Loss of enzymes in the bile acid synthesis pathway explains differences in bile composition among mammals (Q58616313)

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1 May 2020

title

Loss of Enzymes in the Bile Acid Synthesis Pathway Explains Differences in Bile Composition among Mammals (English)

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1

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1 May 2020

author name string

Michael Hiller

series ordinal

2

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1 May 2020

language of work or name

English

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publication date

1 December 2018

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Genome Biology and Evolution

1 May 2020

published in

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1 May 2020

volume

10

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1 May 2020

issue

12

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1 May 2020

page(s)

3211-3217

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Creative Commons Attribution-NonCommercial 4.0 International

1 May 2020

copyright license

start time

2 November 2018

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April 2022 Public Data File from Crossref

copyright status

copyrighted

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cites work

Bile salts of the West Indian manatee, Trichechus manatus latirostris: novel bile alcohol sulfates and absence of bile acids.

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12 December 2020

Disruption of cholesterol 7alpha-hydroxylase gene in mice. I. Postnatal lethality reversed by bile acid and vitamin supplementation.

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Defective peroxisomal catabolism of branched fatty acyl coenzyme A in mice lacking the sterol carrier protein-2/sterol carrier protein-x gene function

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Markedly reduced bile acid synthesis but maintained levels of cholesterol and vitamin D metabolites in mice with disrupted sterol 27-hydroxylase gene.

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Structure and chromosomal assignment of the sterol 12alpha-hydroxylase gene (CYP8B1) in human and mouse: eukaryotic cytochrome P-450 gene devoid of introns

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Mutations in the gene encoding peroxisomal alpha-methylacyl-CoA racemase cause adult-onset sensory motor neuropathy

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Inactivation of the peroxisomal multifunctional protein-2 in mice impedes the degradation of not only 2-methyl-branched fatty acids and bile acid intermediates but also of very long chain fatty acids

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12 December 2020

Human cholesterol 7alpha-hydroxylase (CYP7A1) deficiency has a hypercholesterolemic phenotype

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12 December 2020

Cholic acid mediates negative feedback regulation of bile acid synthesis in mice

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12 December 2020

Liver disease caused by failure to racemize trihydroxycholestanoic acid: gene mutation and effect of bile acid therapy

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12 December 2020

The enzymes, regulation, and genetics of bile acid synthesis

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12 December 2020

Molecular genetics of 3beta-hydroxy-Delta5-C27-steroid oxidoreductase deficiency in 16 patients with loss of bile acid synthesis and liver disease

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12 December 2020

Complex inheritance of familial hypercholanemia with associated mutations in TJP2 and BAAT.

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12 December 2020

A very long-chain acyl-CoA synthetase-deficient mouse and its relevance to X-linked adrenoleukodystrophy

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Mutations in SRD5B1 (AKR1D1), the gene encoding delta(4)-3-oxosteroid 5beta-reductase, in hepatitis and liver failure in infancy.

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12 December 2020

A mouse model for alpha-methylacyl-CoA racemase deficiency: adjustment of bile acid synthesis and intolerance to dietary methyl-branched lipids

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SRD5B1 (AKR1D1) gene analysis in delta(4)-3-oxosteroid 5beta-reductase deficiency: evidence for primary genetic defect

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Mutational spectrum of D-bifunctional protein deficiency and structure-based genotype-phenotype analysis

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Mice deleted for fatty acid transport protein 5 have defective bile acid conjugation and are protected from obesity

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12 December 2020

Mutations in the gene encoding peroxisomal sterol carrier protein X (SCPx) cause leukencephalopathy with dystonia and motor neuropathy

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12 December 2020

Effect of SCP-x gene ablation on branched-chain fatty acid metabolism.

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12 December 2020

Analysis of HSD3B7 knockout mice reveals that a 3alpha-hydroxyl stereochemistry is required for bile acid function

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12 December 2020

Silencing of hepatic fatty acid transporter protein 5 in vivo reverses diet-induced non-alcoholic fatty liver disease and improves hyperglycemia

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12 December 2020

Bile salts of vertebrates: structural variation and possible evolutionary significance

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12 December 2020

Diversity of bile salts in fish and amphibians: evolution of a complex biochemical pathway

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12 December 2020

Evolutionary diversity of bile salts in reptiles and mammals, including analysis of ancient human and extinct giant ground sloth coprolites

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12 December 2020

FATP2 is a hepatic fatty acid transporter and peroxisomal very long-chain acyl-CoA synthetase

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12 December 2020

AKR1C4 gene variant associated with low euthymic serum progesterone and a history of mood irritability in males with bipolar disorder.

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12 December 2020

Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency

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12 December 2020

Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation

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12 December 2020

Recurrent gene loss correlates with the evolution of stomach phenotypes in gnathostome history.

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12 December 2020

Loss of Cyp8b1 improves glucose homeostasis by increasing GLP-1.

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12 December 2020

Evidence for a single loss of mineralized teeth in the common avian ancestor

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RELAX: detecting relaxed selection in a phylogenetic framework

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12 December 2020

Coding exon-structure aware realigner (CESAR) utilizes genome alignments for accurate comparative gene annotation

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12 December 2020

Evolution by gene loss.

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12 December 2020

ACOX2 deficiency: A disorder of bile acid synthesis with transaminase elevation, liver fibrosis, ataxia, and cognitive impairment

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12 December 2020

ACOX2 deficiency: An inborn error of bile acid synthesis identified in an adolescent with persistent hypertransaminasemia

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12 December 2020

Increased alignment sensitivity improves the usage of genome alignments for comparative gene annotation.

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Inactivation of thermogenic UCP1 as a historical contingency in multiple placental mammal clades

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12 December 2020

CESAR 2.0 substantially improves speed and accuracy of comparative gene annotation.

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12 December 2020

The UCSC Genome Browser database: 2018 update

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12 December 2020

Transition to an Aquatic Habitat Permitted the Repeated Loss of the Pleiotropic KLK8 Gene in Mammals.

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12 December 2020

A novel case of ACOX2 deficiency leads to recognition of a third human peroxisomal acyl-CoA oxidase

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12 December 2020

A genomics approach reveals insights into the importance of gene losses for mammalian adaptations.

1 reference

12 December 2020

Chitinase genes (CHIAs) provide genomic footprints of a post-Cretaceous dietary radiation in placental mammals.

1 reference

12 December 2020

Loss of RXFP2 and INSL3 genes in Afrotheria shows that testicular descent is the ancestral condition in placental mammals.

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12 December 2020

Diagnosis, treatment, and clinical outcomes in 43 cases with cerebrotendinous xanthomatosis

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12 December 2020

Ancient convergent losses of Paraoxonase 1 yield potential risks for modern marine mammals

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12 December 2020

Recurrent loss of HMGCS2 shows that ketogenesis is not essential for the evolution of large mammalian brains

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12 December 2020

Identifiers

DOI

10.1093/GBE/EVY243

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30388264%20AND%20SRC:MED&resulttype=core&format=json

1 May 2020

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1 May 2020

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