Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study) (Q71482533)

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scientific article published on 01 December 1995

Language	Label	Description	Also known as
English	Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study)	scientific article published on 01 December 1995

Statements

scholarly article

1 reference

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18 October 2019

Treatment of symptomatic diabetic peripheral neuropathy with the anti-oxidant alpha-lipoic acid. A 3-week multicentre randomized controlled trial (ALADIN Study) (English)

1 reference

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18 October 2019

multicenter clinical trial

1 reference

based on heuristic

inferred from title

randomized controlled trial

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based on heuristic

inferred from title

peripheral neuropathy

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based on heuristic

inferred from title

author name string

D Ziegler

1

1 reference

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18 October 2019

M Hanefeld

2

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18 October 2019

K J Ruhnau

3

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18 October 2019

H P Meissner

4

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18 October 2019

M Lobisch

5

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18 October 2019

K Schütte

6

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18 October 2019

F A Gries

7

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18 October 2019

publication date

1 December 1995

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18 October 2019

1 reference

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18 October 2019

38

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18 October 2019

1425-1433

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18 October 2019

12

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18 October 2019

https://scigraph.springernature.com/pub.10.1007/bf00400603

0 references

Effects of desipramine, amitriptyline, and fluoxetine on pain in diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

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Intention-to-treat analysis and the goals of clinical trials

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

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Aldose reductase inhibitors in the treatment of diabetic neuropathy. A review of the rationale and clinical evidence

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

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Oxygen free radical effects in sciatic nerve in experimental diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

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Acetyl-L-carnitine for symptomatic diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

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Effect of alpha-tocopherol deficiency on indices of oxidative stress in normal and diabetic peripheral nerve

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

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A Controlled Trial of Sorbinil, an Aldose Reductase Inhibitor, in Chronic Painful Diabetic Neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

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Free radical activity and hemostatic factors in NIDDM patients with and without microalbuminuria.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Weakened cellular scavenging activity against oxidative stress in diabetes mellitus: regulation of glutathione synthesis and efflux

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Topical capsaicin in the treatment of painful diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-oxidant treatment prevents the development of peripheral nerve dysfunction in streptozotocin-diabetic rats.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The natural history of somatosensory and autonomic nerve dysfunction in relation to glycaemic control during the first 5 years after diagnosis of type 1 (insulin-dependent) diabetes mellitus

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effects of thioctic acid on motor nerve terminals in acrylamide-poisoned rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Oxidative damage in neurodegenerative disease

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The relationship of vascular changes to metabolic factors in diabetes mellitus and their role in the development of peripheral nerve complications

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Withdrawal of the aldose reductase inhibitor tolrestat in patients with diabetic neuropathy: effect on nerve function. The Tolrestat Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Antidepressants in the treatment of diabetic neuropathy symptoms. Pharmacodynamic, -kinetic, and -genetic aspects.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of anti-oxidant treatment on sciatic nerve dysfunction in streptozotocin-diabetic rats; comparison with essential fatty acids

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The use of gamma linolenic acid in the prevention and treatment of diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

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Differential effects of near-normoglycaemia for 4 years on somatic nerve dysfunction and heart rate variation in type 1 diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

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Aminoguanidine effects on nerve blood flow, vascular permeability, electrophysiology, and oxygen free radicals

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential therapeutic approaches to the treatment or prevention of diabetic neuropathy: evidence from experimental studies

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Role of oxidative stress in development of complications in diabetes

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Treatment of painful diabetic neuropathy with topical capsaicin. A multicenter, double-blind, vehicle-controlled study. The Capsaicin Study Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Efficacy of thioctic acid in the therapy of peripheral diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Mexiletine in the treatment of diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Potential use of glutathione for the prevention and treatment of diabetic neuropathy in the streptozotocin-induced diabetic rat

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Aldose reductase inhibition improves nerve conduction velocity in diabetic patients

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

A multicentre study of the prevalence of diabetic peripheral neuropathy in the United Kingdom hospital clinic population

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Growth factors and diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Thioctic acid induces dose-dependent sprouting of neurites in cultured rat neuroblastoma cells

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of lipoic acid in hexacarbon-induced neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

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Thioctic Acid and Dihydrolipoic Acid are Novel Antioxidants Which Interact With Reactive Oxygen Species

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

[Drug treatment of diabetic polyneuropathy with alpha-lipoic acid or vitamin B preparations. A clinical and neurophysiologic study]

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Lipoic acid improves nerve blood flow, reduces oxidative stress, and improves distal nerve conduction in experimental diabetic neuropathy.

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Free radicals, antioxidants, and human disease: curiosity, cause, or consequence?

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Graphic representation of pain

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Impaired vasoreactivity to nitric oxide in experimental diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Relative mortality from overdose of antidepressants

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Effects of Pancreatic Transplantation on Diabetic Neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

The effect of intensive diabetes therapy on the development and progression of neuropathy. The Diabetes Control and Complications Trial Research Group

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Anti-oxidant and pro-oxidant effects on nerve conduction velocity, endoneurial blood flow and oxygen tension in non-diabetic and streptozotocin-diabetic rats

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

One-year treatment with the aldose reductase inhibitor, ponalrestat, in diabetic neuropathy

1 reference

https://pubmed.ncbi.nlm.nih.gov/8786016

12 December 2020

based on heuristic

inferred from PubMed ID database lookup

Identifiers

10.1007/BF00400603

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8786016%20AND%20SRC:MED&resulttype=core&format=json

18 October 2019

1 reference

Europe PubMed Central

https://www.ebi.ac.uk/europepmc/webservices/rest/search?query=EXT_ID:8786016%20AND%20SRC:MED&resulttype=core&format=json

18 October 2019

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