bone morphogenetic protein 4 (Q700001)

Cystine-knot cytokine

1 reference

Transforming growth factor-beta, C-terminal domain, protein family

1 reference

based on heuristic

inferred from protein domain or family

TGF-beta, propeptide family

1 reference

based on heuristic

inferred from protein domain or family

Transforming growth factor beta, conserved site, protein family

1 reference

based on heuristic

inferred from protein domain or family

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

transforming growth factor beta receptor binding

IPI

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

A mammalian serine/threonine kinase receptor specifically binds BMP-2 and BMP-4

growth factor activity

2 references

1 reference

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

7 references

1 January 2018

The daf-4 gene encodes a bone morphogenetic protein receptor controlling C. elegans dauer larva development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Agrin binds BMP2, BMP4 and TGFbeta1

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Targeting of bone morphogenetic protein growth factor complexes to fibrillin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

DIP2 disco-interacting protein 2 homolog A (Drosophila) is a candidate receptor for follistatin-related protein/follistatin-like 1--analysis of their binding with TGF-β superfamily proteins

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

WFIKKN1 and WFIKKN2 bind growth factors TGFβ1, BMP2 and BMP4 but do not inhibit their signalling activity

IntAct protein interaction database

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Functional analysis of bone morphogenetic protein type II receptor mutations underlying primary pulmonary hypertension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

IPI

chemoattractant activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

4 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

endoplasmic reticulum lumen

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Bone morphogenetic protein signaling by hemojuvelin regulates hepcidin expression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

embryonic skeletal system morphogenesis

biological process

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of T cell differentiation in thymus

1 reference

1 January 2018

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

germ cell development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

skeletal system development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

mesenchymal cell differentiation involved in renal system development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

cardiac septum development

1 reference

1 January 2018

Mutations in GATA4, NKX2.5, CRELD1, and BMP4 are infrequently found in patients with congenital cardiac septal defects

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of endothelial cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of immature T cell proliferation in thymus

1 reference

1 January 2018

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

bud elongation involved in lung branching

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

anatomical structure formation involved in morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of cell cycle

1 reference

1 January 2018

Altered growth responses of pulmonary artery smooth muscle cells from patients with primary pulmonary hypertension to transforming growth factor-beta(1) and bone morphogenetic proteins

HUGO Gene Nomenclature Committee

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

mesenchymal to epithelial transition involved in metanephros morphogenesis

1 reference

1 January 2018

BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

monocyte differentiation

1 reference

1 January 2018

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

specification of ureteric bud anterior/posterior symmetry by BMP signaling pathway

blood vessel endothelial cell proliferation involved in sprouting angiogenesis

1 reference

1 January 2018

BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

cranial suture morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

Involvement of FGF and BMP family proteins and VEGF in early human kidney development

mesonephros development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

odontogenesis of dentin-containing tooth

IEP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

telencephalon regionalization

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of chondrocyte differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

blood vessel development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of mitotic nuclear division

1 reference

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

prostate gland morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of ERK1 and ERK2 cascade

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

BMP signaling pathway involved in heart induction

1 reference

1 January 2018

BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of epithelial cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

inner ear receptor cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

mesodermal cell fate determination

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

metanephros development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

type B pancreatic cell development

1 reference

1 January 2018

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of pathway-restricted SMAD protein phosphorylation

1 reference

1 January 2018

BMPER is an endothelial cell regulator and controls bone morphogenetic protein-4-dependent angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

steroid hormone mediated signaling pathway

1 reference

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

mammary gland formation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of collagen biosynthetic process

1 reference

1 January 2018

Noncanonical Wnt-4 signaling enhances bone regeneration of mesenchymal stem cells in craniofacial defects through activation of p38 MAPK

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of myoblast differentiation

1 reference

1 January 2018

Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

common-partner SMAD protein phosphorylation

1 reference

1 January 2018

Tumor suppressor FLCN inhibits tumorigenesis of a FLCN-null renal cancer cell line and regulates expression of key molecules in TGF-beta signaling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

glomerular visceral epithelial cell development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

embryonic digit morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

epithelial-mesenchymal cell signaling

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of thymocyte apoptotic process

1 reference

1 January 2018

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

mesenchymal cell differentiation involved in kidney development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of cell death

1 reference

1 January 2018

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of odontogenesis of dentin-containing tooth

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

mesenchymal cell proliferation involved in ureteric bud development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

smooth muscle cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

lymphoid progenitor cell differentiation

1 reference

1 January 2018

Bone morphogenetic protein 2/4 signaling regulates early thymocyte differentiation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

epithelium development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of transcription, DNA-templated

