Glutamate metabotropic receptor 7 (Q6590338)

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mammalian protein found in Homo sapiens

• glutamate receptor, metabotropic 7
• GRM7
• protein phosphatase 1, regulatory subunit 87
• metabotropic glutamate receptor 7

edit

Language	Label	Description	Also known as
English	Glutamate metabotropic receptor 7	mammalian protein found in Homo sapiens	glutamate receptor, metabotropic 7 GRM7 protein phosphatase 1, regulatory subunit 87 metabotropic glutamate receptor 7

Statements

instance of

protein

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q14831

part of

Periplasmic binding protein-like I

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q14831

GPCR, family 3, metabotropic glutamate receptor 7

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q14831

GPCR, family 3, nine cysteines domain superfamily

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q14831

Receptor, ligand binding region, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR family 3, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 3, nine cysteines domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

GPCR, family 3, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

found in taxon

Homo sapiens

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q14831

encoded by

GRM7

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q14831

molecular function

glutamate receptor activity

determination method

IDA

1 reference

retrieved

27 March 2018

stated in

Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14831&geneProductId=UniProtKB:Q14831

determination method

IDA

calcium ion binding

determination method

IDA

1 reference

retrieved

27 March 2018

stated in

Increases in intracellular calcium triggered by channelrhodopsin-2 potentiate the response of metabotropic glutamate receptor mGluR7

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14831&geneProductId=UniProtKB:Q14831

determination method

IDA

PDZ domain binding

determination method

NAS

1 reference

retrieved

27 March 2018

stated in

Characterization of three novel isoforms of the metabotrobic glutamate receptor 7 (GRM7)

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14831&geneProductId=UniProtKB:Q14831

determination method

NAS

serine binding

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

A novel splice variant of a metabotropic glutamate receptor, human mGluR7b

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

G protein-coupled receptor activity

determination method

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

group III metabotropic glutamate receptor activity

determination method

IDA

2 references

retrieved

8 April 2019

stated in

A novel splice variant of a metabotropic glutamate receptor, human mGluR7b

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

retrieved

8 April 2019

stated in

Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

adenylate cyclase inhibitor activity

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

signal transducer activity

determination method

IEA

1 reference

retrieved

27 March 2018

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14831&geneProductId=UniProtKB:Q14831

determination method

IEA

glutamate binding

determination method

IDA

1 reference

retrieved

27 March 2018

stated in

A novel splice variant of a metabotropic glutamate receptor, human mGluR7b

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14831&geneProductId=UniProtKB:Q14831

determination method

IDA

calcium channel regulator activity

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IBA

glutamate receptor activity

determination method

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IBA

cell component

integral component of membrane

determination method

IDA

IEA

3 references

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

retrieved

8 April 2019

stated in

Expression of metabotropic glutamate receptors in rat meningeal and brain microvasculature and choroid plexus

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

postsynaptic membrane

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

ISS

membrane

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

receptor complex

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Structural basis for endosomal trafficking of diverse transmembrane cargos by PX-FERM proteins

GOA

curator

Mouse Genome Informatics

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

plasma membrane

determination method

TAS

IEA

2 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

integral component of plasma membrane

determination method

IBA

NAS

2 references

retrieved

8 April 2019

stated in

Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

NAS

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IBA

dendritic shaft

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

ISS

presynaptic active zone

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

ISS

axon

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

ISS

dendrite

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Immunohistochemical localisation of mGluR7 protein in the rodent and human cerebellar cortex using subtype specific antibodies

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

cell cortex

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Immunohistochemical localisation of mGluR7 protein in the rodent and human cerebellar cortex using subtype specific antibodies

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

asymmetric synapse

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

ISS

presynaptic membrane

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IBA

biological process

negative regulation of glutamate secretion

determination method

ISS

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

ISS

response to stimulus

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

hearing

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

GRM7 variants confer susceptibility to age-related hearing impairment

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IMP

behavioral fear response

determination method

IMP

1 reference

retrieved

8 April 2019

stated in

Lack of polymorphism in genes encoding mGluR 7, mGluR 8, GABA(A) receptor alfa-6 subunit and nociceptin/orphanin FQ receptor and panic disorder

