Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism (Q61814884)

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19 April 2020

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Middle East Respiratory Syndrome Vaccine Candidates: Cautious Optimism (English)

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30658390%20AND%20SRC:MED&resulttype=core&format=json

Middle East respiratory syndrome coronavirus

19 April 2020

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3 November 2019

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RNA virus infectious disease

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Middle East respiratory syndrome

1 July 2020

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1

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Vineet D. Menachery

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Craig Schindewolf

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Vineet D Menachery

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2

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English

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publication date

17 January 2019

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20 June 2019

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Creative Commons Attribution

19 April 2020

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3 November 2019

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Nonreplicating vaccinia vector efficiently expresses recombinant genes

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12 December 2020

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells.

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12 December 2020

Coronavirus infections of man associated with diseases other than the common cold

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Potential DNA vaccine integration into host cell genome

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Mechanisms of antigen uptake for presentation

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Replicon-helper systems from attenuated Venezuelan equine encephalitis virus: expression of heterologous genes in vitro and immunization against heterologous pathogens in vivo

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Gene transfer into muscle by electroporation in vivo.

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The carboxy-terminal domain initiates trimerization of bacteriophage T4 fibritin

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Immunogenicity of DNA vaccines expressing tuberculosis proteins fused to tissue plasminogen activator signal sequences

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Immune responses to adenovirus and adeno-associated virus in humans.

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Antibody and virus: binding and neutralization

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Design and production of recombinant subunit vaccines.

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Safety of modified vaccinia virus Ankara (MVA) in immune-suppressed macaques.

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Replication-defective vector based on a chimpanzee adenovirus

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Characterization of a novel coronavirus associated with severe acute respiratory syndrome

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Induction of SARS-nucleoprotein-specific immune response by use of DNA vaccine

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Specific antibodies modulate the interactions of adenovirus type 5 with dendritic cells

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Vesicular stomatitis virus: re-inventing the bullet

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T-cell epitopes in severe acute respiratory syndrome (SARS) coronavirus spike protein elicit a specific T-cell immune response in patients who recover from SARS.

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Contributions of the structural proteins of severe acute respiratory syndrome coronavirus to protective immunity

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Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface

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Vaccines: past, present and future

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A human T-cell leukemia virus type 1 regulatory element enhances the immunogenicity of human immunodeficiency virus type 1 DNA vaccines in mice and nonhuman primates

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Severe acute respiratory syndrome coronavirus-like virus in Chinese horseshoe bats

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Bats are natural reservoirs of SARS-like coronaviruses

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Biodistribution of DNA Plasmid Vaccines against HIV-1, Ebola, Severe Acute Respiratory Syndrome, or West Nile Virus Is Similar, without Integration, despite Differing Plasmid Backbones or Gene Inserts

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Antibodies against trimeric S glycoprotein protect hamsters against SARS-CoV challenge despite their capacity to mediate FcgammaRII-dependent entry into B cells in vitro.

1 reference

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Vaccine efficacy in senescent mice challenged with recombinant SARS-CoV bearing epidemic and zoonotic spike variants

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Novel adenovirus vaccine vectors based on the enteric-tropic serotype 41

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Attenuated measles virus as a vaccine vector

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The SARS-CoV nucleocapsid protein: a protein with multifarious activities

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A live attenuated severe acute respiratory syndrome coronavirus is immunogenic and efficacious in golden Syrian hamsters

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Cross-reactive HIV-1-neutralizing activity of serum IgG from a rabbit immunized with gp41 fused to IgG1 Fc: possible role of the prolonged half-life of the immunogen

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12 December 2020

The spike protein of SARS-CoV--a target for vaccine and therapeutic development

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12 December 2020

Geographic dependence, surveillance, and origins of the 2009 influenza A (H1N1) virus

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12 December 2020

International epidemiology of human pre-existing adenovirus (Ad) type-5, type-6, type-26 and type-36 neutralizing antibodies: Correlates of high Ad5 titers and implications for potential HIV vaccine trials

1 reference

12 December 2020

Potent and persistent antibody responses against the receptor-binding domain of SARS-CoV spike protein in recovered patients

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12 December 2020

DNA vaccines: an historical perspective and view to the future

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12 December 2020

Ribose 2'-O-methylation provides a molecular signature for the distinction of self and non-self mRNA dependent on the RNA sensor Mda5.