3 references

1 January 2018

The surface ectoderm is essential for nephric duct formation in intermediate mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

BMP4 induces HO-1 via a Smad-independent, p38MAPK-dependent pathway in pulmonary artery myocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of prostatic bud formation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

telencephalon development

1 reference

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of kidney development

1 reference

1 January 2018

The surface ectoderm is essential for nephric duct formation in intermediate mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

cartilage development

1 reference

1 January 2018

embryonic limb morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of MAP kinase activity

1 reference

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of cartilage development

1 reference

1 January 2018

Novel regulators of bone formation: molecular clones and activities

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

lens induction in camera-type eye

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of neuron differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

branching involved in prostate gland morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of protein import into nucleus

1 reference

1 January 2018

Altered subcellular localization of transcription factor TEAD4 regulates first mammalian cell lineage commitment

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

erythrocyte differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

smoothened signaling pathway

1 reference

1 January 2018

Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

camera-type eye development

IEP

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

secondary heart field specification

1 reference

1 January 2018

BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of phosphorylation

1 reference

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of smooth muscle cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of cell fate commitment

1 reference

1 January 2018

GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of branching involved in prostate gland morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of cartilage development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of epithelial cell proliferation

1 reference

1 January 2018

Bone morphogenetic proteins promote development of fetal pancreas epithelial colonies containing insulin-positive cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

epithelial cell proliferation involved in lung morphogenesis

1 reference

1 January 2018

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of cell proliferation involved in heart morphogenesis

1 reference

1 January 2018

BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of smooth muscle cell proliferation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of morphogenesis of a branching structure

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

BMP signaling pathway

5 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

macrophage differentiation

1 reference

1 January 2018

Monocytic cells derived from human embryonic stem cells and fetal liver share common differentiation pathways and homeostatic functions

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of metanephric comma-shaped body morphogenesis

1 reference

1 January 2018

BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

embryonic skeletal system development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

mesenchymal cell proliferation involved in ureter development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of gene expression

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

embryonic cranial skeleton morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

dorsal/ventral neural tube patterning

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

lung alveolus development

1 reference

1 January 2018

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of protein binding

1 reference

1 January 2018

Rnf165/Ark2C enhances BMP-Smad signaling to mediate motor axon extension

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

anterior/posterior axis specification

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of transcription, DNA-templated

3 references

1 January 2018

Evidence that bone morphogenetic protein 4 has multiple biological functions during kidney and urinary tract development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of epidermal cell differentiation

1 reference

1 January 2018

GDF3 is a BMP inhibitor that can activate Nodal signaling only at very high doses

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

branching morphogenesis of an epithelial tube

1 reference

1 January 2018

BMP-4 affects the differentiation of metanephric mesenchyme and reveals an early anterior-posterior axis of the embryonic kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

specification of animal organ position

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of glomerular mesangial cell proliferation

1 reference

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of smooth muscle cell proliferation

intermediate mesodermal cell differentiation

1 reference

1 January 2018

The surface ectoderm is essential for nephric duct formation in intermediate mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

pulmonary artery endothelial tube morphogenesis

1 reference

1 January 2018

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

pituitary gland development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of cell death

1 reference

1 January 2018

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

bud dilation involved in lung branching

1 reference

1 January 2018

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of cardiac muscle fiber development

1 reference

1 January 2018

BMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of striated muscle tissue development

1 reference

1 January 2018

Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of cell migration

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of branch elongation involved in ureteric bud branching by BMP signaling pathway

BMP signaling pathway involved in nephric duct formation

1 reference

1 January 2018

The surface ectoderm is essential for nephric duct formation in intermediate mesoderm

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of pathway-restricted SMAD protein phosphorylation

5 references

24 April 2018

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

negative regulation of mesenchymal cell proliferation involved in ureter development

1 reference

1 January 2018

Sonic hedgehog regulates proliferation and differentiation of mesenchymal cells in the mouse metanephric kidney

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

cellular response to growth factor stimulus

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of endothelial cell migration

1 reference

1 January 2018

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

multicellular organism development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of metanephric S-shaped body morphogenesis

1 reference

1 January 2018

BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

vasculature development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

embryonic morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

protein localization to nucleus

1 reference

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of apoptotic process

embryonic skeletal joint morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of branching involved in ureteric bud morphogenesis

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Ureteric branching morphogenesis in BMP4 heterozygous mutant mice

