Focus on PAINS: false friends in the quest for selective anti-protozoal lead structures from Nature? (Q58856163)

https://api.crossref.org/works/10.1039%2FC5MD00481K

Drug resistance in leishmaniasis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Qinghaosu (artemisinin): an antimalarial drug from China

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Plant antitumor agents. VI. The isolation and structure of taxol, a novel antileukemic and antitumor agent from Taxus brevifolia

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Antileishmanial high-throughput drug screening reveals drug candidates with new scaffolds

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Chemistry: Chemical con artists foil drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Can Invalid Bioactives Undermine Natural Product-Based Drug Discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

New substructure filters for removal of pan assay interference compounds (PAINS) from screening libraries and for their exclusion in bioassays

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Chemical motifs that redox cycle and their associated toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Chemical properties of catechols and their molecular modes of toxic action in cells, from microorganisms to mammals

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Quinone chemistry and toxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Molecular mechanisms of quinone cytotoxicity

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Quantitative structure--antiprotozoal activity relationships of sesquiterpene lactones

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Phytochemicals perturb membranes and promiscuously alter protein function.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Evaluation of fluorescent compound interference in 4 fluorescence polarization assays: 2 kinases, 1 protease, and 1 phosphatase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

A Common Mechanism Underlying Promiscuous Inhibitors from Virtual and High-Throughput Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Screening in a spirit haunted world

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Aggregating behavior of phenolic compounds--a source of false bioassay results?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Drug discovery and human African trypanosomiasis: a disease less neglected?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Coumarins from Galipea panamensis and Their Activity against Leishmania panamensis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Disesquiterpene and sesquiterpene coumarins from Ferula pseudalliacea, and determination of their absolute configurations.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

An unusual dimeric guaianolide with antiprotozoal activity and further sesquiterpene lactones from Eupatoriumperfoliatum

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Naturally Occurring Xanthones: Chemistry and Biology

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

In vivo Antimalarial Activity of α-Mangostin and the New Xanthone δ-Mangostin

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Antiparasitic activity of C-geranyl flavonoids from Mimulus bigelovii

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Antioxidant and antiradical activities of flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Antibacterial activity of pure flavonoids isolated from mosses

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Antitumor activity of some natural flavonoids and synthetic derivatives on various human and murine cancer cell lines

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Inhibition of alpha-glucosidase and alpha-amylase by flavonoids

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Suppression of inducible cyclooxygenase and inducible nitric oxide synthase by apigenin and related flavonoids in mouse macrophages.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Antitrypanosomal and antileishmanial activities of flavonoids and their analogues: in vitro, in vivo, structure-activity relationship, and quantitative structure-activity relationship studies

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Effect of Apigenin on Leishmania amazonensis Is Associated with Reactive Oxygen Species Production Followed by Mitochondrial Dysfunction

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

The leishmanicidal flavonols quercetin and quercitrin target Leishmania (Leishmania) amazonensis arginase

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Chemical constituents and leishmanicidal activity from leaves of Kielmeyera variabilis

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Dietary flavonoids fisetin, luteolin and their derived compounds inhibit arginase, a central enzyme in Leishmania (Leishmania) amazonensis infection.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Licochalcone A, a novel antiparasitic agent with potent activity against human pathogenic protozoan species of Leishmania

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

The antileishmanial activity of novel oxygenated chalcones and their mechanism of action

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Licochalcone A, a new antimalarial agent, inhibits in vitro growth of the human malaria parasite Plasmodium falciparum and protects mice from P. yoelii infection

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Potent antimalarial activity of newly synthesized substituted chalcone analogs in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

In vitro antimycobacterial and antilegionella activity of licochalcone A from Chinese licorice roots

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Synthesis and insight into the structure-activity relationships of chalcones as antimalarial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

The antiparasitic compound licochalcone a is a potent echinocytogenic agent that modifies the erythrocyte membrane in the concentration range where antiplasmodial activity is observed.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Synthesis, structure-activity relationships, and biological studies of chromenochalcones as potential antileishmanial agents

