Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (Q7117823)

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mammalian protein found in Homo sapiens
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
  • phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha
  • PIK3CA
  • serine/threonine protein kinase PIK3CA
  • p110alpha
  • phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
  • PI3-kinase p110 subunit alpha
  • ptdIns-3-kinase subunit p110-alpha
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphoinositide-3-kinase catalytic alpha polypeptide
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • 2.7.11.1
  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform
  • PIK3CA protein, human
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Language Label Description Also known as
English
Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
mammalian protein found in Homo sapiens
  • Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
  • phosphatidylinositol 3-kinase, catalytic, 110-KD, alpha
  • PIK3CA
  • serine/threonine protein kinase PIK3CA
  • p110alpha
  • phosphatidylinositol-4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha
  • PI3-kinase p110 subunit alpha
  • ptdIns-3-kinase subunit p110-alpha
  • phosphoinositide-3-kinase, catalytic, alpha polypeptide
  • phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
  • Phosphoinositide-3-kinase catalytic alpha polypeptide
  • phosphatidylinositol 3-kinase, catalytic, alpha polypeptide
  • 2.7.11.1
  • phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit, alpha isoform
  • PIK3CA protein, human

Statements

part of
molecular function
protein binding
determination method
IPI
15 references
retrieved
9 May 2019
stated in
PI3K is negatively regulated by PIK3IP1, a novel p110 interacting protein
GOA
curator
UniProt
UniProt protein ID
P42336
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
FAM83B-mediated activation of PI3K/AKT and MAPK signaling cooperates to promote epithelial cell transformation and resistance to targeted therapies
GOA
curator
UniProt
UniProt protein ID
P42336
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2
GOA
curator
UniProt
UniProt protein ID
P42336
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
Cancer-derived mutations in the regulatory subunit p85alpha of phosphoinositide 3-kinase function through the catalytic subunit p110alpha
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
A frequent kinase domain mutation that changes the interaction between PI3K  and the membrane
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
Perturbation of the mutated EGFR interactome identifies vulnerabilities and resistance mechanisms
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
Integrin/Fak/Src-mediated regulation of cell survival and anoikis in human intestinal epithelial crypt cells: selective engagement and roles of PI3-K isoform complexes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
Gain of interaction with IRS1 by p110α-helical domain mutants is crucial for their oncogenic functions
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
Mal connects TLR2 to PI3Kinase activation and phagocyte polarization
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
C-mip interacts with the p85 subunit of PI3 kinase and exerts a dual effect on ERK signaling via the recruitment of Dip1 and DAP kinase
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
Hijacking Dlg1 for oncogenic phosphatidylinositol 3-kinase activation in human epithelial cells is a conserved mechanism of human adenovirus E4-ORF1 proteins
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
Phospho-tyrosine dependent protein-protein interaction network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
A human interactome in three quantitative dimensions organized by stoichiometries and abundances
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
Ligand-independent HER2/HER3/PI3K complex is disrupted by trastuzumab and is effectively inhibited by the PI3K inhibitor GDC-0941
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
retrieved
9 May 2019
stated in
The p85 regulatory subunit of phosphoinositide 3-kinase down-regulates IRS-1 signaling via the formation of a sequestration complex
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P42336
determination method
IPI
cell component
biological process
Gene Atlas image
PBB GE PIK3CA 204369 at fs.png
732 × 530; 11 KB
0 references

Identifiers

MeSH descriptor ID
C484760
subject named as
PIK3CA protein, human
0 references
PDB structure ID
 
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