Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide (Q58483640)

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4 November 2019

title

Role of human liver microsomal CYP3A4 and CYP2B6 in catalyzing N-dechloroethylation of cyclophosphamide and ifosfamide (English)

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4 November 2019

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3

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4 November 2019

author name string

Z Huang

series ordinal

1

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4 November 2019

P Roy

series ordinal

2

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4 November 2019

language of work or name

English

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publication date

1 April 2000

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4 November 2019

published in

Biochemical Pharmacology

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4 November 2019

volume

59

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4 November 2019

issue

8

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4 November 2019

page(s)

961-972

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Ifosfamide/mesna. A review of its antineoplastic activity, pharmacokinetic properties and therapeutic efficacy in cancer

4 November 2019

cites work

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Ifosfamide metabolite chloroacetaldehyde causes renal dysfunction in vivo

7 January 2021

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Ifosfamide metabolite chloroacetaldehyde causes Fanconi syndrome in the perfused rat kidney

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Ifosfamide-induced central nervous system toxicity

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Fluorometric determination of acrolein and related compounds with m-aminophenol

7 January 2021

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High-performance liquid chromatographic determination of acrolein as a marker for cyclophosphamide bioactivation in human liver microsomes

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Determination of 4-hydroxyifosfamide in biological matrices by high-performance liquid chromatography.

7 January 2021

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Analysis of 4-hydroxycyclophosphamide in human blood

7 January 2021

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Identification of the polymorphically expressed CYP2C19 and the wild-type CYP2C9-ILE359 allele as low-Km catalysts of cyclophosphamide and ifosfamide activation.

7 January 2021

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Activation of the anti-cancer drug ifosphamide by rat liver microsomal P450 enzymes

7 January 2021

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Gas chromatographic determination of 2- and 3-dechloroethylifosfamide in plasma and urine

7 January 2021

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Derivatization-liquid chromatographic assay of chloroacetaldehyde in biological samples

7 January 2021

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Determination of chloroacetaldehyde, a metabolite of oxazaphosphorine cytostatic drugs, in plasma

7 January 2021

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Identification of the major human hepatic cytochrome P450 involved in activation and N-dechloroethylation of ifosfamide

7 January 2021

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High-Performance Liquid Chromatographic–Fluorescent Method to Determine Chloroacetaldehyde, a Neurotoxic Metabolite of the Anticancer Drug Ifosfamide, in Plasma and in Liver Microsomal Incubations

7 January 2021

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Inhibitory monoclonal antibody to human cytochrome P450 2B6.

7 January 2021

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Comparative pharmacokinetics of ifosfamide, 4-hydroxyifosfamide, chloroacetaldehyde, and 2- and 3-dechloroethylifosfamide in patients on fractionated intravenous ifosfamide therapy

7 January 2021

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Characterization of the cytochrome P450 involved in side-chain oxidation of cyclophosphamide in humans

7 January 2021

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Stereoselective pharmacokinetics of ifosfamide and its 2- and 3-N-dechloroethylated metabolites in female cancer patients

7 January 2021

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Metabolism and pharmacokinetics of oral and intravenous ifosfamide

7 January 2021

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Differential in vitro hepatic and intestinal metabolism of ifosfamide in the rat

7 January 2021

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10.1016/S0006-2952(99)00410-4

7 January 2021

Identifiers

DOI

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4 November 2019

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