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Synthesis and biological evaluation of chalcones as potential antileishmanial agents.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

The chemistry of curcumin: from extraction to therapeutic agent

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Curcumin as "Curecumin": from kitchen to clinic.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

The multifaceted role of curcumin in cancer prevention and treatment.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Curcumin content of turmeric and curry powders

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Determining the effects of lipophilic drugs on membrane structure by solid-state NMR spectroscopy: the case of the antioxidant curcumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Curcumin-glutathione interactions and the role of human glutathione S-transferase P1-1.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Iron chelation in the biological activity of curcumin.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Reactive oxygen species and imbalance of calcium homeostasis contributes to curcumin induced programmed cell death in Leishmania donovani

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Cytotoxic effect of curcumin on malaria parasite Plasmodium falciparum: inhibition of histone acetylation and generation of reactive oxygen species

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Potent trypanocidal curcumin analogs bearing a monoenone linker motif act on Trypanosoma brucei by forming an adduct with trypanothione

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Leishmanicidal effect of curcumin in vitro

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Curcuminoid analogs with potent activity against Trypanosoma and Leishmania species

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Potential anticancer activity of turmeric (Curcuma longa).

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Curcumin inhibits formation of amyloid beta oligomers and fibrils, binds plaques, and reduces amyloid in vivo

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Six-month randomized, placebo-controlled, double-blind, pilot clinical trial of curcumin in patients with Alzheimer disease

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Oral curcumin for Alzheimer's disease: tolerability and efficacy in a 24-week randomized, double blind, placebo-controlled study

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Studies of curcumin and curcuminoids. XXVII. Cyclodextrin complexation: solubility, chemical and photochemical stability

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Dose escalation of a curcuminoid formulation

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Nanoparticle encapsulation improves oral bioavailability of curcumin by at least 9-fold when compared to curcumin administered with piperine as absorption enhancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Dose-escalation and pharmacokinetic study of nanoparticle curcumin, a potential anticancer agent with improved bioavailability, in healthy human volunteers

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Anti-inflammatory effects of the Nigella sativa seed extract, thymoquinone, in pancreatic cancer cells

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Effects of thymoquinone on antioxidant enzyme activities, lipid peroxidation and DT-diaphorase in different tissues of mice: a possible mechanism of action.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Thymoquinone: a promising anti-cancer drug from natural sources

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Characterization and Stability Evaluation of Thymoquinone Nanoemulsions Prepared by High-Pressure Homogenization

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Thymoquinone in liposomes: a study of loading efficiency and biological activity towards breast cancer.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Stability-indicating ultra-performance liquid chromatography method for the estimation of thymoquinone and its application in biopharmaceutical studies.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

In vitro toxicological properties of thymoquinone

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Reactive oxygen species mediate thymoquinone-induced apoptosis and activate ERK and JNK signaling

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

PAINS: Relevance to Tool Compound Discovery and Fragment-Based Screening

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Screening-based translation of public research encounters painful problems

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Apparent activity in high-throughput screening: origins of compound-dependent assay interference

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Mitigating risk in academic preclinical drug discovery

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Designing screens: how to make your hits a hit.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Exploring the biological promiscuity of high-throughput screening hits through DFT calculations

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Redox cycling compounds generate H2O2 in HTS buffers containing strong reducing reagents--real hits or promiscuous artifacts?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

ALARM NMR: a rapid and robust experimental method to detect reactive false positives in biochemical screens

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

An NMR spectroscopic method to identify and classify thiol-trapping agents: revival of Michael acceptors for drug discovery?

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Potency of Michael reaction acceptors as inducers of enzymes that protect against carcinogenesis depends on their reactivity with sulfhydryl groups

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Covalent modifiers: an orthogonal approach to drug design

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

The resurgence of covalent drugs

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Learning from PAINful lessons

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K

Antileishmanial lead structures from nature: analysis of structure-activity relationships of a compound library derived from caffeic Acid bornyl ester.

21 January 2018

1 reference

https://api.crossref.org/works/10.1039%2FC5MD00481K