Altered acetylation in polyglutamine disease: an opportunity for therapeutic intervention? (Q58623102)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:12067622%20AND%20SRC:MED&resulttype=core&format=json

10 November 2019

title

Altered acetylation in polyglutamine disease: an opportunity for therapeutic intervention? (English)

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10 November 2019

1

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10 November 2019

author name string

Kenneth H Fischbeck

series ordinal

2

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10 November 2019

publication date

1 May 2002

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Trends in Molecular Medicine

10 November 2019

published in

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10 November 2019

volume

8

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10 November 2019

issue

5

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10 November 2019

page(s)

195-197

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Huntington's disease: the challenge for cell biologists

10 November 2019

cites work

1 reference

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Ataxin-1 nuclear localization and aggregation: role in polyglutamine-induced disease in SCA1 transgenic mice

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7 January 2021

Huntingtin acts in the nucleus to induce apoptosis but death does not correlate with the formation of intranuclear inclusions.

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7 January 2021

CREB-binding protein sequestration by expanded polyglutamine

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The Huntington's disease protein interacts with p53 and CREB-binding protein and represses transcription

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Interference by huntingtin and atrophin-1 with cbp-mediated transcription leading to cellular toxicity

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Transcriptional dysregulation in Huntington's disease

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Decreased expression of striatal signaling genes in a mouse model of Huntington's disease

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Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization

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Identification of genes that modify ataxin-1-induced neurodegeneration.

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Altered transcription in yeast expressing expanded polyglutamine

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Expanded polyglutamine protein forms nuclear inclusions and causes neural degeneration in Drosophila

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7 January 2021

Chaperone suppression of aggregation and altered subcellular proteasome localization imply protein misfolding in SCA1.

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7 January 2021

Genetic suppression of polyglutamine toxicity in Drosophila

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7 January 2021

Signaling to chromatin through histone modifications

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7 January 2021

Structure and function of histone acetyltransferases

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7 January 2021

Histone deacetylases: silencers for hire.

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7 January 2021

Histone acetylation and disease

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7 January 2021

Histone deacetylase inhibitors: inducers of differentiation or apoptosis of transformed cells

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7 January 2021

Histone deacetylase inhibitors arrest polyglutamine-dependent neurodegeneration in Drosophila

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7 January 2021

Histone deacetylase inhibitors reduce polyglutamine toxicity

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7 January 2021

10.1016/S1471-4914(02)02332-8

Identifiers

DOI

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10 November 2019

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