Islets of Langerhans from prohormone convertase-2 knockout mice show α-cell hyperplasia and tumorigenesis with elevated α-cell neogenesis (Q60530158)

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Simon R Brocklehurst

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Catherine J Betts

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Sue Bickerton

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Alison L Bigley

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Richard P Jenkins

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Nicky M Whalley

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Derrick Morgan

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David M Smith

International Journal of Experimental Pathology

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language of work or name

English

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publication date

February 2014

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published in

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volume

95

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page(s)

29-48

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issue

1

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cites work

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Benefits and limitations of reducing glucagon action for the treatment of type 2 diabetes

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The ectopic expression of Pax4 in the mouse pancreas converts progenitor cells into alpha and subsequently beta cells

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Glucagon receptor knockout prevents insulin-deficient type 1 diabetes in mice

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Insulin and glucagon regulate pancreatic α-cell proliferation

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Chronic treatment with a glucagon receptor antagonist lowers glucose and moderately raises circulating glucagon and glucagon-like peptide 1 without severe alpha cell hypertrophy in diet-induced obese mice

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Pancreatic neuroendocrine tumors in glucagon receptor-deficient mice

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Liver-derived systemic factors drive β cell hyperplasia in insulin-resistant states.

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Mechanisms of nongenotoxic carcinogenesis and assessment of the human hazard.

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Severe defect in proglucagon processing in islet A-cells of prohormone convertase 2 null mice

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Glycemic control in mice with targeted disruption of the glucagon receptor gene

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Glucagon replacement via micro-osmotic pump corrects hypoglycemia and alpha-cell hyperplasia in prohormone convertase 2 knockout mice

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Lower blood glucose, hyperglucagonemia, and pancreatic alpha cell hyperplasia in glucagon receptor knockout mice

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Abrogation of protein convertase 2 activity results in delayed islet cell differentiation and maturation, increased alpha-cell proliferation, and islet neogenesis.

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Defective prohormone processing and altered pancreatic islet morphology in mice lacking active SPC2.

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Incomplete processing of proinsulin to insulin accompanied by elevation of Des-31,32 proinsulin intermediates in islets of mice lacking active PC2.

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Significance of prohormone convertase 2, PC2, mediated initial cleavage at the proglucagon interdomain site, Lys70-Arg71, to generate glucagon.

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