Mdm2 Inhibits the Apoptotic Function of p53 Mainly by Targeting It for Degradation (Q58431920)

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10 November 2019

title

Mdm2 inhibits the apoptotic function of p53 mainly by targeting it for degradation (English)

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10 November 2019

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1

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10 November 2019

author name string

J K Hsieh

series ordinal

2

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10 November 2019

X Lu

series ordinal

3

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10 November 2019

language of work or name

English

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publication date

1 November 2000

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Journal of Biological Chemistry

10 November 2019

published in

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10 November 2019

volume

275

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10 November 2019

issue

47

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10 November 2019

page(s)

37296-37302

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p53 mutations in human cancers

10 November 2019

cites work

1 reference

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Germ line p53 mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms

21 January 2018

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Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

21 January 2018

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21 January 2018

p53: puzzle and paradigm

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Wild-type p53 negatively regulates the expression of a microtubule-associated protein

21 January 2018

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Differential induction of transcriptionally active p53 following UV or ionizing radiation: defects in chromosome instability syndromes?

21 January 2018

1 reference

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The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation

21 January 2018

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Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53

21 January 2018

1 reference

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Mdm2 promotes the rapid degradation of p53

21 January 2018

1 reference

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Regulation of p53 stability by Mdm2

21 January 2018

1 reference

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Design of a synthetic Mdm2-binding mini protein that activates the p53 response in vivo.

21 January 2018

1 reference

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Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53

21 January 2018

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Rescue of embryonic lethality in Mdm2-deficient mice by absence of p53

21 January 2018

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Characterization of structural p53 mutants which show selective defects in apoptosis but not cell cycle arrest

21 January 2018

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The requirement for the p53 proline-rich functional domain for mediation of apoptosis is correlated with specific PIG3 gene transactivation and with transcriptional repression

21 January 2018

1 reference

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mdm-2 inhibits the G1 arrest and apoptosis functions of the p53 tumor suppressor protein

21 January 2018

1 reference

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Transcriptional activation by p53 correlates with suppression of growth but not transformation.

21 January 2018

1 reference

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Regulation of the specific DNA binding function of p53

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004359200

E2F1-induced apoptosis requires DNA binding but not transactivation and is inhibited by the retinoblastoma protein through direct interaction

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004359200

Regulation of Mdm2-directed degradation by the C terminus of p53.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004359200

p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004359200

Association of p19(ARF) with Mdm2 inhibits ubiquitin ligase activity of Mdm2 for tumor suppressor p53.

21 January 2018

1 reference

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Wild-type p53 can down-modulate the activity of various promoters

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004359200

Induction of DNA synthesis and apoptosis are separable functions of E2F-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004359200

Transcriptional repression by wild-type p53 utilizes histone deacetylases, mediated by interaction with mSin3a.

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004359200

p53 is a general repressor of RNA polymerase III transcription

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004359200

RB regulates the stability and the apoptotic function of p53 via MDM2

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.M004359200

21 January 2018

Identifiers

DOI

10.1074/JBC.M004359200

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10980197%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

1 reference