Sodium voltage-gated channel alpha subunit 4 (Q6981557)

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mammalian protein found in Homo sapiens

skeletal muscle voltage-dependent sodium channel type IV alpha subunit
sodium channel protein type 4 subunit alpha
CTC-264K15.6
skeletal muscle sodium channel alpha subunit
voltage-gated sodium channel subunit alpha Nav1.4
SkM1
sodium channel, voltage-gated, type IV, alpha subunit
SCN4A
sodium channel protein skeletal muscle subunit alpha
sodium channel protein type IV subunit alpha

Language	Label	Description	Also known as
English	Sodium voltage-gated channel alpha subunit 4	mammalian protein found in Homo sapiens	skeletal muscle voltage-dependent sodium channel type IV alpha subunit sodium channel protein type 4 subunit alpha CTC-264K15.6 skeletal muscle sodium channel alpha subunit voltage-gated sodium channel subunit alpha Nav1.4 SkM1 sodium channel, voltage-gated, type IV, alpha subunit SCN4A sodium channel protein skeletal muscle subunit alpha sodium channel protein type IV subunit alpha

Statements

1 reference

13 November 2019

UniProt protein ID

Voltage gated sodium channel, alpha-4 subunit, mammalian

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35499

Voltage-dependent channel domain superfamily

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35499

Voltage gated sodium channel

1 reference

Transporter Classification Database ID

2 October 2019

based on heuristic

hierarchical database ID heuristic

Sodium ion transport-associated domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

Ion transport domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

IQ motif, EF-hand binding site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

molecular function

ion channel activity

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

sodium channel activity

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

voltage-gated ion channel activity

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

voltage-gated sodium channel activity

determination method

3 references

10 September 2018

Functional consequences of a domain 1/S6 segment sodium channel mutation associated with painful congenital myotonia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

voltage-gated sodium channel complex

determination method

1 reference

16 July 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

integral component of membrane

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

integral component of plasma membrane

determination method

1 reference

10 September 2018

Identification of a mutation in the gene causing hyperkalemic periodic paralysis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

determination method

2 references

plasma membrane

determination method

1 reference

16 July 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

biological process

regulation of ion transmembrane transport

determination method

1 reference

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

ion transmembrane transport

determination method

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

muscle contraction

determination method

1 reference

10 September 2018

Novel mutations in families with unusual and variable disorders of the skeletal muscle sodium channel

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

membrane depolarization during action potential

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

determination method

2 references

neuronal action potential

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

transmembrane transport

determination method

1 reference

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

sodium ion transport

determination method

3 references

10 September 2018

Functional consequences of a domain 1/S6 segment sodium channel mutation associated with painful congenital myotonia

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

10 September 2018

UniProt protein ID

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

10 September 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

sodium ion transmembrane transport

determination method

1 reference

16 July 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

sodium ion transmembrane transport

determination method

1 reference

10 September 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?protein=P35499&geneProductId=UniProtKB:P35499

determination method

physically interacts with

(RS)-mexiletine

channel blocker

1 reference

IUPHAR/BPS Guide to PHARMACOLOGY

Guide to Pharmacology Ligand ID

language of work or name

17 August 2016

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL861

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201242

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1068

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL29741

dichlorobenzyl alcohol

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3184437

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL2107771

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL3678076

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL79

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL750

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL220492

chloroprocaine hydrochloride

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL944

eslicarbazepine

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL315985

quinidine gluconate

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200437

disopyramide phosphate

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201020

dyclonine hydrochloride

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200478

mepivacaine hydrochloride

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200440

(RS)-mexiletine hydrochloride

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200606

orphenadrine citrate

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200395

procainamide hydrochloride

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL605

propafenone hydrochloride

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1201063

benoxinate hydrochloride

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200654

levobupivacaine hydrochloride

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200749

prilocaine hydrochloride

object has role

channel blocker

1 reference

Open Targets Platform

14 August 2023

https://platform.opentargets.org/drug/CHEMBL1200586

Gene Atlas image

PBB GE SCN4A 206981 at fs.png
732 × 530; 12 KB

0 references

Ion transport domain

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35499

IQ motif, EF-hand binding site

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35499

Sodium ion transport-associated

1 reference

InterPro Release 71.0

http://www.ebi.ac.uk/interpro/protein/P35499

Identifiers

MeSH descriptor ID

0 references

RefSeq protein ID

1 reference

30 May 2020

UniProt protein ID

1 reference

13 November 2019

UniProt protein ID

Ensembl protein ID

ENSP00000396320

1 reference

Ensembl Release 99

Ensembl protein ID

ENSP00000396320

Transporter Classification Database ID

2 references

Transporter Classification database

13 March 2020

Transporter Classification database

29 April 2020

Sitelinks

Wikipedia(0 entries)

Wikibooks(0 entries)

Wikinews(0 entries)

Wikiquote(0 entries)

Wikisource(0 entries)

Wikiversity(0 entries)

Wikivoyage(0 entries)

Wiktionary(0 entries)

Multilingual sites(0 entries)

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