Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma (Q61521806)

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10 March 2020

title

Helicobacter pylori secreted peptidyl prolyl cis, trans-isomerase drives Th17 inflammation in gastric adenocarcinoma (English)

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gastric adenocarcinoma

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Helicobacter pylori infectious disease

inferred from title

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1

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Giacomo Emmi

9

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Giuseppe Zanotti

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Mario Milco D'Elios

13

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author name string

Fabio Munari

2

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Chiara Della Bella

3

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Elena Niccolai

4

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Marisa Benagiano

5

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Lapo Bencini

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Fabio Cianchi

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Marco Farsi

8

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Marina de Bernard

11

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Manikuntala Kundu

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publication date

5 October 2012

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Internal and emergency medicine

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published in

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volume

9

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issue

3

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page(s)

303-309

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https://scigraph.springernature.com/pub.10.1007/s11739-012-0867-9

10 March 2020

exact match

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A critical function for transforming growth factor-β, interleukin 23 and proinflammatory cytokines in driving and modulating human TH-17 responses

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Extracellular signal-regulated protein kinase mediates interleukin 17 (IL-17)-induced IL-8 secretion in Helicobacter pylori-infected human gastric epithelial cells.

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IL-21 is highly produced in Helicobacter pylori-infected gastric mucosa and promotes gelatinases synthesis.

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The secreted peptidyl prolyl cis,trans-isomerase HP0175 of Helicobacter pylori induces apoptosis of gastric epithelial cells in a TLR4- and apoptosis signal-regulating kinase 1-dependent manner

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IL-23 promotes tumour incidence and growth

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TLR4-dependent NF-kappaB activation and mitogen- and stress-activated protein kinase 1-triggered phosphorylation events are central to Helicobacter pylori peptidyl prolyl cis-, trans-isomerase (HP0175)-mediated induction of IL-6 release from macropha

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Helicobacter pylori-induced Th17 responses modulate Th1 cell responses, benefit bacterial growth, and contribute to pathology in mice

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Different cytokine profile and antigen-specificity repertoire inHelicobacter pylori-specific T cell clones from the antrum of chronic gastritis patients with or without peptic ulcer

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T helper 1 effector cells specific for Helicobacter pylori in the gastric antrum of patients with peptic ulcer disease

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10.1007/S11739-012-0867-9

Identifiers

DOI

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10 March 2020

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