Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity (Q60467315)

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6 November 2019

title

Active-site mutagenesis of tetanus neurotoxin implicates TYR-375 and GLU-271 in metalloproteolytic activity (English)

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6 November 2019

1

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6 November 2019

Fiorella Tonello

4

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6 November 2019

author name string

P Caccin

2

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6 November 2019

M Rigoni

3

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6 November 2019

N Bortoletto

5

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6 November 2019

R C Stevens

6

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6 November 2019

C Montecucco

7

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6 November 2019

publication date

1 August 2001

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6 November 2019

number of pages

9

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inferred from page(s)

published in

Toxicon

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6 November 2019

volume

39

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6 November 2019

issue

8

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6 November 2019

page(s)

1151-1159

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Astacins, serralysins, snake venom and matrix metalloproteinases exhibit identical zinc-binding environments (HEXXHXXGXXH and Met-turn) and topologies and should be grouped into a common family, the 'metzincins'

6 November 2019

cites work

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Solid-phase synthesis, conformational analysis and in vitro cleavage of synthetic human synaptobrevin II 1-93 by tetanus toxin L chain

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7 January 2021

Structural studies on the zinc-endopeptidase light chain of tetanus neurotoxin

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The complete nucleotide sequence of tetanus toxin

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Calculation of protein extinction coefficients from amino acid sequence data

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Cocrystal structure of synaptobrevin-II bound to botulinum neurotoxin type B at 2.0 A resolution

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7 January 2021

Contribution of disulfide bonds to stability of the folding intermediate of alpha-lactalbumin

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Sequence homology and structural analysis of the clostridial neurotoxins

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7 January 2021

Crystal structure of botulinum neurotoxin type A and implications for toxicity

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Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

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Secondary structural predictions for the clostridial neurotoxins.

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A single mutation in the recombinant light chain of tetanus toxin abolishes its proteolytic activity and removes the toxicity seen after reconstitution with native heavy chain.

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Probing the mechanistic role of glutamate residue in the zinc-binding motif of type A botulinum neurotoxin light chain

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Structural basis of the action of thermolysin and related zinc peptidases

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Tetanus and botulism neurotoxins: a new group of zinc proteases.

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X-ray Absorption Spectroscopy Study of Zinc Coordination in Tetanus Neurotoxin, Astacin, Alkaline Protease and Thermolysin

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Progress towards the development of new vaccines against whooping cough

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Evolutionary families of metallopeptidases

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Tetanus and botulinum neurotoxins: turning bad guys into good by research

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Tetanus and botulinum-B neurotoxins block neurotransmitter release by proteolytic cleavage of synaptobrevin

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Structural analysis of the catalytic and binding sites of Clostridium botulinum neurotoxin B

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7 January 2021

Recombinant and Truncated Tetanus Neurotoxin Light Chain: Cloning, Expression, Purification, and Proteolytic Activity

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7 January 2021

Metal substitution of tetanus neurotoxin

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7 January 2021

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications

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7 January 2021

Zinc coordination, function, and structure of zinc enzymes and other proteins

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Synaptobrevin/vesicle-associated membrane protein (VAMP) of Aplysia californica: structure and proteolysis by tetanus toxin and botulinal neurotoxins type D and F.

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7 January 2021

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Identifiers

DOI

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6 November 2019

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