Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics (Q58842619)

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5 December 2019

title

Protein farnesyltransferase from Trypanosoma brucei. A heterodimer of 61- and 65-kda subunits as a new target for antiparasite therapeutics (English)

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5 December 2019

Trypanosoma brucei

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K Yokoyama

1

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5 December 2019

P Trobridge

2

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5 December 2019

F S Buckner

3

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5 December 2019

W C Van Voorhis

4

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5 December 2019

K D Stuart

5

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5 December 2019

M H Gelb

6

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5 December 2019

language of work or name

English

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publication date

1 October 1998

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Journal of Biological Chemistry

5 December 2019

published in

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5 December 2019

volume

273

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5 December 2019

issue

41

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5 December 2019

page(s)

26497-26505

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Identification of geranylgeranyl-modified proteins in HeLa cells

5 December 2019

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The hepatitis delta virus large antigen is farnesylated both in vitro and in animal cells

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Protein prenylation: a mediator of protein-protein interactions

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Protein farnesyltransferase and geranylgeranyltransferase share a common alpha subunit

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Protein geranylgeranyltransferase of Saccharomyces cerevisiae is specific for Cys-Xaa-Xaa-Leu motif proteins and requires the CDC43 gene product but not the DPR1 gene product

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Purification of component A of Rab geranylgeranyl transferase: possible identity with the choroideremia gene product

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cDNA cloning of component A of Rab geranylgeranyl transferase and demonstration of its role as a Rab escort protein

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Benzodiazepine peptidomimetics: potent inhibitors of Ras farnesylation in animal cells

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Selective inhibition of ras-dependent transformation by a farnesyltransferase inhibitor

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Resistance of K-RasBV12 proteins to farnesyltransferase inhibitors in Rat1 cells

21 January 2018

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Both farnesyltransferase and geranylgeranyltransferase I inhibitors are required for inhibition of oncogenic K-Ras prenylation but each alone is sufficient to suppress human tumor growth in nude mouse xenografts

21 January 2018

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K- and N-Ras are geranylgeranylated in cells treated with farnesyl protein transferase inhibitors

21 January 2018

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The geranylgeranyltransferase-I inhibitor GGTI-298 arrests human tumor cells in G0/G1 and induces p21(WAF1/CIP1/SDI1) in a p53-independent manner

21 January 2018

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Newly synthesized Rho A, not Ras, is isoprenylated and translocated to membranes coincident with progression of the G1 to S phase of growth-stimulated rat FRTL-5 cells

21 January 2018

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Isoprenylation of proteins in the protozoan Giardia lamblia

21 January 2018

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Characterisation of protein isoprenylation in procyclic form Trypanosoma brucei

21 January 2018

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Prenylation of proteins in Trypanosoma brucei

21 January 2018

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Characterization of mevalonate-labeled lipids isolated from parasite proteins in Schistosoma mansoni

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Evidence for the existence of an Ns-type regulatory protein in Trypanosoma cruzi membranes

21 January 2018

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Trypanosoma brucei: Characterization of a Life Cycle Stage-Specific G-Protein

21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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21 January 2018

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2-substituted piperazines as constrained amino acids. Application to the synthesis of potent, non carboxylic acid inhibitors of farnesyltransferase

21 January 2018

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Novel tricyclic inhibitors of farnesyl protein transferase. Biochemical characterization and inhibition of Ras modification in transfected Cos cells

21 January 2018

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Crystal structure of protein farnesyltransferase at 2.25 angstrom resolution

21 January 2018

1 reference

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Platelet-derived growth factor receptor tyrosine phosphorylation requires protein geranylgeranylation but not farnesylation

21 January 2018

1 reference

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21 January 2018

Identifiers

DOI

10.1074/JBC.273.41.26497

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9756885%20AND%20SRC:MED&resulttype=core&format=json

5 December 2019

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