Keratin 1 (Q6393585)

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mammalian protein found in Homo sapiens

keratin, type II cytoskeletal 1
67 kDa cytokeratin
KRT1
cytokeratin 1
hair alpha protein
CK-1
Cytokeratin-1
type-II keratin Kb1
Keratin-1
K1
keratin 1, type II
epidermolytic hyperkeratosis 1

Language	Label	Description	Also known as
English	Keratin 1	mammalian protein found in Homo sapiens	keratin, type II cytoskeletal 1 67 kDa cytokeratin KRT1 cytokeratin 1 hair alpha protein CK-1 Cytokeratin-1 type-II keratin Kb1 Keratin-1 K1 keratin 1, type II epidermolytic hyperkeratosis 1

Statements

1 reference

13 November 2019

UniProt protein ID

Keratin, type II

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P04264

Intermediate filament, rod domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Keratin type II head, protein family

1 reference

based on heuristic

inferred from protein domain or family

Keratin type II cytoskeletal 1, tail, protein family

1 reference

based on heuristic

inferred from protein domain or family

Intermediate filament protein, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

protein binding

determination method

3 references

8 April 2019

Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

8 April 2019

Interactions between epiplakin and intermediate filaments

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

8 April 2019

Widespread macromolecular interaction perturbations in human genetic disorders

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

structural molecule activity

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

carbohydrate binding

determination method

1 reference

8 April 2019

Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

structural constituent of skin epidermis

determination method

1 reference

8 April 2019

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

signaling receptor activity

determination method

1 reference

8 April 2019

Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

protein heterodimerization activity

determination method

1 reference

8 April 2019

The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

blood microparticle

determination method

1 reference

17 October 2017

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04264&geneProductId=UniProtKB:P04264

determination method

plasma membrane

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

determination method

1 reference

8 April 2019

A leucine----proline mutation in the H1 subdomain of keratin 1 causes epidermolytic hyperkeratosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

determination method

3 references

17 October 2017

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04264&geneProductId=UniProtKB:P04264

determination method

17 October 2017

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04264&geneProductId=UniProtKB:P04264

determination method

17 October 2017

Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04264&geneProductId=UniProtKB:P04264

determination method

determination method

1 reference

17 October 2017

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04264&geneProductId=UniProtKB:P04264

determination method

extracellular exosome

determination method

4 references

17 October 2017

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04264&geneProductId=UniProtKB:P04264

determination method

17 October 2017

Proteomic analysis of podocyte exosome-enriched fraction from normal human urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04264&geneProductId=UniProtKB:P04264

determination method

17 October 2017

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04264&geneProductId=UniProtKB:P04264

determination method

17 October 2017

Intestinal epithelial cells secrete exosome-like vesicles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04264&geneProductId=UniProtKB:P04264

determination method

extracellular region

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

extracellular space

determination method

2 references

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

ficolin-1-rich granule lumen

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

cornified envelope

determination method

1 reference

8 April 2019

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

extracellular space

determination method

determination method

1 reference

8 April 2019

Proteomic characterization of the human sperm nucleus

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

determination method

3 references

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

8 April 2019

Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

8 April 2019

Defining the membrane proteome of NK cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

collagen-containing extracellular matrix

determination method

1 reference

8 April 2019

Comparative proteomic analysis of supportive and unsupportive extracellular matrix substrates for human embryonic stem cell maintenance

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

extracellular exosome

determination method

3 references

8 April 2019

Proteomic analysis of human parotid gland exosomes by multidimensional protein identification technology (MudPIT)

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

8 April 2019

In-depth proteomic analyses of exosomes isolated from expressed prostatic secretions in urine

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

8 April 2019

Intestinal epithelial cells secrete exosome-like vesicles

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

blood microparticle

determination method

1 reference

8 April 2019

Proteomic analysis of microvesicles from plasma of healthy donors reveals high individual variability

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

biological process

complement activation, lectin pathway

determination method

1 reference

8 April 2019

Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

retina homeostasis

determination method

1 reference

17 October 2017

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P04264&geneProductId=UniProtKB:P04264

determination method

regulation of angiogenesis

determination method

1 reference

8 April 2019

Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

negative regulation of inflammatory response

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

response to oxidative stress

determination method

1 reference

8 April 2019

Endothelial oxidative stress activates the lectin complement pathway: role of cytokeratin 1

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

determination method

1 reference

8 April 2019

Expression and colocalization of cytokeratin 1 and urokinase plasminogen activator receptor on endothelial cells

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

establishment of skin barrier

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

neutrophil degranulation

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

peptide cross-linking

determination method

1 reference

8 April 2019

The proteins elafin, filaggrin, keratin intermediate filaments, loricrin, and small proline-rich proteins 1 and 2 are isodipeptide cross-linked components of the human epidermal cornified cell envelope

Critical Assessment of Protein Function Annotation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

retina homeostasis

determination method

1 reference

8 April 2019

Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naïve to therapy

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

protein heterotetramerization

determination method

1 reference

8 April 2019

The X-Ray Crystal Structure of the Keratin 1-Keratin 10 Helix 2B Heterodimer Reveals Molecular Surface Properties and Biochemical Insights into Human Skin Disease.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P04264

determination method

Gene Atlas image

PBB GE KRT1 205900 at fs.png
732 × 530; 8 KB

0 references

Identifiers

MeSH descriptor ID

subject named as

Keratin-1

0 references

D05.750.078.593.450.600.100

0 references

D12.776.220.475.450.600.100

0 references

D12.776.860.607.650.100

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000252244

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000252244

PDB structure ID

1 reference

UniProt protein ID

9 August 2016

language of work or name

1 reference

based on heuristic

inferred by common MeSH mappings on source and on Wikidata

25 May 2023

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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