Antiviral therapeutic approaches for human rhinovirus infections (Q64450546)

12 December 2020

Successful Prophylaxis against Rabies in Mice and Rhesus Monkeys: The Interferon System and Vaccine

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12 December 2020

Human-murine chimeras of ICAM-1 identify amino acid residues critical for rhinovirus and antibody binding

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12 December 2020

Respiratory virus infection of monolayer cultures of human nasal epithelial cells

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12 December 2020

Prophylactic and therapeutic efficacy of poly(I,C)-LC against Rift Valley fever virus infection in mice

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12 December 2020

The site of attachment in human rhinovirus 14 for antiviral agents that inhibit uncoating

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12 December 2020

Lassa fever. Effective therapy with ribavirin

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12 December 2020

Inhibition of interferon action by actinomycin.

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12 December 2020

Prospects for the use of double-stranded ribonucleic acid (poly I:C) inducers in man.

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12 December 2020

Evaluation of an interferon inducer in viral respiratory disease.

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12 December 2020

Poly I:C, an inducer of interferon and interference against virus infections

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12 December 2020

Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes

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12 December 2020

Molecular basis of interferon action: inhibition of viral RNA translation

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12 December 2020

Clinical efficacy of ribavirin in the treatment of genital herpes simplex virus infection

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12 December 2020

Antiviral activity and mechanism of action of 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (MDL-860).

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12 December 2020

Activity of 2-(3,4-dichlorophenoxy)-5-nitrobenzonitrile (MDL-860) against picornaviruses in vitro

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12 December 2020

Crimean Congo-Haemorrhagic Fever treated with oral ribavirin

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12 December 2020

Localization of human rhinovirus replication in the upper respiratory tract by in situ hybridization

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12 December 2020

Community study of role of viral infections in exacerbations of asthma in 9-11 year old children

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12 December 2020

Multicenter clinical trial of oral ribavirin in symptomatic HIV-infected patients. The Ribavirin ARC Study Group

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12 December 2020

Prophylactic and therapeutic efficacies of poly(IC.LC) against respiratory influenza A virus infection in mice

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12 December 2020

Neutralizing antibody to human rhinovirus 14 penetrates the receptor-binding canyon.

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12 December 2020

Detection of rhinovirus RNA in lower airway cells during experimentally induced infection

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12 December 2020

Epidemiology, pathogenesis, and treatment of the common cold

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12 December 2020

Viruses and bacteria in the etiology of the common cold

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12 December 2020

Antibody-mediated neutralization of human rhinovirus 14 explored by means of cryoelectron microscopy and X-ray crystallography of virus-Fab complexes

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12 December 2020

Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes

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12 December 2020

In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease

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12 December 2020

In vitro activity of pleconaril and AG7088 against selected serotypes and clinical isolates of human rhinoviruses

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12 December 2020

The human antimicrobial and chemotactic peptides LL-37 and alpha-defensins are expressed by specific lymphocyte and monocyte populations

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12 December 2020

Pharmacokinetics and safety of an antirhinoviral agent, ruprintrivir, in healthy volunteers

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12 December 2020

Antimicrobial peptides of multicellular organisms

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12 December 2020

Frequency, severity, and duration of rhinovirus infections in asthmatic and non-asthmatic individuals: a longitudinal cohort study.

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12 December 2020

Hemorrhagic fever viruses as biological weapons: medical and public health management

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12 December 2020

Oral pleconaril treatment of picornavirus-associated viral respiratory illness in adults: efficacy and tolerability in phase II clinical trials.

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12 December 2020

Deficiency of antibacterial peptides in patients with morbus Kostmann: an observation study.

