Mutations in the Double-stranded RNA-activated Protein Kinase Insert Region That Uncouple Catalysis from eIF2α Binding (Q58666362)

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11 November 2019

title

Mutations in the double-stranded RNA-activated protein kinase insert region that uncouple catalysis from eIF2alpha binding (English)

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11 November 2019

2

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11 November 2019

author name string

R Cai

series ordinal

1

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11 November 2019

language of work or name

English

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publication date

1 May 1998

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Journal of Biological Chemistry

11 November 2019

published in

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11 November 2019

volume

273

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11 November 2019

issue

18

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11 November 2019

page(s)

11274-11280

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Translational control in mammalian cells

11 November 2019

cites work

1 reference

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eIF-2 kinases: regulators of general and gene-specific translation initiation

21 January 2018

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Functional characterization of the RNA-binding domain and motif of the double-stranded RNA-dependent protein kinase DAI (PKR).

21 January 2018

1 reference

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Phosphorylation of initiation factor elF-2 and the control of reticulocyte protein synthesis

21 January 2018

1 reference

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Purification and partial characterization of a cellular inhibitor of the interferon-induced protein kinase of Mr 68,000 from influenza virus-infected cells

21 January 2018

1 reference

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The phosphorylation state of eucaryotic initiation factor 2 alters translational efficiency of specific mRNAs

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.11274

Molecular cloning and characterization of the human double-stranded RNA-activated protein kinase induced by interferon

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.11274

A conserved double-stranded RNA-binding domain

21 January 2018

1 reference

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Mechanism of interferon action motif I of the interferon-induced, RNA-dependent protein kinase (PKR) is sufficient to mediate RNA-binding activity

21 January 2018

1 reference

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Structural requirements for double-stranded RNA binding, dimerization, and activation of the human eIF-2 alpha kinase DAI in Saccharomyces cerevisiae

21 January 2018

1 reference

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Two functionally distinct RNA-binding motifs in the regulatory domain of the protein kinase DAI

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.11274

Functional expression and RNA binding analysis of the interferon-induced, double-stranded RNA-activated, 68,000-Mr protein kinase in a cell-free system

21 January 2018

1 reference

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Malignant transformation by a mutant of the IFN-inducible dsRNA-dependent protein kinase

21 January 2018

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Mutational analysis of the double-stranded RNA (dsRNA) binding domain of the dsRNA-activated protein kinase, PKR.

21 January 2018

1 reference

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Specific mutations near the amino terminus of double-stranded RNA-dependent protein kinase (PKR) differentially affect its double-stranded RNA binding and dimerization properties

21 January 2018

1 reference

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Monoclonal antibodies to an interferon-induced Mr 68,000 protein and their use for the detection of double-stranded RNA-dependent protein kinase in human cells

21 January 2018

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Identification of double-stranded RNA-binding domains in the interferon-induced double-stranded RNA-activated p68 kinase

21 January 2018

1 reference

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Yeast translation initiation suppressor sui2 encodes the alpha subunit of eukaryotic initiation factor 2 and shares sequence identity with the human alpha subunit.

21 January 2018

1 reference

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Double-stranded (ds) RNA binding and not dimerization correlates with the activation of the dsRNA-dependent protein kinase (PKR).

21 January 2018

1 reference

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Mechanism of interferon action: autoregulation of RNA-dependent P1/eIF-2 alpha protein kinase (PKR) expression in transfected mammalian cells

21 January 2018

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Mammalian eukaryotic initiation factor 2 alpha kinases functionally substitute for GCN2 protein kinase in the GCN4 translational control mechanism of yeast

21 January 2018

1 reference

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Mutations activating the yeast eIF-2 alpha kinase GCN2: isolation of alleles altering the domain related to histidyl-tRNA synthetases

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.11274

Phosphorylation of initiation factor 2 alpha by protein kinase GCN2 mediates gene-specific translational control of GCN4 in yeast

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.11274

Structure of a peptide inhibitor bound to the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.11274

High-efficiency transformation of yeast by electroporation

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.11274

Functional expression and characterization of the interferon-induced double-stranded RNA activated P68 protein kinase from Escherichia coli

21 January 2018

1 reference

https://api.crossref.org/works/10.1074%2FJBC.273.18.11274

21 January 2018

Identifiers

DOI

10.1074/JBC.273.18.11274

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9556619%20AND%20SRC:MED&resulttype=core&format=json

11 November 2019

1 reference