1 reference

12 December 2020

Viral vectors as vaccine platforms: deployment in sight

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12 December 2020

Electroporation delivery of DNA vaccines: prospects for success

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12 December 2020

A double-inactivated severe acute respiratory syndrome coronavirus vaccine provides incomplete protection in mice and induces increased eosinophilic proinflammatory pulmonary response upon challenge

1 reference

12 December 2020

Robust immune response elicited by a novel and unique Mycobacterium tuberculosis protein using an optimized DNA/protein heterologous prime/boost protocol

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12 December 2020

Immunization with SARS coronavirus vaccines leads to pulmonary immunopathology on challenge with the SARS virus

1 reference

12 December 2020

The coronavirus E protein: assembly and beyond

1 reference

12 December 2020

Construction and characterization of virus-like particles: a review

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12 December 2020

A live, impaired-fidelity coronavirus vaccine protects in an aged, immunocompromised mouse model of lethal disease

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12 December 2020

Dipeptidyl peptidase 4 is a functional receptor for the emerging human coronavirus-EMC

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12 December 2020

Evidence of person-to-person transmission within a family cluster of novel coronavirus infections, United Kingdom, February 2013.

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12 December 2020

The receptor binding domain of the new Middle East respiratory syndrome coronavirus maps to a 231-residue region in the spike protein that efficiently elicits neutralizing antibodies

1 reference

12 December 2020

Identification of a receptor-binding domain in the S protein of the novel human coronavirus Middle East respiratory syndrome coronavirus as an essential target for vaccine development

1 reference

12 December 2020

Middle East respiratory syndrome coronavirus spike protein delivered by modified vaccinia virus Ankara efficiently induces virus-neutralizing antibodies

1 reference

12 December 2020

Engineering a replication-competent, propagation-defective Middle East respiratory syndrome coronavirus as a vaccine candidate

1 reference

12 December 2020

Efficacy trial of a DNA/rAd5 HIV-1 preventive vaccine

1 reference

12 December 2020

Structure-Based Design of a Fusion Glycoprotein Vaccine for Respiratory Syncytial Virus

1 reference

12 December 2020

Wild-type and innate immune-deficient mice are not susceptible to the Middle East respiratory syndrome coronavirus

1 reference

12 December 2020

Evaluation of serologic and antigenic relationships between middle eastern respiratory syndrome coronavirus and other coronaviruses to develop vaccine platforms for the rapid response to emerging coronaviruses

1 reference

12 December 2020

Attenuation and restoration of severe acute respiratory syndrome coronavirus mutant lacking 2'-o-methyltransferase activity

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12 December 2020

Intranasal vaccination with recombinant receptor-binding domain of MERS-CoV spike protein induces much stronger local mucosal immune responses than subcutaneous immunization: Implication for designing novel mucosal MERS vaccines.

1 reference

12 December 2020

Mouse dipeptidyl peptidase 4 is not a functional receptor for Middle East respiratory syndrome coronavirus infection

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12 December 2020

Rapid generation of a mouse model for Middle East respiratory syndrome

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12 December 2020

Purified coronavirus spike protein nanoparticles induce coronavirus neutralizing antibodies in mice

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12 December 2020

Emergence of Zaire Ebola Virus Disease in Guinea

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12 December 2020

Current advancements and potential strategies in the development of MERS-CoV vaccines

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12 December 2020

Potent neutralization of MERS-CoV by human neutralizing monoclonal antibodies to the viral spike glycoprotein

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12 December 2020

Repurposing of clinically developed drugs for treatment of Middle East respiratory syndrome coronavirus infection

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12 December 2020

T cell-mediated immune response to respiratory coronaviruses

1 reference

12 December 2020

Effects of Toll-like receptor stimulation on eosinophilic infiltration in lungs of BALB/c mice immunized with UV-inactivated severe acute respiratory syndrome-related coronavirus vaccine

1 reference

12 December 2020

Evidence for camel-to-human transmission of MERS coronavirus

1 reference

12 December 2020

Calling for rapid development of a safe and effective MERS vaccine.