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12 December 2020

Efficacy and safety of oral pleconaril for treatment of colds due to picornaviruses in adults: results of 2 double-blind, randomized, placebo-controlled trials

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12 December 2020

Regulation of 25-hydroxyvitamin D3-1 alpha-hydroxylase and production of 1 alpha,25-dihydroxyvitamin D3 by human dendritic cells

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12 December 2020

Virus interference. I. The interferon

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12 December 2020

Human rhinovirus capsid dynamics is controlled by canyon flexibility

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12 December 2020

Phase II, randomized, double-blind, placebo-controlled studies of ruprintrivir nasal spray 2-percent suspension for prevention and treatment of experimentally induced rhinovirus colds in healthy volunteers

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12 December 2020

Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum

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12 December 2020

VP1 sequencing of all human rhinovirus serotypes: insights into genus phylogeny and susceptibility to antiviral capsid-binding compounds

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12 December 2020

Involvement of toll-like receptor 3 in the immune response of lung epithelial cells to double-stranded RNA and influenza A virus

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12 December 2020

Conservation of amino acids in human rhinovirus 3C protease correlates with broad-spectrum antiviral activity of rupintrivir, a novel human rhinovirus 3C protease inhibitor.

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12 December 2020

Novel [(biphenyloxy)propyl]isoxazole derivatives for inhibition of human rhinovirus 2 and coxsackievirus B3 replication

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12 December 2020

Asthmatic bronchial epithelial cells have a deficient innate immune response to infection with rhinovirus

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12 December 2020

2-Ethoxybenzoxazole as a bioisosteric replacement of an ethyl benzoate group in a human rhinovirus (HRV) capsid binder

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12 December 2020

Cathelicidin mediates innate intestinal defense against colonization with epithelial adherent bacterial pathogens.

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12 December 2020

Ribavirin in the treatment of hepatitis C.

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12 December 2020

Human cathelicidin (LL-37), a multifunctional peptide, is expressed by ocular surface epithelia and has potent antibacterial and antiviral activity

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12 December 2020

Activity and regulation of alpha interferon in respiratory syncytial virus and human metapneumovirus experimental infections

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12 December 2020

Insights into the genetic basis for natural phenotypic resistance of human rhinoviruses to pleconaril

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12 December 2020

Relationship of pleconaril susceptibility and clinical outcomes in treatment of common colds caused by rhinoviruses

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12 December 2020

Infections and Airway Inflammation in Chronic Obstructive Pulmonary Disease Severe Exacerbations

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12 December 2020

Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response

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12 December 2020

The antimicrobial peptide cathelicidin protects the urinary tract against invasive bacterial infection

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12 December 2020

Immunomodulatory properties of defensins and cathelicidins

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12 December 2020

Chronic rhinoviral infection in lung transplant recipients.

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12 December 2020

Development of potent inhibitors of the coxsackievirus 3C protease

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12 December 2020

The role of complement and Toll-like receptors in organ transplantation

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12 December 2020

In vitro resistance study of rupintrivir, a novel inhibitor of human rhinovirus 3C protease

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12 December 2020

Distinct RIG-I and MDA5 Signaling by RNA Viruses in Innate Immunity

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12 December 2020

Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

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12 December 2020

TLR3: interferon induction by double-stranded RNA including poly(I:C).

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12 December 2020

The management of coronavirus infections with particular reference to SARS.

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12 December 2020

Length-dependent recognition of double-stranded ribonucleic acids by retinoic acid-inducible gene-I and melanoma differentiation-associated gene 5

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12 December 2020

Rhinovirus disrupts the barrier function of polarized airway epithelial cells

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12 December 2020

Iota-Carrageenan is a potent inhibitor of rhinovirus infection

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12 December 2020

Respiratory epithelial cells convert inactive vitamin D to its active form: potential effects on host defense

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12 December 2020

Viral evasion and subversion of pattern-recognition receptor signalling

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12 December 2020

Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection

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12 December 2020

A TLR3 ligand that exhibits potent inhibition of influenza virus replication and has strong adjuvant activity has the potential for dual applications in an influenza pandemic.

