Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: A pharmacodynamic interaction? (Q58449801)

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15 January 2020

title

Lacosamide neurotoxicity associated with concomitant use of sodium channel-blocking antiepileptic drugs: a pharmacodynamic interaction? (English)

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15 January 2020

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1

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15 January 2020

Ley Sander

series ordinal

3

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author name string

Philip N Patsalos

series ordinal

2

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Sanjay M Sisodiya

series ordinal

4

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publication date

5 November 2010

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15 January 2020

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volume

20

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issue

1

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page(s)

20-23

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Adjunctive lacosamide for partial-onset seizures: Efficacy and safety results from a randomized controlled trial

15 January 2020

cites work

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Lacosamide as adjunctive therapy for partial-onset seizures: a randomized controlled trial

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Efficacy and safety of oral lacosamide as adjunctive therapy in adults with partial-onset seizures

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Drug interactions involving the new second- and third-generation antiepileptic drugs

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No pharmacokinetic interaction between lacosamide and carbamazepine in healthy volunteers

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The investigational anticonvulsant lacosamide selectively enhances slow inactivation of voltage-gated sodium channels.

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Lacosamide: a review of preclinical properties.

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In silico docking and electrophysiological characterization of lacosamide binding sites on collapsin response mediator protein-2 identifies a pocket important in modulating sodium channel slow inactivation

7 January 2021

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Six months of postmarketing experience with adjunctive lacosamide in patients with pharmacoresistant focal epilepsy at a tertiary epilepsy center in Germany

7 January 2021

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A high-performance liquid chromatography assay to monitor the new antiepileptic drug lacosamide in patients with epilepsy

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Reappraisal of polytherapy in epilepsy: a critical review of drug load and adverse effects

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Genetic predictors of the maximum doses patients receive during clinical use of the anti-epileptic drugs carbamazepine and phenytoin

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Seeking a mechanism of action for the novel anticonvulsant lacosamide.

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Molecular motions of the outer ring of charge of the sodium channel: do they couple to slow inactivation?

7 January 2021

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Carbamazepine interacts with a slow inactivation state of NaV1.8-like sodium channels

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Antiepileptic drugs--best practice guidelines for therapeutic drug monitoring: a position paper by the subcommission on therapeutic drug monitoring, ILAE Commission on Therapeutic Strategies

7 January 2021

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10.1016/J.YEBEH.2010.10.002

7 January 2021

Identifiers

DOI

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15 January 2020

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