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

mesodermal cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

neuron fate commitment

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

forebrain development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

camera-type eye morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of SMAD protein signal transduction

1 reference

1 January 2018

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of glomerulus development

1 reference

1 January 2018

BMPs and BMP receptors in mouse metanephric development: in vivo and in vitro studies

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

embryonic hindlimb morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

outflow tract morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

BMP4 rescues a non-cell-autonomous function of Msx1 in tooth development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of transcription by RNA polymerase II

IGI

3 references

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

24 April 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?protein=P12644&geneProductId=UniProtKB:P12644

epithelial to mesenchymal transition involved in endocardial cushion formation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

cardiac jelly development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

cellular response to BMP stimulus

1 reference

1 January 2018

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of osteoblast differentiation

epithelial tube branching involved in lung morphogenesis

1 reference

1 January 2018

Evidence from normal expression and targeted misexpression that bone morphogenetic protein (Bmp-4) plays a role in mouse embryonic lung morphogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

cardiac muscle cell differentiation

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

apoptotic process involved in endocardial cushion morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

muscular septum morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of transcription by RNA polymerase II

5 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Effect of bone morphogenetic proteins-4, -5 and -6 on DNA synthesis and expression of bone-related proteins in cultured human periodontal ligament cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of bone mineralization

3 references

1 January 2018

Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Endogenous TGF-beta signaling suppresses maturation of osteoblastic mesenchymal cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

cardiac right ventricle morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of pri-miRNA transcription by RNA polymerase II

1 reference

1 January 2018

SMAD proteins control DROSHA-mediated microRNA maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of production of miRNAs involved in gene silencing by miRNA

1 reference

1 January 2018

SMAD proteins control DROSHA-mediated microRNA maturation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

post-translational protein modification

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of gene expression

TAS

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

MicroRNA-363 negatively regulates the left ventricular determining transcription factor HAND1 in human embryonic stem cell-derived cardiomyocytes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of epithelial to mesenchymal transition

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of cardiac neural crest cell migration involved in outflow tract morphogenesis

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of signaling receptor activity

1 reference

1 January 2018

Gene Ontology Consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of pri-miRNA transcription by RNA polymerase II

1 reference

1 January 2018

Bone morphogenetic protein 4 regulates microRNAs miR-494 and miR-126-5p in control of endothelial cell function in angiogenesis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of transcription by RNA polymerase II

4 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Bone morphogenetic proteins (BMPs) as regulators of dorsal forebrain development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

positive regulation of pathway-restricted SMAD protein phosphorylation

6 references

1 January 2018

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Bone morphogenetic protein-4 inhibitor gremlin is overexpressed in idiopathic pulmonary fibrosis

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Endogenous Wnt/beta-catenin signaling is required for cardiac differentiation in human embryonic stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

Repulsive guidance molecule RGMa alters utilization of bone morphogenetic protein (BMP) type II receptors by BMP2 and BMP4

BMP signaling pathway

6 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Hemojuvelin regulates hepcidin expression via a selective subset of BMP ligands and receptors independently of neogenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Dual role of the Smad4/DPC4 tumor suppressor in TGFbeta-inducible transcriptional complexes

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

BMP-2/4 and BMP-6/7 differentially utilize cell surface receptors to induce osteoblastic differentiation of human bone marrow-derived mesenchymal stem cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of apoptotic process

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

negative regulation of apoptotic process

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Regulation of bone morphogenetic protein signalling in human pulmonary vascular development

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

regulation of MAPK cascade

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 reference

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

SMAD protein signal transduction

3 references

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Antagonistic effects of bone morphogenetic protein-4 and -7 on renal mesangial cell proliferation induced by aldosterone through MAPK activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

1 January 2018

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

Immunohistochemical analysis of Sonic hedgehog signalling in normal human urinary tract development

renal system development

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P12644

http://purl.uniprot.org/uniprot/P12644

IEP

Gene Atlas image

PBB GE BMP4 211518 s at fs.png
732 × 530; 11 KB

0 references

exact match

1 reference

Transforming growth factor-beta, C-terminal

Identifiers.org

has part(s)

1 reference

TGF-beta, propeptide

1 reference

Transforming growth factor beta, conserved site

1 reference

inferred by common MeSH mappings on source and on Wikidata

Identifiers

MeSH descriptor ID

D055415

subject named as

Bone Morphogenetic Protein 4

0 references

MeSH tree code

D12.644.276.954.200.400

0 references

D12.776.467.942.200.400

0 references

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference

1 reference