STAT5b Down-regulates Peroxisome Proliferator-activated Receptor α Transcription by Inhibition of Ligand-independent Activation Function Region-1trans-Activation Domain (Q58483661)

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scientific article published in Journal of Biological Chemistry

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English	STAT5b Down-regulates Peroxisome Proliferator-activated Receptor α Transcription by Inhibition of Ligand-independent Activation Function Region-1trans-Activation Domain	scientific article published in Journal of Biological Chemistry

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scholarly article

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Europe PubMed Central

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10514468%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

STAT5b down-regulates peroxisome proliferator-activated receptor alpha transcription by inhibition of ligand-independent activation function region-1 trans-activation domain (English)

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10514468%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

David J. Waxman

2

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10514468%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

author name string

Y C Zhou

1

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31 October 2019

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1 October 1999

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31 October 2019

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9

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Journal of Biological Chemistry

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31 October 2019

274

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31 October 2019

42

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31 October 2019

29874-29882

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31 October 2019

STATs and gene regulation

1 reference

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21 January 2018

A sequence of the CIS gene promoter interacts preferentially with two associated STAT5A dimers: a distinct biochemical difference between STAT5A and STAT5B.

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Stat5a is mandatory for adult mammary gland development and lactogenesis.

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Distinctive roles of STAT5a and STAT5b in sexual dimorphism of hepatic P450 gene expression. Impact of STAT5a gene disruption.

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Requirement of STAT5b for sexual dimorphism of body growth rates and liver gene expression

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The nuclear receptor superfamily: the second decade

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Molecular mechanisms of action of steroid/thyroid receptor superfamily members

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The peroxisome proliferator activated receptors (PPARS) and their effects on lipid metabolism and adipocyte differentiation

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Hypolipidemic drugs, polyunsaturated fatty acids, and eicosanoids are ligands for peroxisome proliferator-activated receptors alpha and delta

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Structural requirements and cell-type specificity for ligand activation of peroxisome proliferator-activated receptors

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Mechanism of action of the nongenotoxic peroxisome proliferators: role of the peroxisome proliferator-activator receptor alpha.

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The peroxisome proliferator-activated receptors at the cross-road of diet and hormonal signalling

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Targeted disruption of the alpha isoform of the peroxisome proliferator-activated receptor gene in mice results in abolishment of the pleiotropic effects of peroxisome proliferators

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21 January 2018

Growth-hormone-receptor and cytokine-receptor-family signaling

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Cross-talk between janus kinase-signal transducer and activator of transcription (JAK-STAT) and peroxisome proliferator-activated receptor-alpha (PPARalpha) signaling pathways. Growth hormone inhibition of pparalpha transcriptional activity mediated

1 reference

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21 January 2018

Characterization of Stat5a and Stat5b homodimers and heterodimers and their association with the glucocortiocoid receptor in mammary cells

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21 January 2018

Functional interactions between Stat5 and the glucocorticoid receptor

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21 January 2018

Growth hormone preferentially induces the rapid, transient expression of SOCS-3, a novel inhibitor of cytokine receptor signaling

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21 January 2018

A new protein containing an SH2 domain that inhibits JAK kinases

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21 January 2018

Structure and function of a new STAT-induced STAT inhibitor

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21 January 2018

A family of cytokine-inducible inhibitors of signalling

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21 January 2018

Regulation of the transcriptional activity of the peroxisome proliferator-activated receptor alpha by phosphorylation of a ligand-independent trans-activating domain

1 reference

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21 January 2018

Activity of the carbamyl phosphate synthetase I promoter in liver nuclear extracts is dependent on a cis-acting C/EBP recognition element

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21 January 2018

An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor gamma (PPAR gamma)

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21 January 2018

Identification of a new member of the steroid hormone receptor superfamily that is activated by a peroxisome proliferator and fatty acids

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21 January 2018

Characterization of three RXR genes that mediate the action of 9-cis retinoic acid

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A novel ligand for an SH3 domain of the adaptor protein Nck bears an SH2 domain and nuclear signaling motifs

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21 January 2018

Identification and characterization of a constitutively active STAT5 mutant that promotes cell proliferation

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21 January 2018

Regulation of the rat liver sodium-dependent bile acid cotransporter gene by prolactin. Mediation of transcriptional activation by Stat5.

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21 January 2018

A unified nomenclature system for the nuclear receptor superfamily

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Hormone-dependent coactivator binding to a hydrophobic cleft on nuclear receptors

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Coactivation and corepression in transcriptional regulation by steroid/nuclear hormone receptors.

1 reference

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Interdomain communication regulating ligand binding by PPAR-gamma

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p300 interacts with the N- and C-terminal part of PPARgamma2 in a ligand-independent and -dependent manner, respectively

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p300 functions as a coactivator for the peroxisome proliferator-activated receptor alpha

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p300/CREB-binding protein enhances the prolactin-mediated transcriptional induction through direct interaction with the transactivation domain of Stat5, but does not participate in the Stat5-mediated suppression of the glucocorticoid response

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Convergence of 9-cis retinoic acid and peroxisome proliferator signalling pathways through heterodimer formation of their receptors

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Mutations in the conserved C-terminal sequence in thyroid hormone receptor dissociate hormone-dependent activation from interference with AP-1 activity.

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Peroxisome proliferator-activated receptor mediates cross-talk with thyroid hormone receptor by competition for retinoid X receptor. Possible role of a leucine zipper-like heptad repeat.

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Proteasomes regulate erythropoietin receptor and signal transducer and activator of transcription 5 (STAT5) activation. Possible involvement of the ubiquitinated Cis protein

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The steroid receptor coactivator-1 contains multiple receptor interacting and activation domains that cooperatively enhance the activation function 1 (AF1) and AF2 domains of steroid receptors.

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Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling

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Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha

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Nuclear integration of JAK/STAT and Ras/AP-1 signaling by CBP and p300.

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Identifiers

10.1074/JBC.274.42.29874

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10514468%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10514468%20AND%20SRC:MED&resulttype=core&format=json

31 October 2019

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