Antinociceptive and substance P antagonistic effects of intrathecally injected spantide II in rat: no signs of motor impairment or neurotoxicity (Q67668050)

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scientific article published on 01 June 1990

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English	Antinociceptive and substance P antagonistic effects of intrathecally injected spantide II in rat: no signs of motor impairment or neurotoxicity	scientific article published on 01 June 1990

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scholarly article

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16 September 2019

Antinociceptive and substance P antagonistic effects of intrathecally injected spantide II in rat: no signs of motor impairment or neurotoxicity (English)

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16 September 2019

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based on heuristic

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toxic encephalopathy

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based on heuristic

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10.1016/0167-0115(90)90104-5

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10.1016/0167-0115(90)90104-5

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1 November 2022

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Z. Wiesenfeld-Hallin

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X. J. Xu

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1 November 2022

K. Kristensson

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1 November 2022

R. Håkanson

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1 November 2022

D. M. Feng

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1 November 2022

K. Folkers

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1 November 2022

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1 November 2022

publication date

1 June 1990

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16 September 2019

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1 November 2022

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10.1016/0167-0115(90)90104-5

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Regulatory Peptides

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16 September 2019

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16 September 2019

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16 September 2019

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Regional distribution of substance P in the spinal cord and nerve roots of the cat and the effect of dorsal root section

2

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Experimental immunohistochemical studies on the localization and distribution of substance P in cat primary sensory neurons

3

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Distribution of substance P-like immunoreactivity in the central nervous system of the rat—I. Cell bodies and nerve terminals

4

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Release of substance P-like immunoreactivity from isolated spinal cord of newborn rat

6

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Identification by high-performance liquid chromatography of immunoreactive substance P released from isolated rat spinal cord

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In vivo release of substance P in cat dorsal horn studied with microdialysis

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Effects of substance P on functionally identified units in cat spinal cord

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Effect of substance P in cat dorsal horn neurones activated by noxious stimuli

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Intrathecal substance P elicits a caudally-directed biting and scratching behavior in mice

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Intrathecal substance P and somatostatin in rats: Behaviors indicative of sensation

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Neurotransmitter candidates of somatosensory primary afferent fibres

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Chemical design of antagonists of substance P

16

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A synthetic peptide as an antagonist of substance P

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Inhibition of antidromic and substance P-induced vasodilatation by a substance P antagonist

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A specific substance P antagonist blocks smooth muscle contractions induced by non-cholinergic, non-adrenergic nerve stimulation

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Design and Synthesis of Effective Antagonists of Substance P

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Synthesis and biological activities of substance P antagonists.

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Substance P antagonists active in vitro and in vivo.

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The mechanism of action of a substance P antagonist (D-Pro2, D-Trp7,9)-SP.

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Biological evaluation of substance P antagonists

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Sensory and Motor Functions of Spinal Cord Substance P

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Substance p anatogue blocks sp-induced facilitation of a spinal nociceptive reflex

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27

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Effects of substance P analogues on spinal dorsal horn neurons

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Lntrathecal (D-Pro2, D-Trp7,9)-SP elicits hypoalgesia and motor blockade in the rat and antagonizes noxious responses induced by substance P

29

1 reference

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Analgesic effect of antagonists of substance P

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Antinociceptive and neurotoxic actions of substance P analogues in the rat's spinal cord after intrathecal administration

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The behavioural effects of intrathecally administered [d-PRO2,d-TRP7,9]-substance P, an analogue with presumed antagonist actions, in the rat

33

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Intrathecal substance P analogue causes motor dysfunction in the rat

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Evaluation of (D-Pro2, D-Trp7,9)-substance P as an antagonist of substance P responses in the rat central nervous system.

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D-Arg1, D-Trp7,9, Leu11-substance P (spantide) does not antagonize substance P-induced hyperexcitability of the nociceptive flexion withdrawal reflex in the rat

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Immunohistochemical evidence for a “neurotoxic” action of (D-Pro2, D-Trp7,9)-substance P, an analogue with substance P antagonistic activity

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Identifiers

10.1016/0167-0115(90)90104-5

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Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1697080%20AND%20SRC:MED&resulttype=core&format=json

16 September 2019

PubMed publication ID

1 reference

Europe PubMed Central

PubMed publication ID

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:1697080%20AND%20SRC:MED&resulttype=core&format=json

16 September 2019

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