Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase (Q58846994)

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2 November 2019

title

Nitrofuran drugs as common subversive substrates of Trypanosoma cruzi lipoamide dehydrogenase and trypanothione reductase (English)

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2 November 2019

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K Blumenstiel

1

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2 November 2019

R Schöneck

2

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2 November 2019

V Yardley

3

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2 November 2019

S L Croft

4

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2 November 2019

R L Krauth-Siegel

5

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2 November 2019

language of work or name

English

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publication date

1 December 1999

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2 November 2019

published in

Biochemical Pharmacology

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2 November 2019

volume

58

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2 November 2019

issue

11

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2 November 2019

page(s)

1791-1799

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Trypanothione: a novel bis(glutathionyl)spermidine cofactor for glutathione reductase in trypanosomatids

2 November 2019

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Purification and characterization of trypanothione reductase from Crithidia fasciculata, a newly discovered member of the family of disulfide-containing flavoprotein reductases

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Trypanothione reductase from Trypanosoma cruzi. Purification and characterization of the crystalline enzyme.

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Evidence for the co-existence of glutathione reductase and trypanothione reductase in the non-trypanosomatid Euglenozoa: Euglena gracilis Z

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The identity of diaphorase and lipoyl dehydrogenase

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The mechanism of the quinone reductase reaction of pig heart lipoamide dehydrogenase

7 January 2021

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Catalysis of nitrofuran redox-cycling and superoxide anion production by heart lipoamide dehydrogenase

7 January 2021

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Disulfide-Reductase Inhibitors as Chemotherapeutic Agents: The Design of Drugs for Trypanosomiasis and Malaria

7 January 2021

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Purification and characterization of lipoamide dehydrogenase from Trypanosoma cruzi

7 January 2021

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Cloning, sequencing, overproduction and purification of trypanothione reductase from Trypanosoma cruzi

7 January 2021

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Cloning, sequencing and functional expression of dihydrolipoamide dehydrogenase from the human pathogen Trypanosoma cruzi

7 January 2021

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Metabolism and functions of trypanothione in the Kinetoplastida

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Generation of superoxide anion and hydrogen peroxide induced by nifurtimox in Trypanosoma cruzi

7 January 2021

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Sensitivity of parasites to free radical damage by antiparasitic drugs

7 January 2021

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Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs

7 January 2021

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Trypanothione reductase from Trypanosoma cruzi. Catalytic properties of the enzyme and inhibition studies with trypanocidal compounds

7 January 2021

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Crystal structure of the Trypanosoma cruzi trypanothione reductase.mepacrine complex

7 January 2021

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"Subversive" substrates for the enzyme trypanothione disulfide reductase: alternative approach to chemotherapy of Chagas disease

7 January 2021

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Chinifur, a selective inhibitor and "subversive substrate" for Trypanosoma congolense trypanothione reductase

7 January 2021

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Crystallization and preliminary crystallographic analysis of trypanothione reductase from Trypanosoma cruzi , the causative agent of Chagas' disease

7 January 2021

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Folding of the four domains and dimerization are impaired by the Gly446-->Glu exchange in human glutathione reductase. Implications for the design of antiparasitic drugs

7 January 2021

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Glutathione Reductase from Human Erythrocytes. Catalytic Properties and Aggregation

7 January 2021

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An in-vitro system for determining the activity of compounds against the intracellular amastigote form of Leishmania donovani

7 January 2021

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A colorimetric assay for trypanosome viability and metabolic function

7 January 2021

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One- and two-electron reduction of quinones by glutathione reductase

7 January 2021

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Mechanism of reduction of quinones by Trypanosoma congolense trypanothione reductase

7 January 2021

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Studies on menadione reductase of bakers' yeast. II. Inhibition of the enzyme activity by NAD and stimulation of that by p-chloromercuribenzoate

7 January 2021

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Formation and reduction of glutathione-protein mixed disulfides during oxidative stress. A study with isolated hepatocytes and menadione (2-methyl-1,4-naphthoquinone)

7 January 2021

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A crystallographic study of the glutathione binding site of glutathione reductase at 0.3-nm resolution

7 January 2021

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Interaction of nitrofurans with glutathione reductase

7 January 2021

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Trypanosoma cruzi: immunolocalization of trypanothione reductase

7 January 2021

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Flavoprotein structure and mechanism. 5. Trypanothione reductase and lipoamide dehydrogenase as targets for a structure-based drug design.

7 January 2021

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inferred from DOI database lookup

7 January 2021

based on heuristic

The activity of plumbagin and other electron carriers against Leishmania donovani and Leishmania mexicana amazonensis.

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inferred from DOI database lookup

7 January 2021

based on heuristic

Identifiers

DOI

10.1016/S0006-2952(99)00264-6

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:10571254%20AND%20SRC:MED&resulttype=core&format=json

2 November 2019

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