C-X-C motif chemokine receptor 3 (Q655541)

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mammalian protein found in Homo sapiens

Mig receptor
G protein-coupled receptor 9
chemokine (C-X-C motif) receptor 3
CXCR3
IP-10 receptor
chemokine receptor 3
interferon-inducible protein 10 receptor
CKR-L2
C-X-C chemokine receptor type 3

Language	Label	Description	Also known as
English	C-X-C motif chemokine receptor 3	mammalian protein found in Homo sapiens	Mig receptor G protein-coupled receptor 9 chemokine (C-X-C motif) receptor 3 CXCR3 IP-10 receptor chemokine receptor 3 interferon-inducible protein 10 receptor CKR-L2 C-X-C chemokine receptor type 3

Statements

1 reference

13 November 2019

UniProt protein ID

CXC chemokine receptor 3

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49682

GPCR, rhodopsin-like, 7TM, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

C-X-C chemokine binding

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

signal transducer activity

determination method

1 reference

24 April 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

chemokine binding

determination method

1 reference

21 June 2018

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

protein binding

determination method

1 reference

21 June 2018

Widespread Expansion of Protein Interaction Capabilities by Alternative Splicing

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

signaling receptor activity

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

C-C chemokine receptor activity

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

C-C chemokine binding

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

determination method

1 reference

8 April 2019

IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

integral component of plasma membrane

determination method

1 reference

8 April 2019

Chemokine receptor specific for IP10 and mig: structure, function, and expression in activated T-lymphocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

external side of plasma membrane

determination method

1 reference

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

plasma membrane

determination method

5 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

21 June 2018

Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

intracellular anatomical structure

determination method

1 reference

21 June 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

plasma membrane

determination method

4 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

8 April 2019

Human intestinal lamina propria and intraepithelial lymphocytes express receptors specific for chemokines induced by inflammation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

biological process

negative regulation of execution phase of apoptosis

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

positive regulation of execution phase of apoptosis

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

T cell chemotaxis

determination method

1 reference

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

chemokine-mediated signaling pathway

determination method

1 reference

8 April 2019

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

positive regulation of release of sequestered calcium ion into cytosol

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

positive regulation of cAMP-mediated signaling

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

regulation of leukocyte migration

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

positive regulation of angiogenesis

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

negative regulation of endothelial cell proliferation

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

cell surface receptor signaling pathway

determination method

1 reference

8 April 2019

Human B cell-attracting chemokine 1 (BCA-1; CXCL13) is an agonist for the human CXCR3 receptor

British Heart Foundation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

positive regulation of chemotaxis

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

positive regulation of cell population proliferation

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

chemokine (C-C motif) ligand 11 production

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

negative regulation of angiogenesis

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

inflammatory response

determination method

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

calcium-mediated signaling

determination method

1 reference

21 June 2018

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

positive regulation of transcription by RNA polymerase II

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

signal transduction

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

apoptotic process

determination method

1 reference

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

determination method

3 references

21 June 2018

CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

G protein-coupled receptor signaling pathway

determination method

4 references

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

21 June 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

21 June 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

adenylate cyclase-activating G protein-coupled receptor signaling pathway

determination method

1 reference

21 June 2018

An alternatively spliced variant of CXCR3 mediates the inhibition of endothelial cell growth induced by IP-10, Mig, and I-TAC, and acts as functional receptor for platelet factor 4

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P49682&geneProductId=UniProtKB:P49682

determination method

determination method

4 references

8 April 2019

CXCR3 expression and activation of eosinophils: role of IFN-gamma-inducible protein-10 and monokine induced by IFN-gamma

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

8 April 2019

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

immune response

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

positive regulation of cytosolic calcium ion concentration

determination method

3 references

8 April 2019

IL-4 enhances keratinocyte expression of CXCR3 agonistic chemokines

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

8 April 2019

Ensembl genome database project

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

cell chemotaxis

determination method

1 reference

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

regulation of cell adhesion

determination method

1 reference

8 April 2019

Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4.

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P49682

determination method

Gene Atlas image

PBB GE CXCR3 207681 at fs.png
732 × 530; 11 KB

0 references

http://purl.uniprot.org/uniprot/P49682

1 reference

Identifiers.org

GPCR, rhodopsin-like, 7TM

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P49682

Identifiers

RefSeq protein ID

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000362795

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362795

ENSP00000362797

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000362797

1 reference

Freebase Data Dumps

publication date

28 October 2013

Microsoft Academic ID

0 references

1 reference

26 January 2022

https://docs.openalex.org/download-snapshot/snapshot-data-format

Sitelinks

Wikipedia(7 entries)

dewiki CXCR3
enwiki CXCR3
frwiki CXCR3
jawiki CXCR3
ruwiki CXCR3
ukwiki CXCR3
zhwiki CXCR3

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Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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