Protein kinase C alpha (Q7119501)

Protein kinase-like domain superfamily

1 reference

protein kinase C, alpha/beta/gamma types

1 reference

Protein kinase C-like, phorbol ester/diacylglycerol-binding domain, protein family

1 reference

Protein kinase, C-terminal domain, protein family

1 reference

C2 domain, protein family

1 reference

Diacylglycerol/phorbol-ester binding domain, protein family

1 reference

AGC-kinase, C-terminal domain, protein family

1 reference

Classical Protein Kinase C alpha, catalytic domain, protein family

1 reference

Protein kinase domain, protein family

1 reference

Protein kinase, ATP binding site, protein family

1 reference

Serine/threonine-protein kinase, active site, protein family

1 reference

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

13 November 2019

1 reference

13 November 2019

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

protein kinase C activity

4 references

8 April 2019

Multiple, distinct forms of bovine and human protein kinase C suggest diversity in cellular signaling pathways

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

protein serine/threonine kinase activity

7 references

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

3 January 2017

Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

3 January 2017

Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

3 January 2017

Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

3 January 2017

Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

8 references

8 April 2019

The A-kinase anchoring protein 15 regulates feedback inhibition of the epithelial Na+ channel

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Centaurin-alpha(1) associates with and is phosphorylated by isoforms of protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Protein kinase C alpha-mediated phosphorylation of PIM-1L promotes the survival and proliferation of acute myeloid leukemia cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Essential function of TORC2 in PKC and Akt turn motif phosphorylation, maturation and signalling

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

PKC alpha regulates Sendai virus-mediated interferon induction through HDAC6 and β-catenin

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

The INAD scaffold is a dynamic, redox-regulated modulator of signaling in the Drosophila eye

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Direct binding of syndecan-4 cytoplasmic domain to the catalytic domain of protein kinase C alpha (PKC alpha) increases focal adhesion localization of PKC alpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

histone kinase activity (H3-T6 specific)

1 reference

8 April 2019

Phosphorylation of histone H3T6 by PKCbeta(I) controls demethylation at histone H3K4

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

2 references

calcium-dependent protein kinase C activity

1 reference

1 January 2018

http://www.ebi.ac.uk/QuickGO/annotations?protein=P17252&geneProductId=UniProtKB:P17252

protein serine/threonine kinase activity

8 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Identification of the major phosphorylation sites for protein kinase C in kit/stem cell factor receptor in vitro and in intact cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Modulation of Kit/stem cell factor receptor-induced signaling by protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Protein kinase C alpha-dependent phosphorylation of the mRNA-stabilizing factor HuR: implications for posttranscriptional regulation of cyclooxygenase-2

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

3 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Calcitonin promotes outgrowth of trophoblast cells on endometrial epithelial cells: involvement of calcium mobilization and protein kinase C activation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

mitochondrial membranes

1 reference

8 April 2019

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

5 references

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

The major chemical-detoxifying system of UDP-glucuronosyltransferases requires regulated phosphorylation supported by protein kinase C

endoplasmic reticulum

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

perinuclear region of cytoplasm

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

alphav-beta3 integrin-PKCalpha complex

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

Large-scale proteomics and phosphoproteomics of urinary exosomes

extracellular exosome

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

negative regulation of adenylate cyclase activity

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

response to interleukin-1

1 reference

8 April 2019

Activation of ROS/NF-kappaB and Ca2+/CaM kinase II are necessary for VCAM-1 induction in IL-1beta-treated human tracheal smooth muscle cells

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of endothelial cell proliferation

1 reference

8 April 2019

Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

regulation of mRNA stability

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

regulation of insulin secretion

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of cell migration

1 reference

8 April 2019

Unraveling the role of KIAA1199, a novel endoplasmic reticulum protein, in cancer cell migration

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

negative regulation of glial cell apoptotic process

1 reference

8 April 2019

Induction of p53-dependent, insulin-like growth factor-binding protein-3-mediated apoptosis in glioblastoma multiforme cells by a protein kinase Calpha antisense oligonucleotide

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of macrophage differentiation

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of mitotic cell cycle

1 reference

8 April 2019

Involvement of p21(Waf1/Cip1) in protein kinase C alpha-induced cell cycle progression

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

activation of adenylate cyclase activity

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

positive regulation of angiogenesis

1 reference

8 April 2019

Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of cardiac muscle hypertrophy

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of endothelial cell migration

1 reference

8 April 2019

Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of lipopolysaccharide-mediated signaling pathway

1 reference

8 April 2019

Protein kinase C-alpha modulates lipopolysaccharide-induced functions in a murine macrophage cell line

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

mitotic nuclear membrane disassembly

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

Plakophilin 2: a critical scaffold for PKC alpha that regulates intercellular junction assembly

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

peptidyl-serine phosphorylation

1 reference

3 January 2017

http://www.ebi.ac.uk/QuickGO/GAnnotation?protein=P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of blood vessel endothelial cell migration

1 reference

8 April 2019

A phosphoinositide 3-kinase/phospholipase Cgamma1 pathway regulates fibroblast growth factor-induced capillary tube formation

Developmental FunctionaL Annotation at Tufts

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of ERK1 and ERK2 cascade

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

apoptotic signaling pathway

1 reference

8 April 2019

Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of dense core granule biogenesis

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

regulation of platelet aggregation

1 reference

8 April 2019

Direct Demonstration of Involvement of Protein Kinase Cα in the Ca2+-induced Platelet Aggregation

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of cell adhesion

1 reference

8 April 2019

Inhibition of protein kinase Calpha prevents endothelial cell migration and vascular tube formation in vitro and myocardial neovascularization in vivo

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

ERBB2 signaling pathway

1 reference

8 April 2019

peptidyl-threonine phosphorylation

1 reference

8 April 2019

Microtubule affinity-regulating kinase 2 functions downstream of the PAR-3/PAR-6/atypical PKC complex in regulating hippocampal neuronal polarity

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of bone resorption

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

positive regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathway

1 reference

8 April 2019

http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:P17252

physically interacts with

ingenol mebutate

1 reference

7443

17 August 2016

1 reference

8142

17 August 2016

1 reference

5693

17 August 2016

1 reference

5263

17 August 2016

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL565612

1 reference

Open Targets Platform

retrieved

14 August 2023

https://platform.opentargets.org/drug/CHEMBL494089

has part(s)

AGC-kinase, C-terminal

1 reference

protein kinase, ATP binding site

1 reference

protein kinase domain

1 reference

protein kinase, C-terminal

1 reference

protein kinase C-like, phorbol ester/diacylglycerol-binding domain

1 reference

serine/threonine-protein kinase, active site

1 reference

diacylglycerol/phorbol-ester binding

1 reference

C2 domain

1 reference

Classical Protein Kinase C alpha, catalytic domain

1 reference

D08.811.913.696.620.682.700.725.100

Identifiers

MeSH descriptor ID

D051571

subject named as

Protein Kinase C-alpha

0 references

MeSH tree code

0 references

D12.776.476.563.725.100

0 references

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

30 May 2020

1 reference

13 November 2019

1 reference

1 reference

1 reference

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016

1 reference

9 August 2016