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IMP

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

determination method

IDA

1 reference

retrieved

27 March 2018

stated in

Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14831&geneProductId=UniProtKB:Q14831

determination method

IDA

signal transduction

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

regulation of cyclase activity

determination method

IEA

1 reference

retrieved

8 April 2019

stated in

GOA

curator

Gene Ontology Consortium

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

regulation of synaptic transmission, glutamatergic

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IBA

chemical synaptic transmission

determination method

IDA

1 reference

retrieved

8 April 2019

stated in

Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

G protein-coupled receptor signaling pathway

determination method

IEA

TAS

3 references

retrieved

8 April 2019

stated in

GOA

curator

Reactome

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

TAS

retrieved

8 April 2019

stated in

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

retrieved

8 April 2019

stated in

GOA

curator

InterPro

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IEA

adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway

determination method

IDA

1 reference

retrieved

27 March 2018

stated in

A novel splice variant of a metabotropic glutamate receptor, human mGluR7b

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?protein=Q14831&geneProductId=UniProtKB:Q14831

determination method

IDA

adenylate cyclase-inhibiting G protein-coupled glutamate receptor signaling pathway

determination method

IBA

IDA

2 references

retrieved

8 April 2019

stated in

Group III human metabotropic glutamate receptors 4, 7 and 8: molecular cloning, functional expression, and comparison of pharmacological properties in RGT cells

GOA

curator

UniProt

UniProt protein ID

Q14831

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IDA

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IBA

G protein-coupled glutamate receptor signaling pathway

determination method

IBA

1 reference

retrieved

8 April 2019

stated in

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

GOA

curator

GO Central

reference URL

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q14831

determination method

IBA

physically interacts with

L-AP4

has use

agonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

1410

language of work or name

English

retrieved

17 August 2016

DCG-IV

has use

antagonist

1 reference

stated in

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

1377

language of work or name

English

retrieved

17 August 2016

Gene Atlas image

PBB GE GRM7 217008 s at fs.png
732 × 530; 12 KB

0 references

has part(s)

GPCR, family 3, nine cysteines domain

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q14831

Receptor, ligand binding region

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q14831

GPCR, family 3, conserved site

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q14831

GPCR family 3, C-terminal

1 reference

stated in

InterPro Release 71.0

reference URL

http://www.ebi.ac.uk/interpro/protein/Q14831

Identifiers

RefSeq protein ID

NP_000835

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2917

NP_870989

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2917

XP_016861761

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2917

XP_016861762

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2917

XP_024309260

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2917

XP_024309261

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2917

XP_024309262

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2917

XP_024309263

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2917

XP_024309265

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2917

XP_024309266

1 reference

stated in

NCBI Gene

retrieved

30 May 2020

Entrez Gene ID

2917

UniProt protein ID

Q14831

1 reference

stated in

UniProt

retrieved

13 November 2019

UniProt protein ID

Q14831

Ensembl protein ID

ENSP00000350348

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000350348

ENSP00000373986

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000373986

ENSP00000373987

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000373987

ENSP00000417536

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000417536

ENSP00000419835

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000419835

ENSP00000384585

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000384585

ENSP00000393799

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000393799

ENSP00000395035

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000395035

ENSP00000404161

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000404161

ENSP00000405194

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000405194

ENSP00000412329

1 reference

stated in

Ensembl Release 99

Ensembl protein ID

ENSP00000412329

Freebase ID

/m/03d4qhn

0 references

Microsoft Academic ID

87247309

0 references

OpenAlex ID

C87247309

1 reference

stated in

OpenAlex

retrieved

26 January 2022

reference URL

https://docs.openalex.org/download-snapshot/snapshot-data-format

PDB structure ID

3MQ4

1 reference

stated in

UniProt

UniProt protein ID

Q14831

retrieved

9 August 2016

language of work or name

English

5C5C

1 reference

stated in

UniProt

UniProt protein ID

Q14831

retrieved

9 August 2016

language of work or name

English

 

Sitelinks

Wikipedia(7 entries)

edit

• cywiki GRM7
• dewiki Metabotroper Glutamatrezeptor 7
• enwiki Metabotropic glutamate receptor 7
• ptwiki Receptor metabotrópico de glutamato 7
• shwiki Metabotropni glutamatni receptor 7
• srwiki Metabotropni glutamatni receptor 7
• ukwiki GRM7

Wikibooks(0 entries)

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Wikinews(0 entries)

edit

Wikiquote(0 entries)

edit

Wikisource(0 entries)

edit

Wikiversity(0 entries)

edit

Wikivoyage(0 entries)

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Wiktionary(0 entries)

edit

Multilingual sites(0 entries)

edit

Retrieved from "https://www.wikidata.org/w/index.php?title=Q6590338&oldid=2174112425"