Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity (Q61861295)

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24 February 2019

title

Small Heterodimer Partner Regulates Circadian Cytochromes p450 and Drug-Induced Hepatotoxicity (English)

1 reference

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30555544%20AND%20SRC:MED&resulttype=core&format=json

Hepatic nuclear factor 4, alpha

24 February 2019

main subject

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Nuclear receptor subfamily 0, group B, member 2

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Nuclear receptor subfamily 5, group A, member 2

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HNF1 homeobox A

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Basic helix-loop-helix family, member e41

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Nuclear receptor subfamily 1, group D, member 1

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Nuclear factor, interleukin 3, regulated

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Tianpeng Zhang

1

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24 February 2019

Fangjun Yu

2

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24 February 2019

Lianxia Guo

3

1 reference

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24 February 2019

Min Chen

4

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24 February 2019

Xue Yuan

5

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24 February 2019

Baojian Wu

6

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24 February 2019

publication date

22 October 2018

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24 February 2019

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30555544%20AND%20SRC:MED&resulttype=core&format=json

24 February 2019

volume

8

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issue

19

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page(s)

5246-5258

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An established preadipose cell line and its differentiation in culture II. Factors affecting the adipose conversion

24 February 2019

cites work

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12 December 2020

Role of the liver-enriched transcription factor HNF-1 alpha in expression of the CYP2E1 gene

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Circadian changes in mitoxantrone toxicity in mice: relationship with plasma pharmacokinetics

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The orphan nuclear receptor SHP inhibits agonist-dependent transcriptional activity of estrogen receptors ERalpha and ERbeta

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The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression

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A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis

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Redundant pathways for negative feedback regulation of bile acid production

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Dec1 and Dec2 are regulators of the mammalian molecular clock

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The small heterodimer partner interacts with the pregnane X receptor and represses its transcriptional activity.

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Resistance of SHP-null mice to bile acid-induced liver damage

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12 December 2020

Hepatic expression of cytochrome P450s in hepatocyte nuclear factor 1-alpha (HNF1α)-deficient mice

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12 December 2020

Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).

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Circadian sensitivity to the chemotherapeutic agent cyclophosphamide depends on the functional status of the CLOCK/BMAL1 transactivation complex

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Induction of phase I, II and III drug metabolism/transport by xenobiotics

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12 December 2020

Theophylline pharmacokinetics: comparison of Cyp1a1(-/-) and Cyp1a2(-/-) knockout mice, humanized hCYP1A1_1A2 knock-in mice lacking either the mouse Cyp1a1 or Cyp1a2 gene, and Cyp1(+/+) wild-type mice.

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12 December 2020

Transcriptional corepression by SHP: molecular mechanisms and physiological consequences

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12 December 2020

The circadian PAR-domain basic leucine zipper transcription factors DBP, TEF, and HLF modulate basal and inducible xenobiotic detoxification

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12 December 2020

Synergistic regulation of the mouse orphan nuclear receptor SHP gene promoter by CLOCK-BMAL1 and LRH-1.

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12 December 2020

Crosstalk between xenobiotics metabolism and circadian clock

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12 December 2020

Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver

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12 December 2020

Multiple mechanisms regulate circadian expression of the gene for cholesterol 7alpha-hydroxylase (Cyp7a), a key enzyme in hepatic bile acid biosynthesis

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12 December 2020

Molecular basis for rhythmic expression of CYP3A4 in serum-shocked HepG2 cells

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12 December 2020

Identification of novel toxicity-associated metabolites by metabolomics and mass isotopomer analysis of acetaminophen metabolism in wild-type and Cyp2e1-null mice

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12 December 2020

The molecular mechanism regulating 24-hour rhythm of CYP2E1 expression in the mouse liver

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12 December 2020

Circadian clock-controlled intestinal expression of the multidrug-resistance gene mdr1a in mice

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12 December 2020

A comparative analysis of binding sites between mouse CYP2C38 and CYP2C39 based on homology modeling, molecular dynamics simulation and docking studies

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12 December 2020

Expression, function and regulation of mouse cytochrome P450 enzymes: comparison with human P450 enzymes

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12 December 2020

Transcriptional corepressor SHP recruits SIRT1 histone deacetylase to inhibit LRH-1 transactivation

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12 December 2020

Diurnal regulation of MTP and plasma triglyceride by CLOCK is mediated by SHP.

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12 December 2020

Time-dependent interaction between differentiated embryo chondrocyte-2 and CCAAT/enhancer-binding protein α underlies the circadian expression of CYP2D6 in serum-shocked HepG2 cells

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12 December 2020

Central and peripheral circadian clocks in mammals

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12 December 2020

PCB 126 and other dioxin-like PCBs specifically suppress hepatic PEPCK expression via the aryl hydrocarbon receptor

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12 December 2020

The role of BCS (biopharmaceutics classification system) and BDDCS (biopharmaceutics drug disposition classification system) in drug development

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12 December 2020

The metabolic profile of mitoxantrone and its relation with mitoxantrone-induced cardiotoxicity

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12 December 2020

Molecular architecture of the mammalian circadian clock

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12 December 2020

Metabolism of aflatoxins: key enzymes and interindividual as well as interspecies differences

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12 December 2020

Small heterodimer partner/neuronal PAS domain protein 2 axis regulates the oscillation of liver lipid metabolism

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12 December 2020

The hepatic circadian clock modulates xenobiotic metabolism in mice

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12 December 2020

Hepatocyte circadian clock controls acetaminophen bioactivation through NADPH-cytochrome P450 oxidoreductase

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12 December 2020

Metabolism elucidation of BJ-B11 (a heat shock protein 90 inhibitor) by human liver microsomes: identification of main contributing enzymes.

1 reference

12 December 2020

Small Heterodimer Partner (NR0B2) Coordinates Nutrient Signaling and the Circadian Clock in Mice

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12 December 2020

REV-ERBα Activates C/EBP Homologous Protein to Control Small Heterodimer Partner-Mediated Oscillation of Alcoholic Fatty Liver

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12 December 2020

Transcriptional Regulation of Human UDP-Glucuronosyltransferase 2B10 by Farnesoid X Receptor in Human Hepatoma HepG2 Cells.

1 reference

12 December 2020

Farnesoid X receptor regulates SULT1E1 expression through inhibition of PGC1α binding to HNF4α.

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12 December 2020

REV-ERBa Regulates CYP7A1 through Repression of Liver Receptor Homolog-1.

1 reference

12 December 2020

Identifiers

DOI

10.7150/THNO.28676

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:30555544%20AND%20SRC:MED&resulttype=core&format=json

24 February 2019

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24 February 2019

PubMed publication ID

30555544

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