Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy (Q61631846)

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title

Heterogeneous distribution of K-ras mutations in primary colon carcinomas: implications for EGFR-directed therapy (English)

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6

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9

Rune Smaaland

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Bjørnar Gilje

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Oddmund Nordgård

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author name string

Satu Oltedal

1

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Ole Gunnar Aasprong

2

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Hartwig Kørner

4

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Reino Heikkilä

8

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Jannicke H Møller

3

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Elke M Birkemeyer

7

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publication date

15 May 2011

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International Journal of Colorectal Disease

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published in

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volume

26

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issue

10

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page(s)

1271-1277

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Molecular changes in the Ki-ras and APC genes in primary colorectal carcinoma and synchronous metastases compared with the findings in accompanying adenomas

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cites work

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12 December 2020

Clonal analysis of colorectal tumors using K-ras and p53 gene mutations as markers

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12 December 2020

High concordance of KRAS status between primary colorectal tumors and related metastatic sites: implications for clinical practice

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12 December 2020

Quantitative RT-PCR detection of tumor cells in sentinel lymph nodes isolated from colon cancer patients with an ex vivo approach

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Analysis of Ki-ras gene mutations within the same tumor using a single tumor crypt in colorectal carcinomas.

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Prevalence and heterogeneity of KRAS, BRAF, and PIK3CA mutations in primary colorectal adenocarcinomas and their corresponding metastases

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Detection of occult metastases in sentinel lymph nodes from colon cancer patients by K-ras mutation peptide nucleic acid clamp PCR.

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Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer

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Kirsten ras mutations in patients with colorectal cancer: the multicenter "RASCAL" study

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KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implications

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Cancer statistics, 2009

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American Society of Clinical Oncology provisional clinical opinion: testing for KRAS gene mutations in patients with metastatic colorectal carcinoma to predict response to anti-epidermal growth factor receptor monoclonal antibody therapy

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12 December 2020

High-fidelity DNA polymerase enhances the sensitivity of a peptide nucleic acid clamp PCR assay for K-ras mutations

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12 December 2020

Intratumoral heterogeneity of genetic changes in primary colorectal carcinomas with metastasis

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12 December 2020

Discordance between K-ras mutations in bone marrow micrometastases and the primary tumor in colorectal cancer.

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12 December 2020

Simple and sensitive detection of mutations in the ras proto-oncogenes using PNA-mediated PCR clamping

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12 December 2020

Intratumor genetic heterogeneity in advanced human colorectal adenocarcinoma.

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12 December 2020

Peptide nucleic acid clamp PCR: a novel K-ras mutation detection assay for colorectal cancer micrometastases in lymph nodes

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12 December 2020

K-ras mutations and benefit from cetuximab in advanced colorectal cancer.

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12 December 2020

Structural differences between valine-12 and aspartate-12 Ras proteins may modify carcinoma aggression.

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12 December 2020

Acquired KRAS mutations during progression of colorectal cancer metastases: possible implications for therapy and prognosis

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12 December 2020

A genetic model for colorectal tumorigenesis

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12 December 2020

Biomarkers predicting clinical outcome of epidermal growth factor receptor-targeted therapy in metastatic colorectal cancer

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12 December 2020

Intratumor heterogeneity of K-ras2 mutations in colorectal adenocarcinomas: association with degree of DNA aneuploidy

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12 December 2020

Biological properties of human c-Ha-ras1 genes mutated at codon 12.

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12 December 2020

Detection of mutations in EGFR in circulating lung-cancer cells

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12 December 2020

Genetic heterogeneity of the c-K-ras locus in colorectal adenomas but not in adenocarcinomas.

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12 December 2020

Evolution of intratumoral genetic heterogeneity during colorectal cancer progression.

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12 December 2020

Heterogeneity of mutant versus wild-type Ki-ras in primary and metastatic colorectal carcinomas, and association of codon-12 valine with early mortality

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12 December 2020

Genetic alterations during colorectal-tumor development

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12 December 2020

Patient with colorectal cancer with heterogeneous KRAS molecular status responding to cetuximab-based chemotherapy

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12 December 2020

Mutations of KRAS and BRAF in primary and matched metastatic sites of colorectal cancer

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12 December 2020

Cancer stem cells in solid tumours: accumulating evidence and unresolved questions

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12 December 2020

Assessment of K-ras mutation: a step toward personalized medicine for patients with colorectal cancer

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12 December 2020