The Cholinergic Antagonist Gymnodimine Improves Aβ and Tau Neuropathology in an in Vitro Model of Alzheimer Disease (Q59192562)

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

title

The cholinergic antagonist gymnodimine improves Aβ and tau neuropathology in an in vitro model of Alzheimer disease (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Carmen Vale

2

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Luis M. Botana

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

author name string

Lydia Giménez-Llort

5

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Mercedes R Vieytes

3

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

Frank M Laferla

4

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

publication date

17 June 2011

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

Cellular Physiology and Biochemistry

5 February 2020

published in

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

volume

27

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

issue

6

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

page(s)

783-794

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

Acute toxicity of gymnodimine to mice

5 February 2020

cites work

1 reference

Structural determinants in phycotoxins and AChBP conferring high affinity binding and nicotinic AChR antagonism

21 January 2018

1 reference

Nicotinic acetylcholine receptor signalling: roles in Alzheimer's disease and amyloid neuroprotection.

21 January 2018

1 reference

The cholinergic hypothesis of geriatric memory dysfunction

21 January 2018

1 reference

The cholinergic hypothesis of Alzheimer's disease: a review of progress

21 January 2018

1 reference

Neuronal nicotinic receptors: a perspective on two decades of drug discovery research

21 January 2018

1 reference

Stimulation of alpha4beta2 nicotinic acetylcholine receptors inhibits beta-amyloid toxicity.

21 January 2018

1 reference

Nicotine exacerbates tau phosphorylation and cognitive impairment induced by amyloid-beta 25-35 in rats.

21 January 2018

1 reference

The alpha7 nicotinic acetylcholine receptor-selective antagonist, methyllycaconitine, partially protects against beta-amyloid1-42 toxicity in primary neuron-enriched cultures

21 January 2018

1 reference

Profile for amyloid-beta and tau expression in primary cortical cultures from 3xTg-AD mice

21 January 2018

1 reference

Effects of azaspiracid-1, a potent cytotoxic agent, on primary neuronal cultures. A structure-activity relationship study

21 January 2018

1 reference

Characterization of a chemical anoxia model in cerebellar granule neurons using sodium azide: protection by nifedipine and MK-801.

21 January 2018

1 reference

Beta-amyloid protein increases the vulnerability of cultured cortical neurons to excitotoxic damage

21 January 2018

1 reference

Roles of nicotinic receptors in acetylcholinesterase inhibitor-induced neuroprotection and nicotinic receptor up-regulation

21 January 2018

1 reference

Ca2+ signals and neuronal death in brain ischemia

21 January 2018

1 reference

Calcium and neurodegeneration

21 January 2018

1 reference

Impairment of cholinergic neurotransmission in adult and aged transgenic Tg2576 mouse brain expressing the Swedish mutation of human beta-amyloid precursor protein

21 January 2018

1 reference

Cholinergic dysfunction in a mouse model of Alzheimer disease is reversed by an anti-A beta antibody

21 January 2018

1 reference

Interactions between the amyloid and cholinergic mechanisms in Alzheimer's disease

21 January 2018

1 reference

Muscarinic acetylcholine receptors as CNS drug targets

21 January 2018

1 reference

Differential presynaptic and postsynaptic expression of m1-m4 muscarinic acetylcholine receptors at the perforant pathway/granule cell synapse

21 January 2018

1 reference

Calcium responses to caffeine and muscarinic receptor agonists are altered in traumatically injured neurons

21 January 2018

1 reference

Reduced high-affinity agonist binding at the M(1) muscarinic receptor in Alzheimer's disease brain: differential sensitivity to agonists and divalent cations

21 January 2018

1 reference

Psychosis of Alzheimer's disease is associated with elevated muscarinic M2 binding in the cortex

21 January 2018

1 reference

Impaired coupling of muscarinic M1 receptors to G-proteins in the neocortex is associated with severity of dementia in Alzheimer's disease

21 January 2018

1 reference

Nicotinic receptor agonists and antagonists increase sAPPalpha secretion and decrease Abeta levels in vitro

21 January 2018

1 reference

M1 receptors play a central role in modulating AD-like pathology in transgenic mice

21 January 2018

1 reference

Epitope mapping of mAbs AT8 and Tau5 directed against hyperphosphorylated regions of the human tau protein

21 January 2018

1 reference

Monoclonal antibodies with selective specificity for Alzheimer Tau are directed against phosphatase-sensitive epitopes

21 January 2018

1 reference

Current advances on different kinases involved in tau phosphorylation, and implications in Alzheimer's disease and tauopathies

21 January 2018

1 reference

Distribution of active glycogen synthase kinase 3beta (GSK-3beta) in brains staged for Alzheimer disease neurofibrillary changes

21 January 2018

1 reference

Protective effect of caffeic acid against beta-amyloid-induced neurotoxicity by the inhibition of calcium influx and tau phosphorylation

21 January 2018

1 reference

MAPK recruitment by beta-amyloid in organotypic hippocampal slice cultures depends on physical state and exposure time

21 January 2018

1 reference

Alpha 7 nicotinic acetylcholine receptors mediate beta-amyloid peptide-induced tau protein phosphorylation

21 January 2018

1 reference

Feasibility of gymnodimine and 13-desmethyl C spirolide detection by fluorescence polarization using a receptor-based assay in shellfish matrixes

21 January 2018

1 reference

Dissociating beta-amyloid from alpha 7 nicotinic acetylcholine receptor by a novel therapeutic agent, S 24795, normalizes alpha 7 nicotinic acetylcholine and NMDA receptor function in Alzheimer's disease brain.

21 January 2018

1 reference

beta-Amyloid(1-42) binds to alpha7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology

21 January 2018

1 reference

Amyloid peptide Abeta(1-42) binds selectively and with picomolar affinity to alpha7 nicotinic acetylcholine receptors

21 January 2018

1 reference

Role of GSK-3beta activation and alpha7 nAChRs in Abeta(1-42)-induced tau phosphorylation in PC12 cells

21 January 2018

1 reference

Amyloid beta peptide induces tau phosphorylation and loss of cholinergic neurons in rat primary septal cultures

21 January 2018

1 reference

In vivo pharmacological characterization of a novel selective alpha7 neuronal nicotinic acetylcholine receptor agonist ABT-107: preclinical considerations in Alzheimer's disease

21 January 2018

1 reference

Neuronal nicotinic acetylcholine receptors - targets for the development of drugs to treat cognitive impairment associated with schizophrenia and Alzheimer's disease

21 January 2018

1 reference

SAR and biological evaluation of SEN12333/WAY-317538: Novel alpha 7 nicotinic acetylcholine receptor agonist

21 January 2018

1 reference

Nicotinic acetylcholine receptors as drug targets

21 January 2018

1 reference

21 January 2018

Identifiers

DOI

10.1159/000330086

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:21691095%20AND%20SRC:MED&resulttype=core&format=json

5 February 2020

1 reference