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12 December 2020

Activation of toll-like receptor signaling pathway for protection against influenza virus infection

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12 December 2020

Antibodies to the buried N terminus of rhinovirus VP4 exhibit cross-serotypic neutralization

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12 December 2020

Evasion by stealth: inefficient immune activation underlies poor T cell response and severe disease in SARS-CoV-infected mice

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12 December 2020

Role of double-stranded RNA pattern recognition receptors in rhinovirus-induced airway epithelial cell responses

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12 December 2020

The human cathelicidin LL-37 preferentially promotes apoptosis of infected airway epithelium

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12 December 2020

Intranasal Poly-IC treatment exacerbates tuberculosis in mice through the pulmonary recruitment of a pathogen-permissive monocyte/macrophage population

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12 December 2020

Analysis of the complete genome sequences of human rhinovirus

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12 December 2020

Flagellin stimulates protective lung mucosal immunity: role of cathelicidin-related antimicrobial peptide

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12 December 2020

Experimental rhinovirus infection as a human model of chronic obstructive pulmonary disease exacerbation

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12 December 2020

Co-ordinated role of TLR3, RIG-I and MDA5 in the innate response to rhinovirus in bronchial epithelium

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12 December 2020

Human rhinovirus recognition in non-immune cells is mediated by Toll-like receptors and MDA-5, which trigger a synergetic pro-inflammatory immune response

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12 December 2020

Exogenous IFN-β has antiviral and anti-inflammatory properties in primary bronchial epithelial cells from asthmatic subjects exposed to rhinovirus.

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12 December 2020

Towards the design of combination therapy for the treatment of enterovirus infections

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12 December 2020

Natural and synthetic cathelicidin peptides with anti-microbial and anti-biofilm activity against Staphylococcus aureus

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12 December 2020

Rhinoviruses, allergic inflammation, and asthma

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12 December 2020

Enterovirus 71 and Coxsackievirus A16 3C Proteases: Binding to Rupintrivir and Their Substrates and Anti-Hand, Foot, and Mouth Disease Virus Drug Design

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12 December 2020

Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37

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12 December 2020

The toll-like receptor 3-mediated antiviral response is important for protection against poliovirus infection in poliovirus receptor transgenic mice

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12 December 2020

Poly I:C enhances susceptibility to secondary pulmonary infections by gram-positive bacteria

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12 December 2020

The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins

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12 December 2020

Rhinovirus-associated wheeze during infancy and asthma development

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12 December 2020

Interferon-β induces a long-lasting antiviral state in human respiratory epithelial cells

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12 December 2020

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12 December 2020

Oxysterol-binding protein family I is the target of minor enviroxime-like compounds.

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12 December 2020

Cationic host defence peptides: potential as antiviral therapeutics

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12 December 2020

Phosphatidylinositol 4-kinase III beta is essential for replication of human rhinovirus and its inhibition causes a lethal phenotype in vivo

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12 December 2020

Design, synthesis and biological evaluation of novel aminothiazoles as antiviral compounds acting against human rhinovirus

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12 December 2020

An anti-human ICAM-1 antibody inhibits rhinovirus-induced exacerbations of lung inflammation.

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12 December 2020

The human cathelicidin LL-37 has antiviral activity against respiratory syncytial virus.

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12 December 2020

Effect of exogenous interferons on rhinovirus replication and airway inflammatory responses

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12 December 2020

Little peptide, big effects: the role of LL-37 in inflammation and autoimmune disease

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12 December 2020

Antiviral potential of cathelicidins

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12 December 2020

Multiple classes of antiviral agents exhibit in vitro activity against human rhinovirus type C

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12 December 2020

Effects of vitamin D on airway epithelial cell morphology and rhinovirus replication

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12 December 2020

Treatment of persistent rhinovirus infection with pegylated interferon α2a and ribavirin in patients with hypogammaglobulinemia.

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12 December 2020

Efficacy of IFN-λ1 to protect human airway epithelial cells against human rhinovirus 1B infection

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12 December 2020

An Orally Available 3-Ethoxybenzisoxazole Capsid Binder with Clinical Activity against Human Rhinovirus

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12 December 2020

Carrageenan nasal spray in virus confirmed common cold: individual patient data analysis of two randomized controlled trials

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12 December 2020

Interferon induction by RNA viruses and antagonism by viral pathogens

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12 December 2020

Rhinovirus uses a phosphatidylinositol 4-phosphate/cholesterol counter-current for the formation of replication compartments at the ER-Golgi interface.

