological evaluation of a new reversely linked type of dual histamine H2 and gastrin receptor antagonist

21 January 2018

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10.1002/1097-0282(2000)56:2<55::AID-BIP1052>3.0.CO;2-M

21 January 2018

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