IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness (Q61625312)

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21 February 2020

title

IL-27 stimulates human NK-cell effector functions and primes NK cells for IL-18 responsiveness (English)

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21 February 2020

2

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21 February 2020

Raúl German Spallanzani

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21 February 2020

Mercedes Fuertes

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21 February 2020

Norberto Zwirner

9

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21 February 2020

author name string

Andrea Ziblat

1

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21 February 2020

Ximena L Raffo Iraolagoitia

4

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21 February 2020

Lucas E Rossi

5

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21 February 2020

Damián E Avila

6

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21 February 2020

Nicolás I Torres

7

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21 February 2020

language of work or name

English

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publication date

2 December 2014

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European Journal of Immunology

21 February 2020

published in

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21 February 2020

volume

45

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21 February 2020

issue

1

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page(s)

192-202

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Evolutionary struggles between NK cells and viruses

21 February 2020

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IL-27, a heterodimeric cytokine composed of EBI3 and p28 protein, induces proliferation of naive CD4+ T cells

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IL-27 regulates IL-12 responsiveness of naive CD4+ T cells through Stat1-dependent and -independent mechanisms

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IL-27 and IFN-αSignal via Stat1 and Stat3 and Induce T-Bet and IL-12Rβ2 in Naive T Cells

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IL-27 promotes T cell-dependent colitis through multiple mechanisms

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IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

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Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10.

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IL-27 increases the proliferation and effector functions of human naïve CD8+ T lymphocytes and promotes their development into Tc1 cells

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Expression of interleukins-23 and 27 leads to successful gene therapy of hepatocellular carcinoma

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IL-27-mediated activation of natural killer cells and inflammation produced antitumour effects for human oesophageal carcinoma cells

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Interleukin-27 activates natural killer cells and suppresses NK-resistant head and neck squamous cell carcinoma through inducing antibody-dependent cellular cytotoxicity.

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Interleukin-23 and interleukin-27 exert quite different antitumor and vaccine effects on poorly immunogenic melanoma.

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Critical role of dendritic cell-derived IL-27 in antitumor immunity through regulating the recruitment and activation of NK and NKT cells.

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IL-27 imparts immunoregulatory function to human NK cell subsets

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Fludarabine-induced immunosuppression is associated with inhibition of STAT1 signaling

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Natural killer cell-produced IFN-γ and TNF-α induce target cell cytolysis through up-regulation of ICAM-1.

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Lipopolysaccharide-mediated IL-10 transcriptional regulation requires sequential induction of type I IFNs and IL-27 in macrophages

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Suppression of TNF-α and IL-1 signaling identifies a mechanism of homeostatic regulation of macrophages by IL-27

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IL-27-producing CD14(+) cells infiltrate inflamed joints of rheumatoid arthritis and regulate inflammation and chemotactic migration

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Expression of interleukin-12-related cytokine transcripts in inflammatory bowel disease: elevated interleukin-23p19 and interleukin-27p28 in Crohn's disease but not in ulcerative colitis

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7 January 2021

IL-27 acts as a priming signal for IL-23 but not IL-12 production on human antigen-presenting cells

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Anti-leukemic properties of IL-12, IL-23 and IL-27: differences and similarities in the control of pediatric B acute lymphoblastic leukemia.

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

NK/iDC interaction results in IL-18 secretion by DCs at the synaptic cleft followed by NK cell activation and release of the DC maturation factor HMGB1

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7 January 2021

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7 January 2021

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7 January 2021

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7 January 2021

Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression.

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7 January 2021

Identifiers

DOI

10.1002/EJI.201444699

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:25308526%20AND%20SRC:MED&resulttype=core&format=json

21 February 2020

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