Deficient Positive Selection of CD4 T Cells in Mice Displaying Altered Repertoires of MHC Class II–Bound Self-Peptides (Q60641123)

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5 November 2019

title

Deficient positive selection of CD4 T cells in mice displaying altered repertoires of MHC class II-bound self-peptides (English)

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5 November 2019

2

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5 November 2019

author name string

C E Grubin

series ordinal

1

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5 November 2019

P deRoos

series ordinal

3

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5 November 2019

A Y Rudensky

series ordinal

4

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5 November 2019

language of work or name

English

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publication date

1 August 1997

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5 November 2019

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5 November 2019

volume

7

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5 November 2019

issue

2

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5 November 2019

page(s)

197-208

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Peptide contributes to the specificity of positive selection of CD8+ T cells in the thymus

5 November 2019

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Defective major histocompatibility complex class II assembly, transport, peptide acquisition, and CD4+ T cell selection in mice lacking invariant chain expression

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Predominant naturally processed peptides bound to HLA-DR1 are derived from MHC-related molecules and are heterogeneous in size

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Specificity and promiscuity among naturally processed peptides bound to HLA-DR alleles

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The thymic compartment responsible for positive selection of CD4+ T cells

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HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

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A study of complexes of class II invariant chain peptide: major histocompatibility complex class II molecules using a new complex-specific monoclonal antibody.

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The invariant chain is required for intracellular transport and function of major histocompatibility complex class II molecules

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Differential expression of CLIP:MHC class II and conventional endogenous peptide:MHC class II complexes by thymic epithelial cells and peripheral antigen-presenting cells

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Antigen presentation and T cell development in H2-M-deficient mice

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Positive selection of CD8+ T cells induced by major histocompatibility complex binding peptides in fetal thymic organ culture

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T cell receptor antagonist peptides induce positive selection

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Peptides presented to the immune system by the murine class II major histocompatibility complex molecule I-Ad

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The repertoire of T cells shaped by a single MHC/peptide ligand.

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Specificity and flexibility in thymic selection

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Positive selection of thymocytes

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Cassette vectors directing expression of T cell receptor genes in transgenic mice

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Unopposed positive selection and autoreactivity in mice expressing class II MHC only on thymic cortex

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Correcting an immune-response deficiency by creating Eα gene transgenic mice

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H2-M mutant mice are defective in the peptide loading of class II molecules, antigen presentation, and T cell repertoire selection

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A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides

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Mice lacking H2-M complexes, enigmatic elements of the MHC class II peptide-loading pathway

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A novel MHC class II epitope expressed in thymic medulla but not cortex

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7 January 2021

Positive selection of T cells induced by viral delivery of neopeptides to the thymus

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7 January 2021

Potent effects of low levels of MHC class II-associated invariant chain on CD4+ T cell development

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7 January 2021

Identification of the naturally processed form of hen egg white lysozyme bound to the murine major histocompatibility complex class II molecule I-Ak

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7 January 2021

Lower receptor avidity required for thymic clonal deletion than for effector T-cell function

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7 January 2021

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7 January 2021

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Positive and negative thymocyte selection induced by different concentrations of a single peptide

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Identifiers

DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:9285405%20AND%20SRC:MED&resulttype=core&format=json

5 November 2019

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