1 reference

12 December 2020

Accessory proteins of SARS-CoV and other coronaviruses

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12 December 2020

Immunogenicity of an adenoviral-based Middle East Respiratory Syndrome coronavirus vaccine in BALB/c mice

1 reference

12 December 2020

Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak

1 reference

12 December 2020

Searching for an ideal vaccine candidate among different MERS coronavirus receptor-binding fragments--the importance of immunofocusing in subunit vaccine design

1 reference

12 December 2020

Host cell entry of Middle East respiratory syndrome coronavirus after two-step, furin-mediated activation of the spike protein

1 reference

12 December 2020

MERS coronavirus neutralizing antibodies in camels, Eastern Africa, 1983-1997.

1 reference

12 December 2020

Chimpanzee Adenovirus Vector Ebola Vaccine — Preliminary Report

1 reference

12 December 2020

Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection

1 reference

12 December 2020

Systemic and mucosal immunity in mice elicited by a single immunization with human adenovirus type 5 or 41 vector-based vaccines carrying the spike protein of Middle East respiratory syndrome coronavirus

1 reference

12 December 2020

Middle East respiratory syndrome coronavirus: another zoonotic betacoronavirus causing SARS-like disease

1 reference

12 December 2020

Protective Efficacy of Recombinant Modified Vaccinia Virus Ankara Delivering Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein

1 reference

12 December 2020

Middle East respiratory syndrome.

1 reference

12 December 2020

Preclinical Development of Inactivated Rabies Virus-Based Polyvalent Vaccine Against Rabies and Filoviruses

1 reference

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Effects of the fusion design and immunization route on the immunogenicity of Ag85A-Mtb32 in adenoviral vectored tuberculosis vaccine

1 reference

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Pre- and postexposure efficacy of fully human antibodies against Spike protein in a novel humanized mouse model of MERS-CoV infection

1 reference

12 December 2020

Evaluation of candidate vaccine approaches for MERS-CoV.

1 reference

12 December 2020

A synthetic consensus anti-spike protein DNA vaccine induces protective immunity against Middle East respiratory syndrome coronavirus in nonhuman primates

1 reference

12 December 2020

A Highly Immunogenic and Protective Middle East Respiratory Syndrome Coronavirus Vaccine Based on a Recombinant Measles Virus Vaccine Platform.

1 reference

12 December 2020

Characterization and Demonstration of the Value of a Lethal Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease

1 reference

12 December 2020

A SARS-like cluster of circulating bat coronaviruses shows potential for human emergence

1 reference

12 December 2020

Recombinant Receptor Binding Domain Protein Induces Partial Protective Immunity in Rhesus Macaques Against Middle East Respiratory Syndrome Coronavirus Challenge

1 reference

12 December 2020

An orthopoxvirus-based vaccine reduces virus excretion after MERS-CoV infection in dromedary camels

1 reference

12 December 2020

Recent insights into the development of therapeutics against coronavirus diseases by targeting N protein

1 reference

12 December 2020

Coronaviruses - drug discovery and therapeutic options.

1 reference

12 December 2020

High-Resolution Analysis of Coronavirus Gene Expression by RNA Sequencing and Ribosome Profiling.

1 reference

12 December 2020

MERS-CoV virus-like particles produced in insect cells induce specific humoural and cellular imminity in rhesus macaques

1 reference

12 December 2020

Immunization with inactivated Middle East Respiratory Syndrome coronavirus vaccine leads to lung immunopathology on challenge with live virus

1 reference

12 December 2020

Airway Memory CD4(+) T Cells Mediate Protective Immunity against Emerging Respiratory Coronaviruses

1 reference

12 December 2020

Newcastle Disease Virus as a Vaccine Vector for Development of Human and Veterinary Vaccines

1 reference

12 December 2020

MERS-CoV spike protein: Targets for vaccines and therapeutics

1 reference

12 December 2020

The Nonstructural Proteins Directing Coronavirus RNA Synthesis and Processing.

