Association Analysis of Genetic Polymorphisms in Genes Related to Sunitinib Pharmacokinetics, Specifically Clearance of Sunitinib and SU12662 (Q60860281)

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English	Association Analysis of Genetic Polymorphisms in Genes Related to Sunitinib Pharmacokinetics, Specifically Clearance of Sunitinib and SU12662	article

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scholarly article

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8 March 2020

Association analysis of genetic polymorphisms in genes related to sunitinib pharmacokinetics, specifically clearance of sunitinib and SU12662 (English)

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8 March 2020

pharmacokinetics

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Meta H Diekstra

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8 March 2020

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8 March 2020

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8 March 2020

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H J Klümpen

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8 March 2020

M P J K Lolkema

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8 March 2020

H Yu

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8 March 2020

J S L Kloth

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8 March 2020

H Gelderblom

6

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8 March 2020

R H N van Schaik

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8 March 2020

A D R Huitema

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8 March 2020

N Steeghs

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8 March 2020

R H J Mathijssen

12

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24 February 2014

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8 March 2020

Clinical Pharmacology & Therapeutics

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8 March 2020

96

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8 March 2020

1

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8 March 2020

81-89

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8 March 2020

Pharmacogenetic pathway analysis for determination of sunitinib-induced toxicity

1 reference

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7 January 2021

based on heuristic

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Single nucleotide polymorphism associations with response and toxic effects in patients with advanced renal-cell carcinoma treated with first-line sunitinib: a multicentre, observational, prospective study

1 reference

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7 January 2021

based on heuristic

inferred from DOI database lookup

Genetic polymorphisms associated with a prolonged progression-free survival in patients with metastatic renal cell cancer treated with sunitinib

1 reference

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7 January 2021

based on heuristic

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A population pharmacokinetic meta-analysis of sunitinib malate (SU11248) and its primary metabolite (SU12662) in healthy volunteers and oncology patients

1 reference

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Safety, pharmacokinetic, and antitumor activity of SU11248, a novel oral multitarget tyrosine kinase inhibitor, in patients with cancer

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Activity of sunitinib in patients with advanced neuroendocrine tumors

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Novel single nucleotide polymorphisms in the promoter and intron 1 of human pregnane X receptor/NR1I2 and their association with CYP3A4 expression

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Brain accumulation of sunitinib is restricted by P-glycoprotein (ABCB1) and breast cancer resistance protein (ABCG2) and can be enhanced by oral elacridar and sunitinib coadministration.

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Opposing regulation of cytochrome P450 expression by CAR and PXR in hypothyroid mice

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Relationship between exposure to sunitinib and efficacy and tolerability endpoints in patients with cancer: results of a pharmacokinetic/pharmacodynamic meta-analysis.

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Hypertension as a biomarker of efficacy in patients with metastatic renal cell carcinoma treated with sunitinib

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A new functional CYP3A4 intron 6 polymorphism significantly affects tacrolimus pharmacokinetics in kidney transplant recipients.

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7 January 2021

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CYP3A4 intron 6 C>T SNP (CYP3A4*22) encodes lower CYP3A4 activity in cancer patients, as measured with probes midazolam and erythromycin

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CYP3A4*22 genotype and systemic exposure affect paclitaxel-induced neurotoxicity.

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The P450 oxidoreductase *28 SNP is associated with low initial tacrolimus exposure and increased dose requirements in CYP3A5-expressing renal recipients

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Impact of POR*28 on the clinical pharmacokinetics of CYP3A phenotyping probes midazolam and erythromycin.

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CYP3A4*22: promising newly identified CYP3A4 variant allele for personalizing pharmacotherapy

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Pazopanib efficacy in renal cell carcinoma: evidence for predictive genetic markers in angiogenesis-related and exposure-related genes.

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The P450 oxidoreductase genotype is associated with CYP3A activity in vivo as measured by the midazolam phenotyping test

1 reference

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7 January 2021

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Predictive value of CYP3A and ABCB1 phenotyping probes for the pharmacokinetics of sunitinib: the ClearSun study

1 reference

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Midazolam as a phenotyping probe to predict sunitinib exposure in patients with cancer

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PKPD Modeling of Predictors for Adverse Effects and Overall Survival in Sunitinib-Treated Patients With GIST.

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PKPD Modeling of VEGF, sVEGFR-2, sVEGFR-3, and sKIT as Predictors of Tumor Dynamics and Overall Survival Following Sunitinib Treatment in GIST

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Intronic polymorphism in CYP3A4 affects hepatic expression and response to statin drugs

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Pharmacogenomics of Cytochrome P450 3A4: Recent Progress Toward the "Missing Heritability" Problem

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Evidence for therapeutic drug monitoring of targeted anticancer therapies

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10.1038/CLPT.2014.47

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Europe PubMed Central

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8 March 2020

PubMed publication ID

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:24566734%20AND%20SRC:MED&resulttype=core&format=json

8 March 2020

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