Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients (Q59845387)

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7 January 2020

title

Peripheral metabolism of (R)-[11C]verapamil in epilepsy patients (English)

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3

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Adriaan A Lammertsma

9

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Oliver Langer

12

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author name string

Aiman Abrahim

1

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Gert Luurtsema

2

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Rudolf Karch

4

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Mark Lubberink

5

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Ekaterina Pataraia

6

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Christian Joukhadar

7

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Kurt Kletter

8

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Christoph Baumgartner

10

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Markus Müller

11

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publication date

11 September 2007

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European Journal of Nuclear Medicine and Molecular Imaging

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published in

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volume

35

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issue

1

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page(s)

116-123

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Quantitative assessment of P-glycoprotein function in the rat blood-brain barrier by distribution volume of [11C]verapamil measured with PET.

7 January 2020

cites work

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12 December 2020

Verapamil P-glycoprotein transport across the rat blood-brain barrier: cyclosporine, a concentration inhibition analysis, and comparison with human data

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12 December 2020

Carbon-11-labeled daunorubicin and verapamil for probing P-glycoprotein in tumors with PET.

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(R)- and (S)-[11C]verapamil as PET-tracers for measuring P-glycoprotein function: in vitro and in vivo evaluation.

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A mechanistic approach to antiepileptic drug interactions

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In vivo evaluation of P-glycoprotein function at the blood-brain barrier in nonhuman primates using [11C]verapamil

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Clinically relevant drug interactions with antiepileptic drugs

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Use of verapamil as a potential P-glycoprotein inhibitor in a patient with refractory epilepsy

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Imaging P-glycoprotein at the human blood-brain barrier

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Influence of functional haplotypes in the drug transporter gene ABCB1 on central nervous system drug distribution in humans

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Near-total reduction in verapamil bioavailability by rifampin. Electrocardiographic correlates

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Biochemical, cellular, and pharmacological aspects of the multidrug transporter

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Verapamil potentiates carbamazepine neurotoxicity: a clinically important inhibitory interaction

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12 December 2020

Characterization of the major metabolites of verapamil as substrates and inhibitors of P-glycoprotein

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12 December 2020

Evaluation of (R)-[11C]verapamil as PET tracer of P-glycoprotein function in the blood-brain barrier: kinetics and metabolism in the rat.

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12 December 2020

Blood-brain barrier dysfunction in parkinsonian midbrain in vivo

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12 December 2020

Evaluation of in vivo P-glycoprotein function at the blood-brain barrier among MDR1 gene polymorphisms by using 11C-verapamil.

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12 December 2020

Drug transporters in the epileptic brain

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12 December 2020

Cytochromes of the P450 2C subfamily are the major enzymes involved in the O-demethylation of verapamil in humans

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12 December 2020

In vitro and in vivo drug interactions involving human CYP3A.

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12 December 2020

Pharmacoresistance in epilepsy: a pilot PET study with the P-glycoprotein substrate R-[(11)C]verapamil

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12 December 2020

Treatment of drug resistance in epilepsy: one step at a time

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12 December 2020

Evaluation of tracer kinetic models for quantification of P-glycoprotein function using (R)-[11C]verapamil and PET.

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12 December 2020

Effects of chronic phenobarbital on verapamil disposition in humans

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12 December 2020

Duration and degree of cyclosporin induced P-glycoprotein inhibition in the rat blood-brain barrier can be studied with PET.

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12 December 2020

Verapamil. An updated review of its pharmacodynamic and pharmacokinetic properties, and therapeutic use in hypertension

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12 December 2020

The metabolism of DL-[14C]verapamil in man

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12 December 2020

Imaging P-glycoprotein transport activity at the human blood-brain barrier with positron emission tomography

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12 December 2020

Identification of P450 enzymes involved in metabolism of verapamil in humans

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12 December 2020

Clinically important drug interactions in epilepsy: general features and interactions between antiepileptic drugs

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12 December 2020

Effect of age on functional P-glycoprotein in the blood-brain barrier measured by use of (R)-[(11)C]verapamil and positron emission tomography

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12 December 2020

Complete in vivo reversal of P-glycoprotein pump function in the blood-brain barrier visualized with positron emission tomography

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12 December 2020

Clinically important drug interactions in epilepsy: interactions between antiepileptic drugs and other drugs

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12 December 2020

Calcium-channel blocker verapamil administration in prolonged and refractory status epilepticus

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12 December 2020

10.1007/S00259-007-0556-5

Identifiers

DOI

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7 January 2020

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