1 reference

12 December 2020

A recombinant receptor-binding domain of MERS-CoV in trimeric form protects human dipeptidyl peptidase 4 (hDPP4) transgenic mice from MERS-CoV infection

1 reference

12 December 2020

Recombinant Receptor-Binding Domains of Multiple Middle East Respiratory Syndrome Coronaviruses (MERS-CoVs) Induce Cross-Neutralizing Antibodies against Divergent Human and Camel MERS-CoVs and Antibody Escape Mutants

1 reference

12 December 2020

One-Health: a Safe, Efficient, Dual-Use Vaccine for Humans and Animals against Middle East Respiratory Syndrome Coronavirus and Rabies Virus

1 reference

12 December 2020

A mouse model for MERS coronavirus-induced acute respiratory distress syndrome

1 reference

12 December 2020

The recombinant N-terminal domain of spike proteins is a potential vaccine against Middle East respiratory syndrome coronavirus (MERS-CoV) infection

1 reference

12 December 2020

Novel chimeric virus-like particles vaccine displaying MERS-CoV receptor-binding domain induce specific humoral and cellular immune response in mice

1 reference

12 December 2020

MERS-CoV spike nanoparticles protect mice from MERS-CoV infection

1 reference

12 December 2020

DNA vaccine encoding Middle East respiratory syndrome coronavirus S1 protein induces protective immune responses in mice

1 reference

12 December 2020

Immunogenicity of Candidate MERS-CoV DNA Vaccines Based on the Spike Protein

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12 December 2020

Mouse-adapted MERS coronavirus causes lethal lung disease in human DPP4 knockin mice

1 reference

12 December 2020

Further Evidence for Bats as the Evolutionary Source of Middle East Respiratory Syndrome Coronavirus

1 reference

12 December 2020

ChAdOx1 and MVA based vaccine candidates against MERS-CoV elicit neutralising antibodies and cellular immune responses in mice

1 reference

12 December 2020

Searching for animal models and potential target species for emerging pathogens: Experience gained from Middle East respiratory syndrome (MERS) coronavirus

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12 December 2020

Recovery from the Middle East respiratory syndrome is associated with antibody and T-cell responses.

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12 December 2020

Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen.

1 reference

12 December 2020

MERS-CoV Accessory ORFs Play Key Role for Infection and Pathogenesis

1 reference

12 December 2020

Identification of sialic acid-binding function for the Middle East respiratory syndrome coronavirus spike glycoprotein.

1 reference

12 December 2020

Middle East Respiratory Syndrome Coronavirus Nonstructural Protein 16 Is Necessary for Interferon Resistance and Viral Pathogenesis

1 reference

12 December 2020

A recombinant VSV-vectored MERS-CoV vaccine induces neutralizing antibody and T cell responses in rhesus monkeys after single dose immunization

1 reference

12 December 2020

Protective efficacy of a novel simian adenovirus vaccine against lethal MERS-CoV challenge in a transgenic human DPP4 mouse model

1 reference

12 December 2020

Pathogenicity and Viral Shedding of MERS-CoV in Immunocompromised Rhesus Macaques.

1 reference

12 December 2020

Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen.

1 reference

12 December 2020

Development of a Broadly Accessible Venezuelan Equine Encephalitis Virus Replicon Particle Vaccine Platform.

1 reference

12 December 2020

Enhanced protection in mice induced by immunization with inactivated whole viruses compare to spike protein of middle east respiratory syndrome coronavirus.

1 reference

12 December 2020

Heterologous prime-boost vaccination with adenoviral vector and protein nanoparticles induces both Th1 and Th2 responses against Middle East respiratory syndrome coronavirus.

1 reference

12 December 2020

Distribution and absence of generalized lesions in mice following single dose intramuscular inoculation of the vaccine candidate MVA-MERS-S

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12 December 2020

Live-attenuated bivalent measles virus-derived vaccines targeting Middle East respiratory syndrome coronavirus induce robust and multifunctional T cell responses against both viruses in an appropriate mouse model

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12 December 2020

Combination Attenuation Offers Strategy for Live Attenuated Coronavirus Vaccines

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12 December 2020

Identifiers

DOI

10.3390/V11010074

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30658390%20AND%20SRC:MED&resulttype=core&format=json

19 April 2020

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19 April 2020

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