Phospholipase C zeta 1 (Q6055408)

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mammalian protein found in Homo sapiens

Phospholipase C-zeta-1
Testis-development protein NYD-SP27
PLCZ1
PLC-zeta-1
phosphoinositide phospholipase C-zeta-1
testis-development related NYD-SP27
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1
testicular tissue protein Li 145
PI-phospholipase C zeta 1

Language	Label	Description	Also known as
English	Phospholipase C zeta 1	mammalian protein found in Homo sapiens	Phospholipase C-zeta-1 Testis-development protein NYD-SP27 PLCZ1 PLC-zeta-1 phosphoinositide phospholipase C-zeta-1 testis-development related NYD-SP27 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 testicular tissue protein Li 145 PI-phospholipase C zeta 1

Statements

1 reference

13 November 2019

UniProt protein ID

C2 domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86YW0

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86YW0

PLC-like phosphodiesterase, TIM beta/alpha-barrel domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86YW0

EF-hand domain pair

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86YW0

EF-hand domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

C2 domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphatidylinositol-specific phospholipase C, X domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phospholipase C, phosphatidylinositol-specific, Y domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Phosphoinositide-specific phospholipase C, EF-hand-like domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

phosphoric diester hydrolase activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

calcium ion binding

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

hydrolase activity

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

signal transducer activity

determination method

1 reference

27 February 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

phosphatidylinositol phospholipase C activity

determination method

6 references

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

10 September 2018

Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

10 September 2018

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

phosphatidylinositol-4,5-bisphosphate binding

determination method

1 reference

8 April 2019

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

phosphatidylinositol-5-phosphate binding

determination method

1 reference

8 April 2019

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

phosphatidylinositol-3-phosphate binding

determination method

1 reference

8 April 2019

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

phosphatidylinositol phospholipase C activity

determination method

7 references

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

7 November 2018

Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

7 November 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

7 November 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

7 November 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

7 November 2018

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

7 November 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

phosphatidylinositol-5-phosphate binding

determination method

phosphatidylinositol-3-phosphate binding

determination method

phosphatidylinositol phospholipase C activity

determination method

6 references

8 April 2019

Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

Male infertility-linked point mutation reveals a vital binding role for the C2 domain of sperm PLCζ.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

perinuclear region of cytoplasm

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

determination method

2 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

determination method

1 reference

8 April 2019

Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

biological process

multicellular organism development

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

lipid catabolic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

intracellular signal transduction

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

single fertilization

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

inositol phosphate metabolic process

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

determination method

3 references

8 April 2019

Homozygous mutation of PLCZ1 leads to defective human oocyte activation and infertility that is not rescued by the WW-binding protein PAWP

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

positive regulation of cytosolic calcium ion concentration

determination method

positive regulation of cytosolic calcium ion concentration involved in egg activation

determination method

3 references

10 September 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

10 September 2018

Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

10 September 2018

Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q86YW0&geneProductId=UniProtKB:Q86YW0

determination method

positive regulation of cytosolic calcium ion concentration involved in egg activation

determination method

4 references

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

Functional disparity between human PAWP and PLCζ in the generation of Ca2+ oscillations for oocyte activation

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

inositol trisphosphate biosynthetic process

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q86YW0

determination method

EC enzyme number

3.1.4.11

1 reference

imported from Wikimedia project

Spanish Wikipedia

http://purl.uniprot.org/uniprot/Q86YW0

1 reference

Identifiers.org

Phosphatidylinositol-specific phospholipase C, X domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86YW0

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86YW0

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86YW0

Phosphoinositide-specific phospholipase C, EF-hand-like domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86YW0

Phospholipase C, phosphatidylinositol-specific, Y domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/Q86YW0

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000266505

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000266505

ENSP00000445026

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445026

ENSP00000326397

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000326397

ENSP00000438629

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000438629

ENSP00000438679

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000438679

ENSP00000438826

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000438826

ENSP00000440781

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000440781

ENSP00000443320

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443320

ENSP00000443762

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000443762

ENSP00000444383

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444383

ENSP00000444611

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000444611

ENSP00000445287

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445287

ENSP00000445880

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445880

ENSP00000445889

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000445889

ENSP00000497636

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000497636

Google Knowledge Graph ID

0 references

Sitelinks

Wikipedia(1 entry)

eswiki PLCZ1

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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