Protein kinase C delta (Q7120338)

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mammalian protein found in Homo sapiens
  • tyrosine-protein kinase PRKCD
  • protein kinase C delta type
  • 2.7.10.2
  • PRKCD
  • nPKC-delta
  • protein kinase C delta VIII
edit
Language Label Description Also known as
English
Protein kinase C delta
mammalian protein found in Homo sapiens
  • tyrosine-protein kinase PRKCD
  • protein kinase C delta type
  • 2.7.10.2
  • PRKCD
  • nPKC-delta
  • protein kinase C delta VIII

Statements

molecular function
protein binding
determination method
IPI
17 references
retrieved
8 April 2019
stated in
Protein kinase Cdelta is responsible for constitutive and DNA damage-induced phosphorylation of Rad9
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
PKCdelta regulates collagen-induced platelet aggregation through inhibition of VASP-mediated filopodia formation
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
DIK, a novel protein kinase that interacts with protein kinase Cdelta. Cloning, characterization, and gene analysis
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Using an in situ proximity ligation assay to systematically profile endogenous protein-protein interactions in a pathway network
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Direct interaction in T-cells between thetaPKC and the tyrosine kinase p59fyn
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
PKCδ stabilizes TAp63 to promote cell apoptosis
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
IL-32θ negatively regulates IL-1β production through its interaction with PKCδ and the inhibition of PU.1 phosphorylation
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Protein kinase Cdelta regulates p67phox phosphorylation in human monocytes
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Physical and functional interaction between protein kinase C delta and Fyn tyrosine kinase in human platelets
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Regulated binding of the protein kinase C substrate GAP-43 to the V0/C2 region of protein kinase C-delta
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Interleukin (IL)-32β-mediated CCAAT/enhancer-binding protein α (C/EBPα) phosphorylation by protein kinase Cδ (PKCδ) abrogates the inhibitory effect of C/EBPα on IL-10 production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Protein kinase C-δ negatively regulates T cell receptor-induced NF-κB activation by inhibiting the assembly of CARMA1 signalosome
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Interleukin-32δ interacts with IL-32β and inhibits IL-32β-mediated IL-10 production
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
retrieved
8 April 2019
stated in
Identification of a novel protein kinase Cδ-Smac complex that dissociates during paclitaxel-induced cell death
GOA
curator
IntAct protein interaction database
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IPI
protein serine/threonine kinase activity
determination method
IEA
IDA
EXP
TAS
8 references
retrieved
31 October 2017
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
TAS
retrieved
31 October 2017
stated in
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IEA
retrieved
31 October 2017
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IEA
retrieved
31 October 2017
stated in
Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
31 October 2017
stated in
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
31 October 2017
stated in
PKCdelta-dependent functional switch of rpS3 between translation and DNA repair
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
31 October 2017
stated in
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
EXP
retrieved
31 October 2017
stated in
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
EXP
protein serine/threonine kinase activity
determination method
EXP
IBA
IDA
IEA
TAS
9 references
retrieved
1 January 2018
stated in
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
TAS
retrieved
1 January 2018
stated in
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IEA
retrieved
1 January 2018
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IEA
retrieved
1 January 2018
stated in
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
1 January 2018
stated in
Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
1 January 2018
stated in
PKCdelta-dependent functional switch of rpS3 between translation and DNA repair
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
1 January 2018
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
IBA
retrieved
1 January 2018
stated in
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
EXP
retrieved
1 January 2018
stated in
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?protein=Q05655&geneProductId=UniProtKB:Q05655
determination method
EXP
protein serine/threonine kinase activity
determination method
EXP
IBA
IDA
IEA
8 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
InterPro
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IEA
retrieved
8 April 2019
stated in
Regulation of phospholipid scramblase activity during apoptosis and cell activation by protein kinase Cdelta
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
8 April 2019
stated in
PKCdelta-dependent functional switch of rpS3 between translation and DNA repair
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
8 April 2019
stated in
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
8 April 2019
stated in
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
GOA
curator
GO Central
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IBA
retrieved
8 April 2019
stated in
Sphingosine kinase mediates vascular endothelial growth factor-induced activation of ras and mitogen-activated protein kinases
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
EXP
retrieved
8 April 2019
stated in
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
GOA
curator
Reactome
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
EXP
cell component
nucleus
determination method
IDA
IEA
6 references
retrieved
8 April 2019
stated in
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IEA
retrieved
8 April 2019
stated in
GOA
curator
Ensembl genome database project
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IEA
retrieved
8 April 2019
stated in
Roles of tyrosine phosphorylation and cleavage of protein kinase Cdelta in its protective effect against tumor necrosis factor-related apoptosis inducing ligand-induced apoptosis
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
8 April 2019
stated in
Posttranslational modification of the AU-rich element binding protein HuR by protein kinase Cdelta elicits angiotensin II-induced stabilization and nuclear export of cyclooxygenase 2 mRNA
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
8 April 2019
stated in
Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IDA
retrieved
8 April 2019
stated in
Protein kinase C delta activates topoisomerase IIalpha to induce apoptotic cell death in response to DNA damage
GOA
curator
UniProt
UniProt protein ID
Q05655
reference URL
http://www.ebi.ac.uk/QuickGO/annotations?geneProductId=UniProtKB:Q05655
determination method
IDA
biological process

Identifiers

 
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