Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a "redox cycling" mechanism in MPTP neurotoxicity (Q68830483)

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27 September 2019

title

Model study on the bioreduction of paraquat, MPP+, and analogs. Evidence against a "redox cycling" mechanism in MPTP neurotoxicity (English)

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27 September 2019

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D M Frank

1

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27 September 2019

P K Arora

series ordinal

2

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27 September 2019

J L Blumer

series ordinal

3

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27 September 2019

L M Sayre

series ordinal

4

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27 September 2019

language of work or name

English

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publication date

1 September 1987

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Biochemical and Biophysical Research Communications

27 September 2019

published in

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27 September 2019

volume

147

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27 September 2019

issue

3

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27 September 2019

page(s)

1095-1104

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Chronic Parkinsonism in humans due to a product of meperidine-analog synthesis

27 September 2019

cites work

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

The pharmacology of the parkinsonian syndrome producing neurotoxin MPTP (1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine) and structurally related compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Metabolism of the neurotoxic tertiary amine, MPTP, by brain monoamine oxidase.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Intraneuronal generation of a pyridinium metabolite may cause drug-induced parkinsonism.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

1-Methyl-4-phenylpyridine (MPP+) is toxic to mesencephalic dopamine neurons in culture

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

1-Methyl-4-phenylpyridinium (MPP+) but not 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) selectively destroys dopaminergic neurons in cultures of dissociated rat mesencephalic neurons.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and 1-methyl-4-phenylpyridine (MPP+) cause rapid ATP depletion in isolated hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Dopaminergic toxicity after the stereotaxic administration of the 1-methyl-4-phenylpyridinium ion (MPP+) to rats.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Comparative toxicity of MPTP, MPP+ and 3,3-dimethyl-MPDP+ to dopaminergic neurons of the rat substantia nigra

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

1-methyl-4-phenylpyridine is neurotoxic to the nigrostriatal dopamine pathway.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Bipyridylium quaternary salts and related compounds. V. Pulse radiolysis studies of the reaction of paraquat radical with oxygen. Implications for the mode of action of bipyridyl herbicides

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

The action of paraquat and diquat on the respiration of liver cell fractions

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Paraquat-induced alterations of phospholipids and GSSG-release in the isolated perfused rat liver, and the effect of SOD-active copper complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

The relevance of pentose phosphate pathway stimulation in rat lung to the mechanism of paraquat toxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Toxic drug effects associated with oxygen metabolism: redox cycling and lipid peroxidation

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Differences in the metabolism of MPTP in the rodent and primate parallel differences in sensitivity to its neurotoxic effects.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

1-Methyl-4-phenylpyridine (MPP+) induces oxidative stress in the rodent.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

A rapid one-step purification of NADPH-cytochrome c (P-450) reductase from rat liver microsomes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

The use of acetylated ferricytochrome C for the detection of superoxide radicals produced in biological membranes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Generation of superoxide anion as a source of hydrogen peroxide in a reconstituted monooxygenase system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

The role of catalytic superoxide formation in the O2 inhibition of nitroreductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

A mechanism of paraquat toxicity in mice and rats

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Superoxide- and singlet oxygen-catalyzed lipid peroxidation as a possible mechanism for paraquat (methyl viologen) toxicity.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Studies on the mechanism of the lung toxicity of paraquat: comparison of tissue distribution and some biochemical parameters in rats and rabbits

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Role of redox cycling and lipid peroxidation in bipyridyl herbicide cytotoxicity. Studies with a compromised isolated hepatocyte model system

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

THE MECHANISM OF AEROBIC OXIDASE REACTION CATALYZED BY PEROXIDASE

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Control of the generation and reactions of free radicals in biological systems by kinetic and thermodynamic factors

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Nitroimidazoles as anaerobic electron acceptors for xanthine oxidase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Inhibition of microsomal aldrin epoxidation by diquat and several related bipyridvlium compounds

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Formation of superoxide and hydroxyl radicals from 1-methyl-4-phenylpyridinium ion (MPP+): reductive activation by NADPH cytochrome P-450 reductase

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Selectivity of the parkinsonian neurotoxin MPTP: toxic metabolite MPP+ binds to neuromelanin.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Characterization of the binding of N-methyl-4-phenylpyridine, the toxic metabolite of the parkinsonian neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine, to neuromelanin

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Electron spin resonance studies of chloroquine-melanin complexes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Mechanism of dismutation of superoxide produced during autoxidation of melanin pigments

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Partial protection from the dopaminergic neurotoxin N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine by four different antioxidants in the mouse.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Protection against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity by the antioxidant ascorbic acid.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Ascorbic acid reduces the dopamine depletion induced by MPTP.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Ascorbic acid reduces the dopamine depletion induced by methamphetamine and the 1-methyl-4-phenyl pyridinium ion.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in mice is enhanced by pretreatment with diethyldithiocarbamate.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Systemic administration of antioxidants does not protect mice against the dopaminergic neurotoxicity of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP).

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Depletion of glutathione in brainstem of mice caused by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine is prevented by antioxidant pretreatment.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Effect of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on levels of glutathione in the extrapyramidal system of the mouse.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Manipulation of glutathione contents fails to alter dopaminergic nigrostriatal neurotoxicity of N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the mouse.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Comparative studies on the mechanisms of paraquat and 1-methyl-4-phenylpyridine (MPP+) cytotoxicity

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Studies on the mechanism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine cytotoxicity in isolated hepatocytes

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine.

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Uptake of the neurotoxin 1-methyl-4-phenylpyridine (MPP+) by mitochondria and its relation to the inhibition of the mitochondrial oxidation of NAD+-linked substrates by MPP+

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

Effects of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine and its metabolite 1-methyl-4-phenylpyridine on acetylcholine synthesis in synaptosomes from rat forebrain

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

MPTP, MPP+ and mitochondrial function

7 January 2021

1 reference

https://api.crossref.org/works/10.1016%2FS0006-291X%2887%2980183-3

10.1016/S0006-291X(87)80183-3

7 January 2021

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DOI

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https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:3499150%20AND%20SRC:MED&resulttype=core&format=json

27 September 2019

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