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12 December 2020

Itraconazole inhibits enterovirus replication by targeting the oxysterol-binding protein

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12 December 2020

Vitamin D status and acute respiratory infection: cross sectional results from the United States National Health and Nutrition Examination Survey, 2001-2006.

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12 December 2020

Challenges in developing a cross-serotype rhinovirus vaccine.

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12 December 2020

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12 December 2020

Modulation of the immune response to respiratory viruses by vitamin D.

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12 December 2020

In vitro characterisation of a pleconaril/pirodavir-like compound with potent activity against rhinoviruses.

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12 December 2020

Nasal Levels of Antimicrobial Peptides in Allergic Asthma Patients and Healthy Controls: Differences and Effect of a Short 1,25(OH)2 Vitamin D3 Treatment

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12 December 2020

Vitamin D represses rhinovirus replication in cystic fibrosis cells by inducing LL-37.

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12 December 2020

Cathelicidins Have Direct Antiviral Activity against Respiratory Syncytial Virus In Vitro and Protective Function In Vivo in Mice and Humans

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12 December 2020

Therapeutic and prophylactic activity of itraconazole against human rhinovirus infection in a murine model

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12 December 2020

Development of intranasal nanovehicles of itraconazole and their immunological activities for the therapy of rhinovirus infection.

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12 December 2020

Susceptibilities of enterovirus D68, enterovirus 71, and rhinovirus 87 strains to various antiviral compounds

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12 December 2020

Design and structure-activity relationships of novel inhibitors of human rhinovirus 3C protease

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12 December 2020

Approved Antiviral Drugs over the Past 50 Years

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12 December 2020

A review of treatment modalities for Middle East Respiratory Syndrome

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12 December 2020

Vitamin D increases the antiviral activity of bronchial epithelial cells in vitro.

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12 December 2020

The conserved N-terminus of human rhinovirus capsid protein VP4 contains membrane pore-forming activity and is a target for neutralizing antibodies

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12 December 2020

PLA2G16 represents a switch between entry and clearance of Picornaviridae

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12 December 2020

Uncovering oxysterol-binding protein (OSBP) as a target of the anti-enteroviral compound TTP-8307.

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12 December 2020

Antiviral therapy and prevention against hantavirus infections

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12 December 2020

Vitamin D supplementation to prevent acute respiratory tract infections: systematic review and meta-analysis of individual participant data.

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12 December 2020

Investigation of the Role of Protein Kinase D in Human Rhinovirus Replication

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12 December 2020

Proinflammatory Cytokines Impair Vitamin D-Induced Host Defense in Cultured Airway Epithelial Cells

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12 December 2020

In-vitro effect of human cathelicidin antimicrobial peptide LL-37 on dengue virus type 2.

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12 December 2020

Update in the treatment of non-influenza respiratory virus infection in solid organ transplant recipients.

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12 December 2020

Global epidemiology of non-influenza RNA respiratory viruses: data gaps and a growing need for surveillance

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12 December 2020

Broad-spectrum inhibition of common respiratory RNA viruses by a pyrimidine synthesis inhibitor with involvement of the host antiviral response

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12 December 2020

A Novel Series of Highly Potent Small Molecule Inhibitors of Rhinovirus Replication.

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12 December 2020

Recurrent rhinovirus infections in a child with inherited MDA5 deficiency.

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12 December 2020

Antibody-induced uncoating of human rhinovirus B14.

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12 December 2020

Cathelicidins display conserved direct antiviral activity towards rhinovirus

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12 December 2020

Carbon Nanoparticles Inhibit the Antimicrobial Activities of the Human Cathelicidin LL-37 through Structural Alteration.

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12 December 2020

Broad-spectrum non-toxic antiviral nanoparticles with a virucidal inhibition mechanism

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12 December 2020

Antibody therapies for the prevention and treatment of viral infections.

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12 December 2020

Comparative effectiveness of aerosolized versus oral ribavirin for the treatment of respiratory syncytial virus infections: A single-center retrospective cohort study and review of the literature.

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12 December 2020

Fragment-derived inhibitors of human N-myristoyltransferase block capsid assembly and replication of the common cold virus.

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12 December 2020